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MHC Class II Tetramer Publications
ProT2® MHC Class II Tetramer Selected Publications
Tetramer/Monomer Research Areas – Select a disease area to view publications
| Allergy | Aspergillus | Autoimmunity |
| Bordetella Pertussis | Cancer | CMV |
| COVID-19 / SARS-CoV-2 | EBV | Factor VIII |
| HBV | HCV | HIV |
| HPV | Influenza | Malaria |
| Multiple Sclerosis | Tetanus | Therapeutic Antibodies |
| Tuberculosis | Negative | Helicobacter pylori |
| LCMV | Listeria | Model Antigens |
| RSV | West Nile Virus | Other |
| Publication/Disease Area | Specificity |
|---|---|
Autoimmunity | |
| Gliwiński M, et al. (2020). “Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.” BMJ Open Diabetes Res Care. 2020 Feb;8(1):e000873. https://doi.org/10.1136/bmjdrc-2019-000873 | DRB1*04:01/GAGSLQPLALEGSLQKRG DRB1*04:01/IAFTSEHSHFSLK DRB1*04:01/GIVEQCCTSICSLYQ DRB1*04:01/NFIRMVISNPAAT |
Cytomegalovirus (CMV) | |
| McGee K, et al. (2025). “Valaciclovir therapy for secondary suppression of immune response to herpesviruses: An exploratory study.” PLOS Pathogens 21(12): e1013803. https://doi.org/10.1371/journal.ppat.1013803 | DRB1*15:01/MSIYVYALPLKMLNI |
| Esparcia-Pinedo L. et al. (2023). “T regulatory lymphocytes specific for SARS-CoV-2 display increased functional plasticity.” 10.1016/j.clim.2023.109806. https://doi.org/10.1016/j.clim.2023.109806 | DRB1*07:01/EPDVYYTSAFVFPTK |
| Naigeon M, et al. (2023). “Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC.” Sci Adv. 2023 Nov 10;9(45):eadh0708. https://doi.org/10.1126/sciadv.adh0708 | DRB1*07:01/EPDVYYTSAFVFPTK |
Factor VIII | |
| Ringler E, et al. (2023). “Complement protein C3a enhances adaptive immune responses towards FVIII products.” Haematologica. 2023 Jun 1;108(6):1579-1589. https://doi.org/10.3324/haematol.2022.281762 | DRB1*11:01/ENIQRFLPNPAGVQLEDPEF |
| Becker-Gotot J, et al. (2022). “Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs.” 10.1172/JCI159925. https://doi.org/10.1172/JCI159925 | DRB1*11:01/ENIQRFLPNPAGVQLEDPEF H-2IAb/TASSYFTNMFATWSPSKARL |
Lymphocytic choriomeningitis virus (LCMV) | |
| Zheng M, et al. (2026). “Immunodominance is a poor predictor of vaccine-induced T follicular helper cell quality.“eBioMedicine, 2026; 125. https://doi.org/10.1016/j.ebiom.2026.106185 | H2-IAb/DIYKGVYQFKSV |
| Yue S, et al. (2026). “Oncolytic virotherapy mobilizes tumor-resident, granzyme B-producing bystander CD4+ T cells to inhibit systemic microbial infection.” Molecular Therapy Oncology, 2026; 34. https://doi.org/10.1016/j.omton.2026.201187 | H2-IAb/DIYKGVYQFKSV |
Model Antigens | |
| Zhang, W., et al. (2024). “NitraTh epitope-based neoantigen vaccines for effective tumor immunotherapy.” Cancer Immunol Immunother 73, 245 (2024). https://doi.org/10.1007/s00262-024-03830-2 | H-2IAb/AKFVAAWTLKAA |
Negative | |
| Ammon, T., et al. (2025). “Citrullinated Autoantigen–Specific T and B Lymphocytes in Rheumatoid Arthritis: Focus on Follicular T Helper Cells and Expansion by Coculture.” ACR Open Rheumatology, 7: e11785. https://doi.org/10.1002/acr2.11785 | DRB1*04:01/PVSKMRMATPLLMQA |
| Wragg, K.M., et al. (2022). “Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory.” Nat Immunol 23, 768–780 (2022). https://doi.org/10.1038/s41590-022-01175-5 | DRB1*15:01/PVSKMRMATPLLMQA |
| Gliwiński M, et al. (2020). “Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.” BMJ Open Diabetes Res Care. 2020 Feb;8(1):e000873. https://doi.org/10.1136/bmjdrc-2019-000873 | DRB1*04:01/PVSKMRMATPLLMQA |
SARS-CoV-2 | |
| Liu, G., et al. (2025). “Long-persisting SARS-CoV-2 spike-specific CD4+ T cells associated with mild disease and increased cytotoxicity post COVID-19.” Nat Commun 16, 8743 (2025). https://doi.org/10.1038/s41467-025-63711-9 | DRB1*15:01/NLLLQYGSFCTQLNR DRB1*15:01/TDEMIAQYTSALLAG |
| Ming Z. et al. (2025). “Deconvoluting TCR-dependent and -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay.” Sci. Adv.11,eadv3491(2025). https://doi.org/10.1126/sciadv.adv3491 | DRB1*15:01/NLLLQYGSFCTQLNRAL |
| Dalit, L., et al. (2025). “Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity.” Nat Immunol 26, 1821–1835 (2025). https://doi.org/10.1038/s41590-025-02258-9 | DRB1*15:01/NLLLQYGSFCTQLNRAL |
| Esparcia-Pinedo L. et al. (2023). “T regulatory lymphocytes specific for SARS-CoV-2 display increased functional plasticity.” 10.1016/j.clim.2023.109806. https://doi.org/10.1016/j.clim.2023.109806 | DRB1*03:01/CTFEYVSQPFLMDLE |
| Wragg, K.M., et al. (2022). “Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory.” Nat Immunol 23, 768–780 (2022). https://doi.org/10.1038/s41590-022-01175-5 | DRB1*15:01/NLLLQYGSFCTQLNRAL DRB1*15:01/TRFQTLLALHRSYLT |