Immunotoxicology testing requires detailed investigation of an immune response. It is important to be sure that the assays you choose give you the information you need to solve the question of why a new drug has an adverse effect on the immune system.
ProImmune’s advanced technologies in evaluating cellular and humoral immune responses can help you understand the immunotoxicology of your compound, including:
We can perform many standard measurements for you, and retain the ability to design studies that answer more complex questions. These include studies of alteration of the function of dendritic cells and perturbation of antigen specific T and B cell responses.
We manage whole studies for our customers, from donor recruitment to data reporting.
It may be crucial to test your drug’s effect using cell samples from a particular subset of the population, for example those with known allergies, or those aged over 50.
ProImmune has the capability to carry out in vitro studies on cellular and serum samples derived from donors from two sources:
We have developed expertise in a range of assays, all of which can be adapted to look at aspects of immunotoxicology. We can perform:
With our specialist experience in human immunology as well as our ability to source samples from large donors cohorts, we can address questions that are beyond the capabilities that you may have in-house or with your generalist CRO. The data obtained from in vitro human cell experiments we perform can add depth to the interpretation of results obtained in model systems.
To discuss the specialist requirements for your study please contact our customer service team today.