REVEAL® & ProVE® MHC-Peptide Binding Assay Publications

Huang, Y., et al. (2026). “Preclinical Assessment of HLA-A*02:01-Restricted PSMA and STEAP1 Epitopes for Peptide-Based Immunotherapy in Prostate Cancer.” Drug Design, Development and Therapy, 20. https://doi.org/10.2147/DDDT.S576346

Balogh, G.M., et al. (2025). ” C > U mutations generate immunogenic peptides in SARS-CoV-2.” Nat Commun 16, 10156 (2025). https://doi.org/10.1038/s41467-025-65251-8

Niizuma K, (2025). “Development of iPSC-derived T cells targeting EGFR neoantigens in non-small cell lung cancer.” Molecular Therapy Methods & Clinical Development, 2025; 33. https://doi.org/10.1016/j.omtm.2025.101517

Eggenhuizen, P.J., et al. (2024). “Smith-specific regulatory T cells halt the progression of lupus nephritis.” Nat Commun 15, 899 (2024). https://doi.org/10.1038/s41467-024-45056-x

Voskamp AL, et al. (2024). “Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy. Allergy.” 2024;79:485-498. https://doi.org/10.1111/all.15966

Curran, A.M., et al. (2023). “Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis.” Nat Commun 14, 1061 (2023). https://doi.org/10.1038/s41467-023-36620-y

Inaba H, et al. (2023). “Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors.” Front. Immunol. 14:1165004. https://doi.org/10.3389/fimmu.2023.1165004

Kacen, A., et al. (2023). “Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors.” Nat Biotechnol 41, 239–251 (2023). https://doi.org/10.1038/s41587-022-01464-2

Nandre R., et al. (2022). “IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status.” Cancer Immunol Res 1 May 2022; 10 (5): 571–580. https://doi.org/10.1158/2326-6066.CIR-21-0457

Chyu KY, et al. (2022). “Immunization using ApoB-100 peptide-linked nanoparticles reduces atherosclerosis.” JCI Insight. 2022 Jun 8;7(11):e149741. https://doi.org/10.1172/jci.insight.149741

Ochoa R, et al. (2022) “Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol.” Front. Immunol. 13:862851. https://doi.org/10.3389/fimmu.2022.862851

Pletinckx K, et al. (2022). “Antigen-specific immunotherapy with apitopes suppresses generation of FVIII inhibitor antibodies in HLA-transgenic mice.” Blood Adv 2022; 6 (7): 2069–2080. https://doi.org/10.1172/jci.insight.149741

Sricharoensuk C, et al. (2022) “Unsupervised Mining of HLA-I Peptidomes Reveals New Binding Motifs and Potential False Positives in the Community Database.” Front. Immunol. 13:847756. https://doi.org/10.3389/fimmu.2022.847756

Kacen A, et al. (2022). “Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors.” Nat Biotechnol. 2023 Feb;41(2):239-251. https://doi.org/10.1038/s41587-022-01464-2

Hellesen A, et al. (2021). “21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison’s Disease Are Restricted by HLA-A2 and HLA-C7 Molecules.” Front. Immunol. https://doi.org/10.3389/fimmu.2021.742848

Rosenbaum P, et al. (2020). “The fully synthetic glycopeptide MAG-Tn3 therapeutic vaccine induces tumor-specific cytotoxic antibodies in breast cancer patients.” Cancer Immunol Immunother. 2020 May;69(5):703-716. https://doi.org/10.1007/s00262-020-02503-0

Milcent B, et al. (2019). “Presence of T cells directed against CD20-derived peptides in healthy individuals and lymphoma patients.” Cancer Immunol Immunother. 2019 Oct;68(10):1561-1572. https://doi.org/10.1007/s00262-019-02389-7

Jansson L., et al. (2018). “Immunotherapy With Apitopes Blocks the Immune Response to TSH Receptor in HLA-DR Transgenic Mice.” Endocrinology, Volume 159, Issue 9, September 2018, Pages 3446–3457. https://doi.org/10.1210/en.2018-00306

Paul C. Dimayuga, et al. (2017). “Identification of apoB‐100 Peptide‐Specific CD8+ T Cells in Atherosclerosis.” Journal of the American Heart Association. Volume 6, Number 7. https://doi.org/10.1161/JAHA.116.005318

Gerstner C, et al. (2016). “Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis.” Front. Immunol. 7:494. https://doi.org/10.3389/fimmu.2016.00494

Ramesh M, et al. (2015). “Peanut T-cell epitope discovery: Ara h 1.” Journal of Allergy and Clinical Immunology, 2016; 137, 1764-1771.e4. https://doi.org/10.1016/j.jaci.2015.12.1327

Gómez-Touriño I, et al. (2015). “Characterization of the autoimmune response against the nerve tissue S100β in patients with type 1 diabetes.” Clin Exp Immunol. 2015 May;180(2):207-17. https://doi.org/10.1111/cei.12572

Streeter HB, et al. (2015). “Preclinical development and first-in-human study of ATX-MS-1467 for immunotherapy of MS.” Neurol Neuroimmunol Neuroinflamm. 2015 Mar 12;2(3):e93. https://doi.org/10.1212/NXI.0000000000000093

Pandey GS, et al. (2013). “Polymorphisms in the F8 gene and MHC-II variants as risk factors for the development of inhibitory anti-factor VIII antibodies during the treatment of hemophilia a: a computational assessment.” PLoS Comput Biol. 2013;9(5):e1003066. https://doi.org/10.1371/journal.pcbi.1003066

Steinitz KN, et al. (2012). “CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice.” Blood. 2012 Apr 26;119(17):4073-82. https://doi.org/10.1182/blood-2011-08-374645

Weiskopf D., et al. (2010). “ Oxidative stress can alter the antigenicity of immunodominant peptides. Journal of Leukocyte Biology, Volume 87, Issue 1, Jan 2010, Pages 165–172. https://doi.org/10.1189/jlb.0209065

Westrop SJ, et al. (2009). “Novel approach to recognition of predicted HIV-1 Gag B3501-restricted CD8 T-cell epitopes by HLA-B3501(+) patients: confirmation by quantitative ELISpot analyses and characterisation using multimers.” J Immunol Methods. 2009 Feb 28;341(1-2):76-85. https://doi.org/10.1016/j.jim.2008.11.003

van der Heiden PL, et al. (2009). “Identification of varicella-zoster virus-specific CD8 T cells in patients after T-cell-depleted allogeneic stem cell transplantation.” J Virol. 2009 Jul;83(14):7361-4. https://doi.org/10.1128/jvi.02662-08

Ramaswami B, et al. (2009). “HLA-A01-, -A03-, and -A024-binding nanomeric epitopes in polyomavirus BK large T antigen.” Hum Immunol. 2009 Sep;70(9):722-8. https://doi.org/10.1016/j.humimm.2009.05.003

Oliveira AL, et al. (2009). “High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection.” J Immunol. 2009 Sep 1;183(5):2957-65. https://doi.org/10.4049/jimmunol.0900508