ProM1 MHC Class I Monomers, biotin labeled

enabling specialist assays for defined

MHC Class I peptide target interactions

Figure: ProM1 Monomer

Best in Class MHC Class I Monomers

ProM1 Class I MHC Monomers are provided already biotin labeled and can be readily adapted to implement specialist solid or solution phase immunoassays or for measuring interactions of predefined MHC Class I-peptide complexes with ligands such as monoclonal antibodies, recombinant T cell receptors, or other binding scaffolds, e.g. for use in screening of novel antigen-specific CAR T cell antigen receptors.

ProM1 MHC Monomers are made by ProImmune’s experienced team who have been providing superior MHC reagents for more than 18 years now, including our world-leading Pro5® MHC Class I Pentamers.

ProImmune provides ProM1 Class I MHC Monomers  with responsive, expert technical support and customer service. Contrary to ordering class I monomers from in-house or non-commercial facilities, customers do not need to apply and wait for reagents or supply any peptide. ProM1 Class I MHC Monomers are delivered quickly with stringent quality control and low batch-to-batch variability. As such, ProM1 Class I MHC Monomers complement ProImmune’s existing Pro5® Class I Pentamer technology for detecting antigen-specific CD8+ T cells.

Available Quantities

35ug, 100ug; please contact us for larger quantities

Catalog ProM1™ Class I MHC Monomers

Catalog ProM1™ Monomers are available within 1-2 weeks of placing an order.

DISEASE AREAALLELEPEPTIDE CODEPEPTIDE SEQUENCEEPITOPE ORIGIN
CancerA*02:0182ELAGIGILTVMelanA / MART 26-35
CancerA*02:0149SLLMWITQCNY-ESO-1 157-165 (9C)
CMVA*02:018NLVPMVATVHCMV pp65 495-504

Custom ProM1 Class I MHC Monomers

Custom ProM1 Monomers for your allele/peptide of interest are available within approximately 6-7 weeks from ordering. Peptide sequences are subject to prior evaluation by ProImmune for binding. Once a peptide sequence is accepted for custom synthesis we will synthesize both the peptide and MHC monomer reagent.

Available Alleles

HLA-A*01:01, A*02:01, A*03:01, A*11:01, A*24:02

HLA-B*07:02, B*08:01, B*35:01

HLA-E*01:01

H-2 Kb, Kd, Db, Ld

If your allele is not on the list above, please enquire.

Features of ProM1 Class I MHC Monomers

  • From the most experienced commercial providers of MHC multimers
  • Proven technology for detecting antigen-specific T cells
  • Broadest range of catalog items available
  • Flexible labelling options
  • Long-term storage
  • Industry leading customer service from immunologists who understand your work