Customer Case Studies Using Pro5® Pentamers

Our customers continually publish their research into a huge range of subjects.  Here we present selected publications, highlighting research using our Pro5® MHC Class I Pentamers in applications such as flow cytometry, separation of antigen-specific T cells with magnetic beads and intracellular cytokine staining.

A comprehensive list of customer publications is available here, and is frequently updated.



Immunovaccine Inc., Nova Scotia, Canada
Liposomes deliver an immune hit to cancer cells

Marcus Butler, Dana Farber Cancer Center, USA
Killer T Cells Trained for Long-lasting Anti-Cancer Effects

John Webb, British Columbia Cancer Agency, Canada
High-grade ovarian cancer: MHC Pentamers are used to investigate immunotherapy prospects.

Ingerid Abrahamsen, Oslo University Hospital, Oslo Norway
Allogeneic T cells may be targeted to B cell leukemia

Erlend Stronen, Radiumhospitalet, Norway 
Pentamers identify allo-restricted T cells in study to advance research into cancer immunotherapy

Maxim Pavlenko, Karolinska University Hospital, Sweden
Epitope discovery in prostate cancer: characterizing an immunodominant CTL epitope of PSA in mice.

James Wells, King’s College London, UK
New adjuvant drives unprecedented cytotoxic T cell response providing a potent vaccine development platform

Hiro Yagi, Hamamatsu University School of Medicine, Japan
Pro5® Pentamers integral in successful research into novel immunization strategy


Paul Moss, University of Birmingham, UK
Pro5® Pentamers are used to enrich CMV-specific T cells for transfusion into transplant patients



Stephanie Gras, Queensland Institute of Medical Research, Australia
Analysing allelic polymorphism in the T cell receptor and its impact on immune responses in an EBV setting

Judy Tellam, Queensland Institute of Medical Research, Australia 
Pro5® MHC Class I Pentamer combined with intracellular cytokine staining shows how protein translation affects the molecular dynamics of antigen presentation

Christopher Fox, University of Birmingham, UK
Researchers use Pro5® MHC Pentamers to identify an exciting new target for EBV treatment

Michael Uhlin, Karolinska Institute, Sweden
Pro5® Pentamers central in life-saving procedure for PTLD treatment

Suzanne Elliot, Queensland Institute of Medical Research, Australia
Pro5® MHC Class I Pentamers used to evaluate vaccine safety


Hepatitis (HBV and HCV)

Adam Gehring, Singapore Institute for Clinical Science, Singapore
Phenotypic analysis of HBV-specific T cells using Pro5® Pentamers

Victoria Kasprowicz, University of KwaZulu Natal, South Africa
A story of viral escape through sequence variation in chronic Hepatitis C Virus infection

Lars Frelin, Karolinska Institute, Sweden
Developing a therapeutic Hepatitis B Vaccine with Pro5® Pentamers

Ellie Barnes, University of Oxford, UK
Success for Hepatitis C Vaccine Trials at Oxford University



Jorge Almeida, INSERM, France
T cell vaccines for HIV-1 move a step closer – researchers use HIV-specific Pro5® MHC Class I Pentamers combined with intracellular cytokine staining

Aude Chapuis, Fred Hutchinson Cancer Research Center, USA
Sending in trained killers to attack residual HIV infection


Infectious Diseases

Ana Ferreira, Instituto Gulbekian de Ciência, Portugal
Researchers show how inheritance of Sickle Cell Anemia protects against Malaria infection



J Guo, University of Texas, USA
Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging

Roberto Mallone, Hôpital Saint Vincent de Paul, France
How does blood processing affect the results of cell-mediated immunity assays? ProImmune’s Flu Pro5® MHC Class I Pentamer is used as an exemplar in an exploratory study

Suryaprakash Sambhara, Centre for Disease Control and Prevention CDC, USA
Study on H5N1 vaccine uses Pro5® Pentamer to correlate immune response with protection


Mycobacterium tuberculosis

Sam Behar, Harvard Medical School, USA
A Messy End for TB-infected Macrophages



Bruce Blazar, University of Minnesota, USA
In Situ Identification of Allospecific B Cells using Pentamers


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