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Geletneky, K., et al (2017) Oncolytic H-1 parvovirus shows safety and signs of immunogenic activity in a first phase I/IIa glioblastoma trial. Molecular Therapy. [PubMedID: 28967558]
Hock, MB. et al. (2015) Immunogenicity of Antibody Drug Conjugates: Bioanalytical Methods and Monitoring Strategy fo a Novel Therapeutic Modality. The AAPS Journal. 17(1): 35-43. [PubMedID: 25380723]
Hofmann, M. et al. (2017) Analysis of the Novel Recombinant Factor VIII-SingleChain Protein Predicts A Lower Immunogenic Potential as Compared to Fulllength Recombinant FVIII. Special Issue: Abstracts of the XXVI Congress of the International Society on Thrombosis and Haemostasis, July 3-13, 2017. Abstract PB 1121, p. 774.
Hui, D., et al (2015) AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes. Mol Ther Methods Clin Dev. (2) 15029; [PubMedID: PMC4588448]
Lamberth, K. et al (2017) Post hoc assessment of the immunogencity of bioengineered factor VIIa demonstrates the use of preclinical tools. Science Translational Medicine 9(372). [PubMedID: 28077675]
Leone, D. A. et al (2017) Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes. Journal of Immunology 199(2):531-546. [PubMedID: 28607115]
Marakovsky, E. et al (2016) Profiling and Comparing the Immunogenicity of a Novel Single-Chain FVIII Molecule (rVIII-SingleChain) for the Treatment of Hemophilia A. Blood 128(22): 4960.
Ventura et al (2012) HLA-DR and HLA-DP Restricted Epitopes from Human Cytomegalovirus Glycoprotein B Recognized by CD4+ T-Cell Clones from Chronically Infected Individuals. Journal of Clinical Immunology[PubMedID: 22797815]
Xue, L.1, Hickling, T.1, Song, R.2, Nowak, J.3, & Rup, B.1 (2015) Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human IL-21 receptor‐blocking therapeutic antibody. Clinical Experimental Immunology; (Accepted Article); 24 September 2015. [PubMedID: 26400440]
1 Pharmacokinetics, Dynamics,& Metabolism -NBE, Pfizer, Inc.
2 Drug Safety R&D, Pfizer, Inc.
3 Clinical Pharmacology, Pfizer, Inc.
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Ahmed, SS. et al. (2015) Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2. Science Translational Medicine. 7(294). [PubMedID: 26136476]
Bell, MJ. et al. (2009) The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in length. Mol Immunol. 46: 1911-1917[PubMedID: 19157553]
Berinstein, N.L. et al (2012) First-in-man application of a novel therapeutic cancer vaccine formulation with the capacity to induce multi-functional T cell responses in ovarian, breast and prostate cancer patients. Journal of Translational Medicine. 10(1):156. [PubMedID: 22862954]
Blancou, P. et al. (2007). Immunization of HLA Class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients. J. Immunol. 178: 7458-7466. [PubMedID: 17513797]
Burlingham, W. et al (2013). Epitope analysis of the collagen type V-specific T cell response in lung transplantation reveals an HLA-DRB1*15 bias in both recipient and donor. PLoS One 8(11). [PubMedID: 24265781]
Burrows, J.M. et al. (2007). The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV. Eur. J. Immunol. 37: 946-953. [PubMedID: 17357107].
Bui et al (2010) Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model. Vaccine 28:6028 [PubMedID: 20619375]
Dang et al (2011) Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8. Journal of Immunology 186:6063 [PubMedID: 21471440]
Freed et al (2011) Association of the HLA-DRB1 epitope LA(67, 74) with rheumatoid arthritis and citrullinated vimentin binding. Arthritis Rheumatism 63:3733 [PubMedID: 22094856]
Gerstner, C. et al. (2016). Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted alpha-Enolase T Cell Epitope in Rheumatoid Arthritis. Frontiers in Immunology. (doi: 10.3389/fimmu.2016.00494/full)
Gomez-Tourino, I. et al. (2015). Characterization of the autoimmune response against the nerve tissue S100β in patients with type 1 diabetes. Clinical and Experimental Immunology. 180(2): 207-17. [PubMedID: 25516468]
Harrop, R. et al. (2008). Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses. Cancer Immunol. Immunother. 57: 977-86. [PubMedID: 18060404] Read Case Study
Keller et al (2013). Epitope analysis of the collagen type V-specific T cell response in lung transplantation reveals an HLA-DRB1*15 bias in both recipient and donor. PLoS One 8(11): e79601.
Lepone et al (2010) Monofunctional and polyfunctional CD8+ T cell responses to human herpesvirus 8 lytic and latency proteins. Clinical and Vaccine Immunology 17:1507 [PubMedID: 20719985] Read Case Study
Liu et al. (2014) Preliminary exploration of HLA-A*1101-restricted human cytomegalovirus glycoprotein B-specific CD8+ T cells in allogeneic stem-cell transplant recipients. Virus Research. 188:38, pp.38-44.[PubmedID: 24704672]
MacNamara, A et al (2010). HLA Class I Binding of HBZ Determines Outcome in HTLV-1 Infection. PLoS Pathogens 6: e1001117 [PubMedID: 20886101]
Muixi, L. et al (2008). Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands. J Immunol. 181: 795-807 [PubMedID: 18566446] Read Case Study
Ofran et al (2010) Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes. Clinical Cancer Research 16:1642 [PubMedID: 20160060]
Oliveira, ALA. et al. (2009). High Frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 (HTLV-2) infection. J Immunol. 183: 2597-2965 [PubMedID: 19657093]Read Case Study
Pandey et al (2013). Polymorphisms in the F8 Gene and MHC-II Variants as Risk Factors for the Development of Inhibitory Anti- Factor VIII Antibodies during the Treatment of Hemophilia A: A Computational Assessment. PLoS Computational Biology 9(5): e1003066. [PubMed ID: 23696725]
Pieper et al (2012) α-enolase specific T cells in rheumatoid arthritis – a MHC class II tetramer approach Annals of the Rheumatic Diseases 71:A33
Ramaswami, B. et al. (2009) HLA-A01, -A03 and -A024 binding nanomeric epitopes in polyomavirus BK large T-antigen. Human Immunology. doi: 10.1016/j.humimm.2009.05.003 [PubMedID: 19446588]
Ramesh, M. et al. (2016) Peanut T-cell epitope discovery: Ara h 1. The Journal of Allergy and Clinical Immunology. 137(6): 1764-1771. [PubMedID: 26953158]
Robey et al (2011) Ex-vivo recognition of late-lytic CD8 epitopes specific for Kaposi’s sarcoma-associated herpesvirus (KSHV) by HIV/KSHV-coinfected individuals.. Viral Immunology 24:211 [PubmedID: 21668362]
Scotto et al (2012) Zinc transporter (ZnT)8186–194 is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients Diabetologica [PubMedID: 22526607]
Steeter, HB. et al. (2015) Preclinical development and first-in-human study of ATX-MS-1467 for immunotherapy of MS. Neurology, Neuroimmunology & Neuroinflammation. 2(3). [PubMedID: 25798453]
Steinitz K. et al (2012) CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice. Blood (in press)[PubmedID: 22394599] Read Case Study
van der Heiden, P. et al. (2009). Identification of Varicella Zoster Virus specific CD8 T cells in patients after T cell depleted allogeneic stem cell transplantation. J. Virol. 83: 7361-7364. [PubMedID: 19386715] Read Case Study
Weiskopf, D. et al. (2009). Oxidative stress can alter the antigenicity of immunodominant peptides. J. Leukoc. Biol. 87: epub ahead of print. [PubMedID: 19801502] Read Case Study
Westrop, S. et al. (2009). Novel approach to recognition of predicted HIV-1 Gag B*3501-restricted CD8 T-cell epitopes by B*3501+ patients: Confirmation by quantitative ELISPOT analyses and characterisation using multimers. J Immunol. Methods. 341: 76-85 [PubMedID: 19056394] Read Case Study
Cerullo, V et al. (2010) Oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor induces antitumoral immunity in cancer patients. Cancer Research 70(11):4297-309 [PubMedID: 20484030]Read Case Study
Mahlangu, J. et al (2016) TRUST trial: BAY 86-6150 use in haemophilia with inhibitors and assessment for immunogenicity. Haemophilia. 22(6): 873-879. [PubMedID: 27501279]
O’Brien et al (2012) A humanised murine monoclonal antibody protects mice from Venezuelan equine encephalitis virus, Everglades virus and Mucambo virus when administered up to 48h after airborne challenge. Virology 426:100 [PubMedID: 22341308] Read Case Study
Arnaboldi et al (2013) An outer surface protein C (OspC) peptide derived from Borrelia burgdorferi sensu strico as a target for the serodiagnosis of early Lyme disease. Clin. Vaccine Immunol. 20:474-481 [PubMedID: 23365204] Read Case Study
Kim et al (2012) Development of an in vitro antigen-detection test as an alternative method to the in vivo plaque reduction neutralization test for the quality control of Japanese encephalitis virus vaccine Microbiology and Immunology [PubMedID: 22486472]
O’Brien et al (2014) Vaccination with recombinant adenoviruses expressing Ebola virus glycoprotein elicits protection in the interferon alpha/beta receptor knock-out mouse. Virology. 452:324-333 [PubMedID: 24461913]
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Hoffmann, S. et al (2008) HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis. American Journal of Human Genetics. 83(2): 219-27. [PubMedID: 18656179]
Link, J. et al (2014) Human leukocyte antigen genes and interferon beta preparations influence risk of developing neutralizing anti-drug antibodies in multiple sclerosis. PLoS One. 9(3):e90479. [PubMedID: 24608124]
Mahlangu, J.N. (2015) Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity. Journal of Thrombosis and Haemostasis. 13(11): 1989-98 [PubMedID: 26362483]
Steven, J. et al (2017) In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development. Frontiers in Immunology. [PubMedID: 29109729]