Transgenic mouse models have become an important tool with which to evaluate vaccinations with putative human antigens. HLA-A2 transgenic mice express modified class I MHC molecules combining the alpha-1 and alpha-2 domains of HLA-A*02:01 with the alpha-3 domain of H-2Kb.
In order to study the cytotoxic T cell immune response in such mice it has been suggested that chimeric A2Kb multimers can be used in order to detect accurately the relevant immune responses.
Choi EM, et al. (2002) [PubMedID:12213341]