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Custom Ankyrons
Custom Ankyrons®
Can’t find your target on our Ankyron Catalog? Request custom generation at no additional cost.
Custom Reagents made Simple and Accessible
Ankyron generation uses a scalable selection process allowing multiple proteins to be screened in parallel in a rapid and cost-effective manner. This sits in contrast to monoclonal antibody generation, which requires immunization and cloning approaches, resulting in a high cost, inefficient development process. We aim to improve the availability and accessibility of reagents across the research community with no additional associated costs for new targets as set out below.
Our Custom Process
Step 1. Target Request: Fill in an Ankyron Target Request form for your protein(s) of interest and submit the completed form to enquiries@proimmune.com. This takes approximately 15 minutes to complete and asks for details of your current research, protein target and intended applications. Each target is reviewed and subject to approval through our internal assessment process. We welcome requests for Ankyron generation across a broad range of research areas, and the majority of targets submitted are currently approved.
Step 2. Ankyron Generation: If your request is approved, we will express your target(s) of interest in our AnkyronX platform, with optimized targets designed and produced by our team. Resulting proteins will be screened against our Ankyron teralibrary using ribosome display, with binding of resulting clones confirmed by immunoassay. All reagents are monoclonal and recombinant by default.
Step 3. Catalog Addition: Ankyrons that we generate as confirmed binders to your target(s) of interest will be added to our catalog and you will be notified that they have become available. You can then purchase these Ankyrons for testing at our standard catalog prices (no extra charge is levied for their generation).
Step 4. Your Research: Test multiple Ankyron clones in the application of your choice to select your preferred clone going forward. In particular cases and upon request, we may be able to pre-qualify your clones of interest internally at ProImmune before they are ordered from our catalog. Flexible labeling options and scalable expression are available at all times to accommodate research requirements going forward.
Ankyrons Create Research Opportunities
 Remove research limits – Reduce constraints on the number of study proteins |  Build target panels – Develop panels of Ankyrons to study an array of target proteins |  Additional applications – Find reagents that function in your required application |
 Protein-level quantification – Applied as an alternative or supplement to RNA-seq |  Rapid target access – Quickly access reagents for novel, neglected and rapidly evolving targets |  Remove tagging requirements – Investigate targets without the need for protein tagging strategies |