Publications Citing the Use of ProImmune Pro5 MHC Penatmers

Publications citing the use of ProImmune products

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Publications citing Pro5® MHC Pentamers

Autoimmunity

Lymphocytic Choriomeningitis Virus (LCMV)

Cancer

Listeria

Adenovirus

Malaria

Cytomegaolvirus (CMV)

Minor Histocompatibility Antigen (miHAg)

Epstein-Barr Virus (EBV)

Mycobacterium Tuberculosis

Hepatitis B (HBV)

Respiratory Syncytial Virus (RSV)

Hepatitis C (HCV)

Trypanosoma Cruzi

Human Immunodeficiency Virus (HIV)

Vaccinia Virus

Human T-lymphotropic Virus (HTLV)

Other

Influenza

Model Antigen

Autoimmunity

Monti, P. et al. (2008) Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J. Clin. Invest. 118: 1806-1814 [PubMedID: 18431516]

A*02:01/VMNILLQYV (GAD 65)

A*02:01/GILGFVFTL (Flu-A MP)

A*02:01/SLYNTVATL (HIV gag p17)

Monti, P. et al. (2007). Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J. Immunol. 179: 5785-92. [PubMedID: 17947651].

A*02:01/VMNILLQYV (GAD 65)

A*02:01/GILGFVFTL (Flu-A MP)

A*02:01/SLYNTVATL (HIV gag p17)

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Cancer

Ali, OA. et al. (2009) Infection-mimicking materials to program dendritic cells in situ. Nature Materials. 8: 151-158. [PubMedID: 19136947]

H-2Kb/SVYDFFVWL (TRP2)

Andersen, MH. et al. (2009). Identification of heme-oxygenase-1-specific regulatory CD8+T cells in cancer patients. J. Clin. Invest. 119: 2245-2256.[PubMedID: 19662679]

A*02:01/QLFEELQEL (Heme -oxygenase-1)

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/ILKEPVHGV (HIV-1 pol)

A*02:01/SLYNTVATL (HIV-1 gag)

Ansen, S. et al. (2008). Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin-21. Clin. Cancer Res. 14: 6125-6136 [PubMedID: 18829491]

A*02:01/ELAGIGILTV (MelanA/MART1)

Bergant, M. et al.(2006). Preparation of native and amplified tumour RNA for dendritic cell transfection and generation of in vitro anti-tumour CTL responses. Immunobiol. 211: 179-189. [[PubMedID:16530085].

A*02:01/YLSGANLNL (CEA)

Bolonaki, I. et al. (2007).Vaccination of patients with advanced non-small-cell lung cancer with an optimized cryptic human telomerase reverse transcriptase peptide. J. Clin. Oncol. 25: 2727-2734. [PubMedID: 17602077].

A*02:01/YLFFYRKSV (mTERT)

A*02:01/SMNTVATL (HIV gag)

Bracci, L. et al. (2008) Efficient stimulation of T cell responses by human IFN-a-induced dendritic cells does not require Toll-like receptor triggering. J Immunother. 31: 466-474. [PubMedID: 18463538]

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/GILGFVFTL (Inlfuenza MP)

A*02:01/YLEYRQVPV (MAGE)

Britten, CM. et al. (2009). Harmonization guidelines for HLA-peptide multimer assays derived from results of a large scale international proficiency panel of the cancer vaccine consortium. Cancer Immunol, Immunother. 58: 1701-1713.[PubMedID: 19259668]

A*02:01/GILGFVFTL (Influenza MP)

A*02:01/ELAGIGILTV (MelanA/MART-1)

Calderhead, DM. et al. (2008). Cytokine maturation followed by CD40L mRNA electroporation results in a clinically relevant dendritic cell product capable of inducing a potent proinflammatory CTL response. J Immunother. 31: 731-741.[PubMedID: 18779746]

A*02:01/ELAGIGILTV (MelanA/MART-1)

Carnevale-Schianca, F. et al. (2006). Allogeneic nonmyeloablative hematopoietic cell transplantation in metastatic colon cancer: tumor-specific T cells directed to a tumor-associated antigen are generated in vivo during GVHD. Blood 107: 3795-3803. [[PubMedID: 16403911]

A*02:01/YLSGANLNL (CEA)

A*02:01/NLVPMVATV(HCMV pp65)

A*02:01/ELAGIGILTV (MelanA / MART-1) - Negative control

Casado, JG. et al. (2009) Correlation of effector function with phenotype and cell division after in vitro differentiation of naive MART-1-specific CD8+ T cells. International Immunolgy. 21: 53-62.[PubMedID: 19050104]

A*02:01/ELAGIGILTV (MelanA/MART-1)

Cerullo et al. (2010) Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients.  Cancer Research 70: 4297-4309 [PubMedID: 20484030]

A*02:01/LMLGEFLKL (Survivin)

Chaise, C. et al. (2008). DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance. Blood. 112: 2956-2964.[PubMedID: 18502835]

A*02:01/RMFPNAPYL (WT-1)

A*02:01/CMTWNQMNL (WT-1)

Chiang, CL-L. et al. (2008). Oxidation of ovarian epithelial cancer cells by hypochlorous acid enhances immunogenicity and stimulates T cells that recognize autologous primary tumor. Clin. Cancer Res. 14: 4898-4907 [PubMedID: 18676764]

A*02:01/KIFGSLAFL (Her2/neu)

Cohen, C.J. et al. (2007). Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond. Cancer Res. 67: 3898-3903.[[PubMedID: 17440104]

A*02:01/LLGRNSFEV (p53)

Cohen, C.J. et al.(2006). Enhanced antitumor activity of murine-human hybrid T cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability.Cancer Res. 66: 8878-8886.[[PubMedID:16951205]

A*02:01/LLGRNSFEV (p53)

DeBenedette, MA. et al. (2008). Priming of a novel subset of CD28+ rapidly expanding high-avidity effector memory CTL by post maturation electroporation-CD40L dendritic cells is IL-12 dependent. J. Immunol. 181: 5296-5305 [PubMedID: 18832685]

A*02:01/ELAGIGILTV (MelanA/MART-1)

Domschke, C. et al. (2009). Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis. Cancer Res. 69: 8420-8428. [PubMedID: 19843863]

A*02:01/KIFGSLAFL (HER-2/neu)

Escors, D. et al. (2008). Targeting dendritic cell signalling to regulate the response to immunisation. Blood. 111: 3050-61. [ PubMedID: 18180378]

A*02:01/ELAGIGILTV (Melan-A/MART 1)

Foster, et al. (2010). Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L/IL-2 tumor vaccine. Leukemia. epub ahead of print [PubMedID:20072155]

A*02:01/ILSLELMKL (RHAMM)

Freeman, JL. et al. (2007) CMRF-56 immunoselected blood dendritic cell preparations activated with GM-CSF induce potent antimyeloma cytotoxic T-cell responses. J Immunother. 30: 740-748. [PubMedID: 17893566]

A*02:01/ELAGIGILTV (MelanA/MART-1)

Geiger, R. et al. (2009). Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells. J. Exp. Med. 206: 1525-1534. [PubMedID: 19564353]

A*02:01/ELAGIGILTV (MelanA/MART-1)

Gritzapis, AD. et al.(2008). Identification of a novel immunogenic HLA-A*02:01-binding epitope of HER-2/neu with potent antitumor properties. J Immunol. 181: 146-154 PubMedID: 18566379]

A*02:01/LIAHNQVRQV (Her-2(10))

Hardy, MY. et al. (2009) NK cells enhance the induction of CTL responses by IL-15 monocyte-derived dendritic cells. Immunol. and Cell Biol. 87: 606-614 [PubMedID: 19546878]

A*02:01/ELAGIGILTV (MelanA / MART-1)

Harrop, R. et al. (2007). Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses. Cancer Immunol. Immunother. 57: 977-986. [PubMedID: 18060404]

A*02:01/RLARLALVL (5T4)

A*02:01/FLTGNQALV (5T4)

He, L. et al.(2005). A sensitive flow cytometry-based cytotoxic T-lymphocyte assay through detection of cleaved caspase 3 in target cells. J. Imm. Methods 304: 43-59. [[PubMedID: 16076473]

A*02:01/SLYNTVATL (HIV-1 gag p17)

A*02:01/YLSGANLNL(CEA)

Himoudi, N. et al. (2008). MYCN as a target for cancer immunotherapy. Cancer Immunol. Immunother. 57: 693-700. [PubMedID: 18004567]

A*02:01/VILKKATEYN (MYCN)

Hirano, F. et al. (2005). Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 65: 1089-1096. [PubMedID: 15705911]

H-2Ld/LPYLGWLVF (Tumor antigen P815)

Koido, S. et al. (2010).  Dendritic/pancreatic carcinoma fusions for clinical use: Comparative functional analysis of healthy- versus patient-derived fusions.  Clinical Immunology. 135, 384-400. [PubMedID: 20226739]

A*02:01/RMFPNAPYL (WT1)

A*24:02/RMFPNAPYL (WT1)

A*02:01/YLSGANLNL (CEA)

Koido, S. et al. (2008). In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells. J. Translational Medicine. 6: 51 [PubMedID: 18793383]

A*02:01/RMFPNAPYL (WT1)

A*02:01/YLSGANLNL (CEA)

Koido, S. et al. (2007). Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells. J. Immunol. 179: 4874-83. [PubMedID: 17878387]

A*02:01/YLSGANLNL (CEA)

A*24:02/TYACFVSNL (CEA)

Koido, S. et al. (2006). Streptococcal preparation OK-432 promotes fusion efficiency and enhances induction of antigen-specific CTL by fusions of dendritic cells and colorectal cancer cells. J. Immunol. 178: 613-622. [PubMedID: 17182602]

A*02:01/STAPPVHNV (MUC-1)

A*02:01/YLSGANLNL (CEA)

A*24:02/TYACFVSNL (CEA)

Koido, S. et al. (2005). Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells. Clin. Cancer Res. 11: 7891-7900. [PubMedID: 16278414]

A*02:01/STAPPVHNV (MUC-1)

A*02:01/YLSGANLNL (CEA)

A*24:02/TYACFVSNL (CEA)

Krambeck, A.E. et al.(2007). Survivin and B7-H1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma. Clin. Cancer Res. 13: 1749-1756. [ [PubMedID: 17363528]

A*02:01/LMLGEFLKL (Survivin)

Kuball, J. et al. (2007). Facilitating matched pairing and expression of TCR chains introduced into human T cells. Blood 109: 2331-2338. [PubMedID:17082316]

Lopes, L. et al. (2008). Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses. J. Virol. 82: 86-95. [PubMedID: 17959670]

A2Kb/SLLMWITQV (NY-ESO157-165)

Mehrotra, S. et al. (2007). Inhibition of c-Jun N-terminal kinase (JNK) rescues influenza epitope-specific human cytolytic T lymphocytes (CTL) from activation-induced cell death (AICD). J. Leukoc. Biol. 81: 539-547. [[PubMedID: 17062604]

A*02:01/GILGFVFTL (Influenza A MP)

A*02:01/AAGIGILT (MelanA / MART-1)

Milne, K. et al. (2008) Tumor-infiltrating T cells correlate with NY-ESO-1 specific autoantibodies in ovarian cancer. PLoS ONE 3: e3409 [PubMedID: 18923710]

A*02:01/SLLMWITQV (NY-ESO-1)

Moeller, I. et al. (2008) Dendritic cell maturation with poly(I:C)-based versus PGE2-based cytokine combinations results in differential functional characteristics relevant to clinical application.; J Immunother. 31:506-519.[PubMedID: 18463533]

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/ALQPGTALL (prostate stem cell antigen)

A*02:01/KLVALGINAV (HCV NS3)

Norell, H. et al. (2009). Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-127-35-Reactive T cells from activation-induced cell death. Cancer Res. 69: 6282-6289 [PubMedID: 19638595]

A*02:01/ELAGIGILTV (MelanA/MART-1)

Pavlenko, M. et al. (2005). Identification of an immunodominant H-2Db-restricted CTL epitope of human PSA. Prostate 64: 50-59. [PubMedID: 15651071]

H-2Db/HCIRNKSVI (Prostate specific antigen)

Peng, PD. et al. (2009). Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity. Gene Therapy. 16: 1042-1049.[PubMedID: 19494842]

A*02:01/LLGRNSFEV (p53)

Prestwich, RJ. et al. (2008). Tumor infection by oncolytic reovirus primes adaptive antitumor immunity. Clin. Cancer Res. 14: 7358-7366[PubMedID: 19010851]

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/Negative

Provenzano, M. et al. (2006). Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*02:01+ BKV-seropositive donors. J. Transl. Med. 4: 47. [PubMedID: 17096832]

A*02:01/ELAGIGILTV (MelanA/MART 1)

A*02:01/VIFDFLHCI (BKV LTag)

A*02:01/LLLIWFRPV (BKV LTag)

Radford, KJ. et al. (2006). CD11c+ blood dendritic cells induce antigen-specific cytotoxic T lymphocytes with similar efficiency compared to monocyte-derived dendritic cells despite higher levels of MHC class I expression. J Immunother. 29: 596-605.[PubMedID: 17063122]

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/GILGFVFTL (Influenza MP)

Rosenthal, R. et al. (2009). Differential responsiveness to IL-2, IL-7 and IL-15 common receptor gchain cytokines by antigen-specific peripheral blood naive or memory cytotoxic CD8+ T cells from healthy donors and melanoma patients. J Immunother. 32: 252-261. [PubMedID: 19242375]

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/SLSAYIIRV (Vaccinia Virus H3L)

A*02:01/KVDDTFYYV (Vaccinia Virus C7L)

Sartorius, R. et al. (2008). The use of filamentous bacteriophage fd to deliver MAGE-A10 or MAGE-A3 HLA-A2-restricted peptides and to induce strong antitumor CTL responses. J. Immunol. 180: 3719-3728. [PubMedID: 18322177]

A*02:01/FLWGPRALV (MAGE-A3)

A*02:01/ILKEPVHGV (HIV-1 RT)

Sebestyén, Z. et al. (2008). Human TCR that incorporate CD3c induce highly preferred pairing between TCRa and b chains following gene transfer. J. Immunol. 180: 7736-7746. [PubMedID: 18490778]

A*02:01/YLEPGPVTA (gp100 (pmel17))

A*01:01/EADPTGHSY (MAGE-A1)

A*11:01/IVTDFVIK (EBV EBNA)

A*02:01/ELAGIGILTV (MelanA / MART-1)

Siegel, S. et al. (2006). Identification of HLA-A*02:01-presented T cell epitopes derived from the oncofetal antigen-immature Laminin receptor protein in patients with hematological malignancies. J. Immunol. 176: 6935-6944. [PubMedID:16709854]

Soeda, A. et al (2009). Regular dose of Gemcitabine induces an increase in CD14+ monocytes and CD11c+ dendritic cells in patients with advanced pancreatic cancer. Jpn. J. Clin. Oncol. 39: 797-806. [PubMedID: 19797418]

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/RMFPNAPYL (WT-1)

A*24:02/CMTWNQMNL (WT-1)

Stronen, E. et al (2009). Dendritic cells engineered to express defined allo-HLA peptide complexes induce antigen-specific cytotoxic T cells efficiently killing tumor cells. Scandinavian Journal of Immunology. 69: 319-328 [PubMedID: 19284496]

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/LLWAGALAM (CD33)

A*02:01/VLWHWLLRT (CD19)

A*02:01/NLVPMVATV (CMV pp65)

Theoret, MR. et al. (2008). Relationship of p53 overexpression on cancers and recognition by anti-p53 TCR transduced T cells. Human Gene Therapy. epub ahead of print. [PubMedID: 18707199]

A*02:01/LLGRNSFEV (p53)

A*02:01/KTWGQYWQV (gp100)

Wang, Z. et al.  (2010) Graft-versus-leukemia effects of Wilms' tumor 1 protein-specific cytotoxic T lymphocytes in patients with chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation.  Chin Med J 123: 912-916 [PubMedID: 20497687]

A*24:02/CMTWNQMNL (WT1 p235)

Weber, G. et al. (2009). WT1 peptide-specific T cells generated from peripheral blood of healthy donors: possible implications for adoptive immunotherapy after allogeneic stem cell transplantation. Leukemia. 23: 1634-1642 [PubMedID: 19357702]

A*02:01/RMFPNAPYL (WT1 p126)

A*02:01/CMTWNQMNL (WT1 p235)

Wenandy, L. et al. (2008). The immunogenicity of the hTERT540-548 peptide in cancer. Clin. Cancer Res. 14: 4-7. [PubMedID: 18172245]

A*02:01/ILAKFLHWL (hTERT)

West, E. et al. (2009) Clinical grade OK432-activated dendritic cells. In vitro characterization and tracking during intralymphatic delivery. J Immunother. 32: 66-78. [PubMedID: 19307995]

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/Negative

Wiesner, M. et al. (2008). Conditional immortalization of human B cells by CD40 ligation. PLoS ONE 3(1): e1464. [PubMedID: 18213373]

A*02:01/ELAGIGILTV (MelanA / MART-1)

A*02:01/CLGGLLTMV (EBV LMP-2)

Wilkinson, R. et al. (2006). Numerical and functional assessment of blood dendritic cells in prostate cancer patients. The Prostate 66: 180-192. [PubMedID: 16173035]

A*02:01/GILGFVFTL (Influenza A MP)

A*02:01/VISNDVCAQV (PSA-1)

Wolfl, M. et al. (2007). Activation-induced expression of CD137 permits detection, isolation and expansion of the full repertoire of CD8+ T-cells responding to antigen without requiring knowledge of epitope-specificities. Blood 110: 201-210. [PubMedID: 17371945]

A*02:01/ELAGIGILTV (MelanA / MART-1)

B*07:02/TPRVTGGGAM (HCMV pp65)

A*02:01/KLVALGINAV (HCV NS1)

Yagi, H. et al. (2006). Induction of therapeutically relevant cytotoxic T lymphocytes in humans by percutaneous peptide immunization. Cancer. Res. 66: 10136-10144. [PubMedID:17047078]

A*02:01/EYLQLVFGI (MAGE-2)

A*02:01/IMPKAGLLI (MAGE-3)

Yan, M. et al. (2008). Development of cellular immune responses against PAX5, a novel target for cancer immunotherapy. Cancer Res. 68: 8058-8065 [PubMedID: 18829564]

A*02:01/TLPGYPPHV (PAX5)

Yang, S. et al. (2008). Antigen-presenting cells containing multiple costimulatory molecules promote activation and expansion of human antigen-specific memory CD8+ T cells. Cancer Immunol. Immunother. 58: 503-513. [PubMedID: 18690438]

A*02:01/YLSGANLNL (CEA)

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Adenovirus

Finn, JD. et al. (2010). Proteasome inhibitors decrease AAV2 capsid-derived peptide epitope presentation on MHC class I following transduction. Molecular Therapy. 18: 135-142 [PubMedID:19904235]

B*07:02/VPQYGYLTL (AAV-2)

Fujita, Y. et al. (2008) Exploiting cytokine secretion to rapidly produce multivirus-specific T cells for adoptive immunotherapy. J Immunother. 31: 665-674. [PubMedID: 18600178]

B*35:01/MPNRPNYIAF (Adenovirus 5 Hexon)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/FLYALALL (EBV LMP-2)

A*02:01/CLGGLLTMV (EBV LMP-2)

Kaka, AS. et al. (2008). Using dendritic cell maturation and IL-12 producing capacity as markers of function: A cautionary tale. J Immunother. 31: 359-369. [PubMedID: 18391760]

A*01:01/TLDGQNLLY (Adenovirus 5 Hexon)

A*24:02/TYFSLNNKF (Adenovirus 5 Hexon)

Karlsson, H. et al. (2007) Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus and Epstein-Barr virus. J. Immunother. 30: 544-556. [PubMedID: 17589295]

A*02:01NLVPMVATV (HCMV pp65)

B*07:02/RPHERNGFTVL (HCMV pp65)

B*07:02/TPRVTGGGAM (HCMV pp65)

A*02:01/CLGGLLTMV (EBV LMP-2)

A*02:01/GLCTLVAML (EBV BMLF-1)

B*07:02/RPPIFIRRL (EBV EBNA-3A)

B*08:01/RAKFKQLL (EBV BZLF-1)

A*24:02/TYFSLNNKF (Adenovirus 5 Hexon)

A*01:01/TLDGQNLLY (Adenovirus 5 Hexon)

B*07:02/KPYSGTAYNAL (Adenovirus Hexon)

Leen, AM. et al. (2008). Identification of Hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy. J Virol. 82: 546-554. [PubMedID: 17942545]

A*24:02/TYFSLNNKF (Adenovirus 5 Hexon)

A*01:01/TLDGQNLLY (Adenovirus 5 Hexon)

B*07:02/KPYSGTAYNAL (Adenovirus Hexon)

B*35:01/MPNRPNYIAF (Adenovirus 5 Hexon)

Micklethwaite, KP. et al. (2008). Prophylactic infusion of cytomegalovirus-specific cytotoxic T lymphocytes stimulated with Ad5f35pp65 gene modified dendritic cells after allogeneic hemopoietic stem cell transplantation. Blood. 112: 3974-3981 [PubMedID: 18768783]

A*01:01/TDLGQNLLY (Adenovirus 5 Hexon)

Mingozzi, F. et al. (2007). CD8+ T-cell responses to adeno-associated virus capsid in humans. Nat. Med. 13: 419-422. [[PubMedID: 17369837]

B*07:02/VQPYGYLTL (AAV-2)

Pien, GC. et al. (2009). Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.Journal Clin. Invest. doi:10.1172/JCI36891. [PubMedID: 19436115]

A*01:01/SADNNNSEY (AAV-2)

B*07:02/VQPYGYLTL (AAV-2)

B*07:02/IPQYGYLTL (AAV-8)

B*07:02/IPRRIRQGL (HIV-1 env)

B*07:02/RPPIFIRRL (EBV EBNA-3A)

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Cytomegalovirus (CMV)

Böhm, V. et al. (2008). Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy. Med. Microbiol. Immunol. 197:135-144. [PubMedID:18340461]

H-2Ld/YPHFMPTNL (MCMV)

Bollard, C.M. et al. (2007).Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Blood. 110: 2838-45. [PubMedID: 17609424]

A*02:01/CLGGLLTMV (EBV LMP-2)

A*02:01/NLVPMVATV (HCMV pp65)

Brennan, R.M. et al. (2007).Predictable ab T cell receptor selection towards an HLA-B*35:01-restricted human cytomegalovirus epitope. J. Virol. 81: 7269-7273. [[PubMedID: 17459926]

B*35:01/IPSINVHHY(HCMV pp65)

Cantisan, S. et al. (2009). Age-dependent association between low frequency of CD27/CD28 expression on pp65 CD8+ T cells and cytomegalovirus replication after transplantation. Clin. Vaccine Immunol. 16: 1429-1438 [PubMedID: 19656991]

A*02:01/NLVPMVATV (CMV pp65)

Christmas, SE. et al. (2009). Cytomegalovirus-specific CD8+ T ells do not develop in all renal transplant patients at risk of virus infection. Transpl. Immunol. 22: 99-104 [PubMedID: 19635559]

A*02:01/NLVPMVATV (CMV pp65)

Crough, T. et al. (2007). Symptomatic and asymptomatic viral recrudescence in solid organ transplant recipients and its relationship with antigen-specific CD8+ T-cell response. J. Virol. 81: 11538-42. [PubMedID: 17686874]

A*02:01/NLVPMVATV (CMV pp65)

A*01:01/VTEMDTLLY (CMV pp50)

B*07:02/TPRVTGGGAM (CMV pp65)

Czesnikiewicz-Guzik, M. et al. (2008) T cell subset-specific susceptibility to aging.Clin Immunol. 127: 107-118 [[PubMedID: 18222733]

A*02:01/NLVPMVATV (CMV pp65)

Dander, E. et al. (2008). Characterization of migratory activity and cytokine profile of helper and cytotoxic CMV-specific T-cell lines expanded by a selective peptide library. Exp. Hematol. 36: 473-485. [PubMedID: 18261836]

A*02:01/NLVPMVATV (CMV pp65)

B*07:02/TPRVTGGGAM (CMV pp65)

B*07:02/RPHERNGFTVL (CMV pp65)

A*01:01/YSEHPTFTSQY (CMV pp65)

B*35:01/IPSINVHHY (CMV pp65)

Davies, JK. et al. (2008). Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of two phase I studies. Blood. 112: 2232-2241 [PubMedID: 18617635]

A*02:01/NLVPMVATV (CMV pp65)

Davies, JK et al (2008). Induction of alloanergy in human donor T cells without loss of pathogen or tumour immunity. Transplantation. 86: 854-864 [PubMedID: 18813111]

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/NLVPMVATV (CMV pp65)

Fujita, Y. et al. (2008) Exploiting cytokine secretion to rapidly produce multivirus-specific T cells for adoptive immunotherapy. J Immunother. 31: 665-674. [PubMedID: 18600178]

B*35:01/MPNRPNYIAF (Adenovirus 5 Hexon)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/FLYALALL (EBV LMP-2)

A*02:01/CLGGLLTMV (EBV LMP-2)

Gerdemann, U. et al. (2009). Nucleofection of DCs to generate multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host. Molecular Therapy. 17: 1616-1625. [PubMedID: 19584818]

A*02:01/NLVPMVATV (CMV pp65)

B*07:02/TPRVTGGGAM (CMV pp65)

Griffioen, M. et al (2008). Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application. Haematologica. 93: 1535-1543 [PubMedID: 18768532]

Hayashi, D. et al. (2008). Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-1-associated myelopathy. J Neuroimmunol. 200: 115-124 [PubMedID: 18639344]

A*02:01/LLFGYPVYV (HTLV Tax)

A*02:01/CLGGLLTMV (CMV LMP2)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/SLYNTVATL (HIV gag17)

Horlock, C. et al. (2009). ELISPOT and functional T cell analyses using HLA mono-specific target cells. J Immunol. Methods 350: 150-160. [PubMedID: 19729014]

Karlsson, H. et al. (2007) Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus and Epstein-Barr virus. J. Immunother. 30: 544-556. [PubMedID: 17589295]

A*02:0/NLVPMVATV (HCMV pp65)

B*07:02/RPHERNGFTVL (HCMV pp65)

B*07:02/TPRVTGGGAM (HCMV pp65)

A*02:01/CLGGLLTMV (EBV LMP-2)

A*02:01/GLCTLVAML (EBV BMLF-1)

B*07:02/RPPIFIRRL (EBV EBNA-3A)

B*08:01/RAKFKQLL (EBV BZLF-1)

A*24:02/TYFSLNNKF (Adenovirus 5 Hexon)

A*01:01/TLDGQNLLY (Adnovirus 5 Hexon)

B*07:02/KPYSGTAYNAL (Adenovirus Hexon)

Karlsson, H. et al. (2008). Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T cell responses. Blood 112: 532-541 [PubMedID: 18445691]

A*02:0/NLVPMVATV (HCMV pp65)

B*07:02/RPHERNGFTVL (HCMV pp65)

B*07:02/TPRVTGGGAM (HCMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

B*07:02/RPPIFIRRL (EBV EBNA-3A)

B*08:01/RAKFKQLL (EBV BZLF-1)

Leen, A.M. et al. (2006). Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat. Med. 12: 1160-1166. [PubMedID: 16998485]

A*02:01NLVPMVATV (HCMV pp65)

A*24:01/VYALPLKML (HCMV pp65)

A*24:01/QYDPVAALF (HCMV pp65)

B*07:02/RPHERNGFTVL (HCMV pp65)

B*07:02/TPRVTGGGAM (HCMV pp65)

Li Pira, G. et al. (2008) Positive selection and expansion of cytomegalovirus-specific CD4 and CD8 T cells in sealed systems. Potential applications for adoptive cellular immunoreconstitution. J Immunother. 31: 762-770. [PubMedID: 18779743]

A*02:01/NLVPMVATV (CMV pp65)

Li Pira, G. et al. (2008). Evaluation of antigen specific T-cell responses with a miniaturized and automated method. Clin. Vaccine Immunol. 15: 1811-1818 [PubMedID: 18945878]

A*02:01/NLVPMVATV (CMV pp65)

Li Pira, G. et al. (2006). A sealed and unbreached system for purification, stimulation, and expansion of cytomegalovirus-specific human CD4 and CD8 T lymphocytes. Transfusion 46: 2053-62. [PubMedID: 17176316]

A*02:01/NLVPMVATC (CMV pp65)

A*02:01/SLYNTVATL (HIV gag p17)

Martin-Donnaire, T. et al. (2009). Immune reconstitution after cord blood transplants supported by coinfusion of mobilized hematopoietic stem cells from a third party donor. Bone Marrow Transplantation. 44: 213-225 [PubMedID: 19252533]

A*02:01/NLVPMVATV (CMV pp65)

A*01:01/YSEHPTFTSQY (CMV pp65)

A*24:02/QYDPVAALF (CMV pp65)

A*24:02/VYALPLKML (CMV pp65)

B*35:01/IPSINVHHY (CMV pp65)

Mustjoki, S. et al. (2009) Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia. 23: 1398-1405 [PubMedID: 19295545]

Paine, A. et al. (2007). Expansion of human cytomegalovirus-specific T lymphocytes from unfractionated peripheral blood mononuclear cells with artificial antigen-presenting cells. Transfusion 47: 2143-52. ]PubMedID: 17958544]

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/VLHDDLLEA (HA-1) - Negative control

Perseghin, P. et al. (2008). Isolation of monocytes from leukapheretic products for large-scale GMP-grade generation of cytomegalovirus-specific T-cell lines by means of an automated elutriation device. Transfusion. 48: 1644-1649. [PubMedID: 18513258]

A*02:01/NLVPMVATV (CMV pp65)

Pita-Lopez, ML. et al. (2009). Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors. Immunity & Ageing. 6: 11 [PubMedID:19715573]

A*02:01/NLVPMVATV (CMV pp65)

Reker Hadrup, S. et al. (2006). Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J. Immunol. 176: 2645-2653.[PubMedID: 16456027]

A*02:01NLVPMVATV (HCMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/ILKEPVHGV (HIV-1 pol)

Rosenthal, R. et al. (2009). Differential responsiveness to IL-2, IL-7 and Il-15 common receptor g chain cytokines by antigen-specific peripheral blood naive or memory cytotoxic CD8+ T cells from healthy donors and melanoma patients. J Immunother. 32: 252-261. [PubMedID: 19242375]

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/SLSAYIIRV (Vaccinia Virus H3L)

A*02:01/KVDDTFYYV (Vaccinia Virus C7L)

Schub, A et al. (2009). CMV-specific TCR transgenic T cells for immunotherapy. J Immunol: 183: 6819-6830 [PubMedID: 19864595]

A*01:01/YSEHPTFTSQY (CMV pp65)

A*02:01/NLVPMVATV (CMV pp65)

B*35:01/IPSINVHHY (CMV pp65)

Schultz-Thater, E. et al. (2008). Whole blood assessment of antigen specific cellular immune response by real time quantitative PCR: a versatile monitoring and discovery tool. Journal of Translational Medicine. 6: 58 [PubMedID: 18925935]

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/GLCTLVAML (EBV BMLF1)

A*02:01/CLGGLLTMV (EBV LMP2)

A*02:01/GILGFVFTL (Influenza MP)

Schwanninger, A. et al. (2008). Age-related appearance of a CMV-specific high-avidity CD8+ T cells clonotype which does not occur in young adults. Immunity & Ageing. 5:14 [PubMedID: 19014475]

A*02:01/NLVPMVATV (CMV pp65)

Sester, U. et al. (2008). PD-1 expression and IL-2 loss of cytomegalovirus-specific T cells correlates with viremia and reversible functional anergy. Am J Transplant. 8: 1486-1497 [PubMedID: 18510628]

A*01:01/YSEHPTFTSQY (CMV pp65)

Suneetha, PV. et al. (2009). Effect of peptide pools on effector functions of antigen-specific CD8+ T cells. J Immunol. Methods 342: 33-48. [PubMedID: 19135447]

A*02:01/GILGFVFTL (Influenza MP)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/CINGVCWTV (HCV NS3)

Tanaka, K. et al. (2007). Role of the indigenous microbiota in maintaining the virus-specific CD8 memory T cells in the lung of mice infected with murine cytomegalovirus. J. Immunol. 178: 5209-5216. [PubMedID: 17404304]

H-2Ld/YPHFMPTNL (MCMV)

Tey, S-K. et al. (2007). Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biol. Blood Marrow Transplant. 13: 913-24. [PubMedID: 17640595]

B*08:01/RAKFKQLL (EBV BZLF-1)

A*02:01/NLVPMVATV (CMV pp65)

Waller, E. et al. (2007). Differential co-stimulation through CD137 (4-1BB) restores proliferation of human virus-specific "effector memory" (CD28-CD45RA hi) CD8+ T cells. Blood. 110: 4360-6. [PubMedID: 17878400]

A*02:01/NLVPMVATV (CMV pp65)

B*07:02/TPRVTGGGAM (CMV pp65)

Weinberger, B et al. (2009). CD28-CD8+ T cells do not contain unique clonotypes and are therefore dispensable. Immunol Lett. 127: 37-32 [PubMedID: 19715728]

A*02:01/NLVPMVATV (CMV pp65)

Widmann, T. et al. (2008) Levels of CMV specific CD4 T cells are dynamic and correlate with CMV viremia after allogeneic stem cell transplantation. PLoS ONE. 3: e3634 [PubMedID: 18982061]

A*01:01/YSEHPTFTSQY (CMV pp65)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/VLEETSVML (CMV 1E1)

B*07:02/TPRVTGGGAM (CMV pp65)

B*07:02/RPHERNGTVL (CMV pp65)

Wilson, J. et al. (2009). Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease. J. Exp. Med. 206: 387-398 [PubMedID: 19171763]

A*02:01/NLVPMVATV (CMV pp65)

Wynn, KK. et al. (2008). Impact of lonal competition for peptide-MHC complexes on CD8+ T cell repertoire selection in a persistent viral infection. Blood. 111: 4283-4292. [PubMedID: 18270323]

B*35:08/CPSQEPMSIYVY (CMV pp65)

B*35:08/FPTKDVAL (CMV pp65)

Yang, R. et al. (2008) Human Cytomegalovirus specific CD8+ T lymphocytes display interferon-g secretion impairment in kidney transplant recipients with pp65 antigenemia. Transplantation Proc. 40: 3500-3504 [PubMedID: 19100424]

A*02:01/NLVPMVATV (CMV pp65)

Yao, J. et al. (2008). Multimer staining of cytomegalovirus phosphoprotein 65-specific T cells for diagnosis and therapeutic purposes: a comparative study. Clin Infect Dis. 46:e96-105. [PubMedID: 18419478]

A*02:01NLVPMVATV (HCMV pp65)

B*07:02/TPRVTGGGAM (CMV pp65)

Zhang, J-Y. et al. (2008) Cutting Edge: Programmed Death-1 up-regulation is involved in the attrition of cytomegalovirus-specific CD8+ T cells in acute self-limiting hepatitis B virus infection. J. Immunol. 181: 3741-3744 [PubMedID: 18768824]

A*02:01/NLVPMVATV (CMV pp65)

Zhang, X. et al. (2006). Human bone marrow: A reservoir for 'enhanced effector memory' CD8+ T cells with potent recall function. J. Immunol. 177: 6730-6737. [[PubMedID: 17082586]

A*02:01/NLVPMVATV (CMV pp65)

Zhong, J. et al. (2008). Induction of pluripotent protective immunity following immunisation with a chimeric vaccine against human cytomegalovirus. PLoS one. 3:e3256 [PubMedID: 18806877]

A*02:01/NLVPMVATV (CMV pp65)

A*01:01/VTEHDTLLY (CMV pp50)

Wang, X. et al. (2007). Induction of potent CD8+ T cell responses by novel biodegradable nanoparticles carrying human immunodeficiency virus type I gp120. J. Virol. 81: 10009-16. [PubMedID: 17609261]

A*02:01/NLVPMVATV (CMV pp65)

B*07:02/TPRVTGGGAM (CMV pp65)

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Epstein-Barr Virus (EBV)

Archbold, J.K. et al. (2006).Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is resultant of highly focused, peptide-dependent structural mimicry. J.Biol. Chem. 281: 34324-34332. [PubMedID: 16963442]

B*08:01/FLRGRAYGL (EBV EBNA-3A)

Bell, MJ. et al. (2008) Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response. J. Infect. Dis. 197: 1594-1597 [PubMedID: 18419576]

B*08:01/YNLRRGIAL (EBV EBNA1)

B*08:01/YNLRRGTAL (EBV EBNA1)

Bell, MJ. et al. (2009) An HLA-A2-restricted T cell epitope mapped to the BNLF2a immune evasion protein of EBV that inhibits TAP. J Virol.83: 2783-2788 [PubMedID: 19129449]

A*02:01/VLFGLLCLL (EBV BNLF2a)

Bollard, C.M. et al. (2007). Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Blood. 110: 2838-45. [PubMedID: 17609424]

A*02:01/CLGGLLTMV (EBV LMP-2)

A*02:01NLVPMVATV (HCMV pp65)

Borg, N.et al. (2005). The CDR3 regions of an immunodominant T cell receptor dictate the ‘energetic landscape’ of peptide-MHC recognition. Nat. Immunol. 6: 171-180. [PubMedID:15640805]

B*08:01/FLRGRAYGL (EBV EBNA-3A)

Burrows, JM. et al. (2008) Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition. Mol. Immunol. 45: 1818-1824. [PubMedID: 17981331]

B*35:01/QPAPENAYQAY (EBV BZLF)

Davies, JK et al (2008). Induction of alloanergy in human donor T cells without loss of pathogen or tumour immunity. Transplantation. 86: 854-864 [PubMedID: 18813111]

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/NLVPMVATV (CMV pp65)

de Angelis, B. et al. (2009) Generation of Epstein-Barr virus specific cytotoxic T lymphocytes resistant to the immunosuppresive drug tacrolimus (FK506). Blood. 114: 4784-4791 [PubMedID:19759356]

A*11:01/IVTFDSVIK (EBV EBNA3B)

A*11:01/AVFDRKSDAK (EBV EBNA3B)

B*08:01/QAKWRLQTL (EBV EBNA3A)

B*08:01/RAKFKQLL (EBV BZLF1)

Elliott, S. et al. (2007). A phase I trial of a CD8+ T cell peptide epitope-based vaccine for infectious mononucleosis. J. Virol. 82: 1448-57. [PubMedID: 18032491]

B*08:01/FLRGRAYGL (EBV EBNA-3A)

B*08:01/RAKFKQLL (EBV BZLF-1)

Fujita, Y. et al. (2008) Exploiting cytokine secretion to rapidly produce multivirus-specific T cells for adoptive immunotherapy. J Immunother. 31: 665-674. [PubMedID: 18600178]

B*35:01/MPNRPNYIAF (Adenovirus 5 Hexon)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/FLYALALL (EBV LMP-2)

A*02:01/CLGGLLTMV (EBV LMP-2)

Gandhi, M.K. et al. (2007). Galectin-1 mediated suppression of EBV-specific T-cell immunity in classical Hodgkin-s lymphoma. Blood 110: 1326-9. [[PubMedID: 17438085]

A*02:01/CLGGLLTMV (EBV LMP-2)

Gandhi, M.K. et al. (2007). Immunity, homing and efficacy of allogeneic adoptive immunotherapy for posttransplant lymphoproliferative disorders. Am. J. Transplant. 7: 1293-1299. [PubMedID: 17425621]

B*08:01/FLRGRAYGL (EBV EBNA-3A)

Gandhi, M.K. et al. (2006). Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T cell function in Hodgkin lymphoma patients. Blood 108: 2280-2289. [PubMedID: 16757686]

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/CLGGLLTMV (EBV LMP-2)

B*07:02/RPPIFIRRL (EBV EBNA-3A)

B*08:01/FLRGRAYGL (EBV EBNA-3A)

B*08:01/RAKFKQLL (EBV BZLF-1)

Griffioen, M. et al (2008). Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application. Haematologica. 93: 1535-1543 [PubMedID: 18768532]

Han, S. et al. (2009). Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications. J. Hematol & Oncol. 2: 34. [PubMedID:19660111]

A*24:02/TYGPVFMCL (EBV LMP2)

Hart, D P. et al (2008). Retroviral transfer of a dominant TCR prevents surface expression of a large proportion of the endogenous TCR repertoire in human T cells. [PubMedID: 18305579]

A*02:01/CLGGLLTMV (EBV LMP-2)

Hofer, S. et al. (2005). Dendritic cells regulate T-cell de-attachment through the integrin-interacting protein CYTIP. Blood 107: 1003-1009. [PubMedID: 16204317]

A*02:01/GLCTLVAML (EBV BMLF-1)

Jarvis, LB. et al. (2008) Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells. Human Immunology. 69:687-695 [PubMedID: 18817831]

Karlsson, H. et al. (2007) Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus and Epstein-Barr virus. J. Immunother. 30: 544-556. [PubMedID: 17589295]

A*02:01NLVPMVATV (HCMV pp65)

B*07:02/RPHERNGFTVL (HCMV pp65)

B*07:02/TPRVTGGGAM (HCMV pp65)

A*02:01/CLGGLLTMV (EBV LMP-2)

A*02:01/GLCTLVAML (EBV BMLF-1)

B*07:02/RPPIFIRRL (EBV EBNA-3A)

B*08:01/RAKFKQLL (EBV BZLF-1)

A*24:02/TYFSLNNKF (Adenovirus 5 Hexon)

A*01:01/TLDGQNLLY (Adnovirus 5 Hexon)

B*07:02/KPYSGTAYNAL (Adenovirus Hexon)

Karlsson, H. et al. (2008). Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T cell responses. Blood 112: 532-541 [PubMedID: 18445691]

A*02:01NLVPMVATV (HCMV pp65)

B*07:02/RPHERNGFTVL (HCMV pp65)

B*07:02/TPRVTGGGAM (HCMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

B*07:02/RPPIFIRRL (EBV EBNA-3A)

B*08:01/RAKFKQLL (EBV BZLF-1)

Landmeier, S. et al. (2009). Activated humangd T cells as stimulators of specific CD8+ T-cell responses to subdominant Epstein Barr virus epitopes. J. Immunother. 32: 310-321. [PubMedID: 19242369]

A*02:01/FLYALALLL (EBV LMP-2)

B*08:01/RAKFKQLL (EBV BZLF-1)

Lehner, M. et al. (2007). Efficient chemokine-dependent migration and primary and secondary IL-12 secretion by human dendritic cells stimulated through Toll-like receptors. J Immunother. 30: 312-322. [PubMedID: 17414322]

A*02:01/GLCTLVAML (EBV BMLF-1)

Louis, CU. et al. (2008). Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients. Blood. 113: 2442-2450. [PubMedID: 18971421]

A*11:01/AVFDRKSDAK (EBV EBNA3B)

Lutzky, VP. et al. (2009). Optimization of LMP-specific CTL expansion for potential adoptive immunotherapy in NPC patients. Immunol & Cell Biol. 87: 481-488.[PubMedID: 19468283]

A*11:01/SSCSSCPLSK (EBV LMP-2)

Miles, J.J. et al. (2006). TCRa genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope. J. Immunol. 177: 6804-6814. [PubMedID: 17082594]

B*35:01/HPVGEADYFEY (EBV EBNA-1)

Mustjoki, S. et al. (2009) Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia. epub ahead of print. [PubMedID: 19295545]

Nehring, A.K. et al. (2007). Epstein-Barr virus T-cell immunity despite rituximab. Br. J. Haematol. 136: 628-632. [PubMedID: 17223914]

B*08:01/FLRGRAYGL (EBV EBNA-3A)

Reker Hadrup, S. et al. (2006). Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J. Immunol. 176: 2645-2653. [PubMedID: 16456027]

A*02:01NLVPMVATV (HCMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/ILKEPVHGV (HIV-1 pol 476-484)

Schultz-Thater, E. et al. (2008). Whole blood assessment of antigen specific cellular immune response by real time quantitative PCR: a versatile monitoring and discovery tool. Journal of Translational Medicine. 6: 58 [PubMedID: 18925935]

A*02:01/NLVPMVATV (CMV (pp65)

A*02:01/GLCTLVAML (EBV BMLF1)

A*02:01/CLGGLLTMV (EBV LMP2)

A*02:01/GILGFVFTL (Influenza MP)

Smith, C. et al. (2009) Discerning regulation of cis- and trans-presentation of CD8+ T-cell epitopes by EBV-encoded oncogene LMP-1 through self aggregation. Blood. 113: 6148-6152. [PubMedID: 19372256]

B*35:01/YPLHEQHGM (EBV EBNA-3A)

B*35:01/IPSINVHHY (CMV pp65)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01 YLQQNWWTL (EBV LMP-1)

A*02:01/CLGGLLTMV (EBV LMP-2)

Smith, C. et al. (2009). Acquisition of polyfunctionality by Epstein-Barr virus-specific CD8+ T cells correlates with increased resistance to galectin-1 mediated suppression. J Virol. 83: 6192-6198. [PubMedID: 19357166]

A*02:01/CLGGLLTMV (EBV LMP-2)

B*08:01/FLRGRAYGL (EBV EBNA-3A)

Smith, C. et al.(2006).; Functional reversion of antigen-specific CD8+ T cells from patients with Hodgkin lymphoma following in vitro stimulation with recombinant polyepitope. J. Immunol. 177: 4897-4906. [PubMedID: 16982932]

A*02:01/CLGGLLTMV (EBV LMP-2)

B*35:01/HPVGEADYFEY (EBV EBNA-1)

Suneetha, PV. et al. (2009). Effect of peptide pools on effector functions of antigen-specific CD8+ T cells. J Immunol. Methods 342: 33-48. [PubMedID: 19135447]

A*02:01/GILGFVFTL (Influenza MP)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/CINGVCWTV (HCV NS3)

Tellam, J. et al. (2007). Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes. J. Exp. Med. 204: 525-532. [PubMedID: 17312009]

B*08:01/FLRGRAYGL (EBV EBNA-3A)

Tellam, J. et al. (2007). Translation efficiency of EBNA1 encoded by lymphocryptoviruses influences endogenous presentation of CD8+ T cell epitopes. Eur. J. Immunol. 37: 328-337. [PubMedID: 17236233]

B*08:01/FLRGRAYGL (EBV EBNA-3A)

Tellam, J. et al. (2008). Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition. PNAS. 105: 9319-9324 [PubMedID: 18591662]

B*35:08/HPVGEADYFEY (EBV EBNA1)

Tey, S-K. et al. (2007). Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biol. Blood Marrow Transplant. 13: 913-24. [PubMedID: 17640595]

B*08:01/RAKFKQLL (EBV BZLF-1)

A*02:01/NLVPMVATV (CMV pp65)

Tuuminen, T. et al. (2007). Human CD8 T cell memory generation in Puumala Hantavirus infection occurs after the acute phase and is associated with boosting of EBV-specific CD8 memory T cells. J.Immunol. 179: 1988-1995.

A*02:01/GLCTLVAML (EBV BMLF-1)

Tynan, F.E. et al. (2007). A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatability complex class I molecule. Nat. Immunol 8: 268-276. [PubMedID: 17259989]

Tynan, F.E. et al. (2005). T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat. Immunol. 6: 1114-1122. [PubMedID: 16186824]

Vera, JF. et al. (2009). Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7. Molecular Therapy.17: 880-888.[PubMedID: 19259067]

B*08:01/RAKFKQLL (EBV BZLF-1)

B*08:01/QAKWRLQTL (EBV EBNA-3A)

A*02:01/GLCTLVAML (EBV BMLF-1)

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Hepatitis B Virus (HBV)

Boettler, T. et al. (2006). Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionality and phenotypically defined memory T cells during acute resolving hepatitis B virus infection. J. Virology. 80: 3532-3540. [PubMedID:16537621

A*02:01/FLPSDFFPSV (HBV core)

A*02:01/FLLTRILTI (HBV envelope)

A*02:01/WLSLLVPFV (HBV surface antigen)

A*02:01/GLSRYVARL (HBV polymerase)

Chen, W. et al. (2008). HBcAg-pulsed dendritic cell vaccine induces Th1 polarization and production of hepatitis B virus-specific cytotoxic T lymphocytes. Hepatology Research. epub ahead of print

A*02:01/FLPSDFFPSV (HBV core)

Chen, W. et al. (2008) Activated plasmacytoid dendritic cells act synergistically with hepatitis B core antigen-pulsed monocyte-derived dendritic cells in the induction of hepatitis B virus-specific CD8 T-cell response. Clinical Immunol. 129-295-303 [PubMedID: 18774748]

A*02:01/FLPSDFFPSV (HBV core)

Evans, A. et al. (2008). Programmed death 1 (PD-1) expression during antiviral treatment of chronic hepatitis B: Impact of HBeAg Seroconversion. Hepatology. 48: 759-769 [PubMedID: 18697210]

A*02:01/FLPSDFFPSV (HBV core)

A*02:01/FLLTRILTI (HBV sAg)

A*02:01/NLVPMVATV (CMV pp65)

Gehring, A.J. et al. (2007). The level of viral antigen presented by hepatocytes influences CD8 T cell function. J. Virol. 81: 2940-2949. [PubMedID: 17202217]

Nystrom, J. et al. (2010) Improving on the Ability of Endogenous Hepatitis B Core Antigen to Prime Cytotoxic T Lymphocytes.  Journal of Infectious Diseases 201: 1867-1879 [PubMedID:20446851]

H-2Kb/MGLKFRQL (HBcAg 93-100

Komatsu, H. et al .(2010).  Cellular immunity in children with successful immunoprophylactic treatment for mother-to-child transmission of hepatitis B virus.  BMC Infectious Diseases 10: 103-113 [PubMedID:20423521]

A*24:02/EYLVSFGVW (HBV pol 756-764)

A*24:02/KYTSFPWLL (HBV core 117-125)

Liu, H-G. et al. (2007). The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope. Clin. Immunol. 125: 337-45. [PubMedID:17900990]

A*02:01/FLPSDFFPSV (HBV core)

A*02:01/FLPSDFFPSI (HBV core)

Lopes, AR. et al. (2008). Bim-mediated deletion of antigen-specific CD8+ T cells in patients unable to control HBV infection. J. Clin. Invest. 118: 1835-1845 [PubMedID: 18398508]

A*02:01/FLPSDFFPSV (HBV core)

A*02:01/FLLTRILTI HBV env)

A*02:01/GLSRYVARL (HBV pol)

A*02:01/GILGFVFTL (Influenza MP)

Peng, G. et al. (2007). PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol. Immunol. 45: 963-70. [PubMedID:17868872]

A*02:01/FLPSDFFPSV (HBV core)

A*11:01/YVNVNMGLK (HBV core)

Phillips, S. et al. (2010). CD8+ T cell control of hepatitis B virus replication: direct comparison between cytolytic and noncytolytic functions. J. Immunol. 184: 287-295 [PubMedID:19949099]

A*02:01/FLPSDFFPSV (HBV core)

Schirmbeck, R. et al. (2008). The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigens. Molecular Therapy. 16: 1609-1616 [PubMedID: 18612271]

H-2Ld/IPQSLDWWTSL (HBV SAg)

Wieland, A. et al. (2009). Silencing an immunodominant epitope of hepatitis B surface antigen reveals and alternative repertoire of CD8 T cell epitopes of this viral antigen. Vaccine. 23: 114-119 [PubMedID: 19818719]

H-2Ld/IPQSLDWWTSL (HBV SAg)

Wortmann, A. et al. (2007). Fully detargeted polyethylene glycol-coated adenovirus vectors are potent genetic vaccines and escape from pre-existing anti-adenovirus antibodies. Mol. Ther. 16: 154-62. [PubMedID: 17848961

H-2Ld/IPQSLDSWWTSL (HBV surface antigen )

Zhang, Z. et al. (2009) Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell developmet in acute self-limited hepatitis B patients. J. Hepatol. 50: 1163-1173 [PubMedID: 19395117]

A*02:01/FLLTRILTI (HBV env)

A*02:01/WLSLLVPFV (HBV SAg)

A*02:01/FLLSLGIHL (HBV pol)

A*02:01NLVPMVATV (CMV pp65)

A*02:01/GILGFVFTL (Influenza MP)

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Hepatitis C Virus (HCV)

Caetano, J. et al. (2008). Differences in Hepatitis C Virus (HCV)-specific CD8 T-cell phenotype during pegylated alpha interferon and ribavirin treatment are related to response to antiviral therapy in patients chronically infected with HCV . J.Virol. 82: 7567-7577. [PubMedID:18480446]

A*02:01/CINGVCWTV (HCV N53)

A*02:01/DLMGYIPAV (HCV core)

Fytili, P. et al. (2008) Cross-genotype-reactivity of the immunodominant HCV CD8 T-cell epitope NS3-1073. Vaccine. 26: 3818-3826 [PubMedID: 18582999]

A*02:01/CINGVCWTV (HCV NS3)

Golden-Mason, L. et al.(2008). Cutting Edge: Programmed Death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: Race-dependent differences. J. Immunol. 180: 3637-3641. [PubmedID: 18322167]

B*35:01/HPNIEEVAL (HCV NS3)

Golden-Mason, L. et al. (2007). Upregulation of PD-1 expression on circulating and intrahepatic HCV-specific CD8+ T cells associated with reversible immune dysfunction. J. Virol. 81: 9249-58. [PubMedID:17567698]

Jeong, H-Y. et al. (2007). Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection. J. Leukoc. Biol. 83: 755-64. [PubMedID:18086898]

A*02:01/CINGVCWTV (HCV N53)

Golden-Mason, L. et al. (2009) Negative immune regulatory Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J. Virol. 83: 9122-9130 [PubMedID:19587053]

A*02:01/KLVALGINAV (HCV NS3)

A*02:01/CINGVCWTV (HCV NS3)

Kasprowicz, V. et al. (2007). High PD-1 expression on HCV-specific CD8+ and CD4+ T cells during acute Hepatitis C irrespective of clinical outcome. J. Virol. 82: 3154-60. [PubMedID:18160439]

A*02:01/CINGVCWTV(HCV N53)

A*02:01/KLVALGINAV

Kasprowicz, V. et al 2008). Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. J. Clin.Invest. 118: 1143-1153 [PubMedID:18246203]

A*02:01/GILGFVFTL (Influenza MP)

A*02:01/CVNGSCFTV (Influenza NA)

Kasprowicz, V. et al (2010). HCV sequence variation induces an HCV-specific T cell phenotype analogous to spontaneous resolution. J. Virol. 84: 1656-1663 [PubMedID: 19906915]

A*01:01/ATDALMGTY (HCV NS3)

A*02:01/CINGVCWTV (HCV NS3)

A*02:01/GLQDCTMLV (HCV NS5B)

B*07:02/GPRLGVRAT (HCV core)

Langhans, B. et al. (2006). Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2.Vaccine 24: 3066-3075. [PubMedID: 16504351]

A*02:01/YLLPRRGPRL (HCV core)

Rutebemberwa, A. et al. (2008). High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. J. Immunol. 181: 8215-8225 [PubMedID: 19050238]

A*01:01/ATDALMTGY (HCV NS3)

A*02:01/RLWHYPCTV (HCV E23)

Smyk-Pearson, S. et al. (2008). Spontaneous recovery in acute human HCV infection: functional T cell thresholds and relative importance of CD4 help. J. Virol. 82: 1827-37. [PubMedID:18045940

A*02:01/CINGVCWTV

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Human Immunodeficiency Virus (HIV)

Almeida, J. et al. (2007). Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J. Exp. Med. 204: 2473-85. [PubMedID:17893201]

B*2705/KRWIILGLNK (HIV-1 gag p24)

A*03:01/QVPLRPMTYK (HIV-1 nef)

A*03:01/RLRPGGKKK (HIV-1 gag p17)

B*07:02/GPGMKARVL (HIV-1 gag)

Andersen, MH. et al. (2005). Spontaneous immunity against Bcl-XL in cancer patients.J. Immunol. 175: 2709-2714. [PubMedID:16081848

A*02:01/ILKEPVHGV (HIV-1 pol)

Bailey, JR. et al. (2008). Transmission of human immunodeficiency virus type I from a patient who developed AIDS to an elite suppressor. J Virol. 82: 7395-7410 [PubMedID: 18495769]

B*27:05/KRWIILGLNK (HIV-1 gag p24)

Bridgeman, A. et al. (2009). Ovine atadenovirus, a novel and highly immunogenic vector in prime-boost studies of a candidate HIV-1 vaccine. Vaccine. 28: 474-483 [PubMedID:19853074]

H-2Kd/AMQMLKETI (HIV-1)

Brockman, MA. et al. (2009). IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood. 114: 346-356. [PubMedID:19365081]

A*02:01/SLYNTVATL (HIV-1 gag)

B*27:05/KRWIILGLNK (HIV-1 gag)

Cooper, D. et al. (2008). Attenuation of recombinant vesicular stomatitis virus-human immunodeficiency virus type 1 vaccine vectors by gene translocations and G gene truncation reduces neurovirulence and enhances immunogenicity in mice. J. Virol. 82: 207-19. [PubMedID:17942549]

H-2Kd/AMQMLKETI (HIV gag)

Cottingham, M.G. et al. (2006). Different levels of immunogenicity of two strains of Fowlpox virus as recombinant vaccine vectors eliciting T-cell responses in heterologous prime-boost vaccination strategies. Clin. Vaccine Immunol. 13: 747-757. [PubMedID: 16829611]

H-2Dd/RGPGRAFVTI (HIV-1 gp120

Decrion, A.Z. et al. (2007). A subset of functional effector-memory CD8+ T lymphocytes in human immunodeficiency virus-infected patients. Immunology 121: 405-15. [PubMedID:17376193]

A*02:01/ILKEPVHCV (HIV Pol)

A*02:01/SLYNTVATL (HIV gag)

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/NLVPMVATV (CMV pp65)

Earl, PL. et al. (2009). Design and evaluation of multi-gene, multi-clade HIV-1 MVA vaccines. Vaccine. 27: 5885-5895. [PubMedID: 19654066]

H-2Kd/AMQMLKETI (HIV-1)

Harari, A. et al. (2008). An HIV-1 clade C DNA prime, NYVAC boost regimen induces reliable, polyfunctional, and long-lasting T cell responses. J Exp Med. 205: 63-77 [PubMedID: 18195071]

A*01:01/YSENSSEYY (HIV-1 env)

Jones, RB. et al. (2008). Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frqeuencies in progressive HIV-1 infection. J. Exp. Med. 205: 2763-2779 [PubMedID: 19001139]

A*02:01/NLVPMVATV (CMVpp65)

A*02:01/GLCTLVAML (EBV BMLF1)

A*02:01ILKEPVHGV (HIV-1 Pol)

A*02:01/SLYNTVATL (HIV-1 gag17)

B*07:02/TPRVTGGGAM (CMV pp65)

Lecuroux, C. et al. (2009). Identification of a particular HIV-specific CD8+ T cells subset with a CD27+ CD45RO-/RA+ phenotype and memory characterisation after initiation of HAART during acute primary HIV infection. 113: 3209-3217 [PubMedID: 19098272]

A*02:01/SLYNTVATL (HIV-1 gag)

A*02:01/ILKEPVHGV (HIV-1 pol)

A*03:01/RLRPGGKKK (HIV-1 gag)

A*03:01/QVPLRPMTYK (HIV-1 nef)

A*24:02/RYPLTFGWCY (HIV-1 nef)

B*07:02/IPRRIRQGL (HIV-1 env)

B*08:01/GEIYKRWII (HIV-1 gag)

B*08:01/FLKEKGGL (HIV-1 nef)

B*27:05KRWIILGLNK (HIV-1 gag)

A*02:01/GLCTLVAML (EBV BMLF-1)

B*08:01/RAKFKQLL (EBV BZLF-1)

Lichterfeld, M. et al. (2008). Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1in progressors. Blood. 112: 3679-3687 [PubMedID: 18728248]

Lichterfield, M. et al. (2007). A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells. J. Exp. Med. 204: 2813-24. [PubMedID:18025130]

B*27:05/KRWIILGLNK (HIV-1 gag)

B*27:05/KRWIIMGLNK HIV-1 gag)

Rawson, P.M. et al. (2007). Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection. Nat. Med. 13: 1431-1439. [PubMedID:18026114

A*02:01/LLQDSVDFSL (Vimentin)

A*02:01/QLFNHTMFI (Non-muscle myosin)

A*02:01/VLMIKALEL (Non-muscle myosin)

A*02:01/FLGMESCGI (Actin)

Saez-Cirion, A. et al. (2009). Heterogeneity in HIV Suppression by CD8 T cells from HIV controllers: Association with gag-specific CD8 T cell responses. J. Immunol. 182: 7828-7837. [PubMedID: 19494307]

A*02:01/SLYNTVATL (HIV-1 gag)

A*02:01/ILKEPVHGV (HIV-1 pol)

A*03:01/RLRPGGKKK (HIV-1 gag)

A*03:01/QVPLRPMTYK (HIV-1 nef)

B*27:05/KRWIILGLNK (HIV-1 gag)

Salisch, NC. et al. (2010). Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1. J Immunol. 184: 476-487. [PubMedID: 19949078]

A*02:01/SLYNTVATL (HIV-1 gag)

A*03:01/RLRPGGKKK (HIV-1 gag)

A*03:01/QVPLRPMTYK (HIV-1 nef)

B*07:02/IPRRIRQGL (HIV-1 env)

B*08:01/EIYKRWII (HIV-1 gag)

B*08:01/FLKEKGGL (HIV-1 nef)

B*27:05/KRWIILGLNK (HIV-1 gag)

Shephard, E. et al. (2008). A multigene HIV type 1 subtype C modified vaccinia ankara (MVA) vaccine efficiently boosts immune responses to a DNA vaccine in mice. AIDS Res. Hum. Retroviruses. 24: 207-217. [PubMedID:18240963]

H-2Dk/VYYDPSKDLIA (HIV-RT)

H-2Dd/RGPGRAFVTI (HIV-env)

Streeck, H. et al. (2008). Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Medicine. 5: e100 [PubMedID: 18462013]

Streeck, H. et al. (2008). Immune-driven recombination and loss of control after HIV superinfection. J Exp. Med. 205: 1789-1796 [PubMedID: 18625749]

B*27:05/KRWIIMGLNK (HIV-1 gag p24)

Vali, B. et al. (2008). HIV-specific T-cells accumulate in the liver in HCV/HIV co-infection. PLoS one. 3: e3454. [PubMedID: 18941622]

Yu, X. et al. (2007). Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain. J. Virol. 81: 12666-9. [PubMedID: 17804503]

B*40:01/IEELRQHLL (HIV-1 pol)

B*40:01/IETVPVKL (HIV-1 pol)

B*40:01/KEKGGLEGL (HIV-1 nef)

A*02:01/YTAFTIPSV (HIV-1 pol)

A*02:01/SLYNTVATL (HIV-1 gag)

Zhang, J-Y. et al. (2007). PD-1 upregulation is correlated with HIV-specific memory CD8+ T cell exhaustion in typical progressors, but not in long-term non-progressors. Blood 109:4671-4678. [PubMedID:17272504]

A*02:01/SLYNTVATL (HIV-1 gag p17)

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Human T-lymphotropic Virus (HTLV)

Hayashi, D. et al.(2008). Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-1-associated myelopathy. J Neuroimmunol. 200: 115-124 [PubMedID: 18639344]

A*02:01/LLFGYPVYV (HTLV Tax)

A*02:01/CLGGLLTMV (CMV LMP2)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/SLYNTVATL (HIV gag17)

Manuel, SL. et al. (2009). Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: the underlying mechanism of HTLV-1-associated neuroinflammatry disease. J. Leukoc. Biol. 86: 86: 1205-1216 [PubMedID: 19656902]

A*02:01/LLFGYPVYV (HTLV-1 Tax)

Matsuura, E. et al. (2008). Inclusion body myositis associated with human T-lymphotropic virus-type I infection: Eleven patients from an endemic area in Japan. J Neuropathol Exp Neurol. 67: 41-49. [PubMedID: 19656902]

A*02:01/LLFGYPVYV (HTLV Tax)

A*02:01/GILGFVFTL (Influenza MP)

Oliveira, ALA. et al (2009). High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 (HTLV-2) infection. J Immunol. 183: 2957-2965 [PubMedID: 19657093]

A*02:01/LLYGYPVYV (HTLV-2 Tax-2)

A*02:01/NLVPMVATV (CMV pp65)

A*03:01/ILRGSVAHK (Influenza NP)

B*35:01/IPSINVHHY (CMV pp65)

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Influenza

Afonso, G., et al. (2010) Critical parameters in blood processing for T-cell assays: Validation on ELISpot and tetramer platforms.  Journal of Immunological Methods (in press)

A*02:01/GILGFVFTL (Influenza A MP)

Avetisyan, G. et al. (2008). Evaluation of immune responses to seasonal influenza vaccination in healthy volunteers and in patients after stem cell transplantation. Transplantation. 86:257-263 [PubMedID: 18645488]

A*01:01/ILRGSVAHK (Influenza NP)

A*02:01/GILGFVFTL (Influenza MP)

A*03:01/CTELKLSDY (Inlfuenza NP)

Bannard, O. et al. (2009) Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science. 323: 505-509. [PubMedID: 19164749]

H-2Db/ASNENMETM (Influenza NP PR8)

Bengsch, B. et al.& (2007). Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J. Virology. 81: 945-953. [PubMedID: [17079288]

A*02:01/GILGFVFTL (Influenza A MP)

Bohana-Kashtan, O. et al (2009). Selective reduction of graft-versus-host disease-mediating human T cells by ex vivo treatment with soluble Fas ligand. J. Immunol. 183: 696-705 [PubMedID: 19535642]

A*02:01/GILGFVFTL (Influenza MP)

B*07:02/RPPIFIRRL (EBV EBNA-3)

Currie, AJ. et al. (2009) Dual Control of Antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: Regulation and counterregulation. J. Immunol. 183: 7898-7908. [PubMedID: 20007574]

H-2Kd/IYSTVASSL (Influenza HA)

DiNapoli, JM. et al. (2008). Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection. Virology Journal. 5: 105 [PubMedID: 18816384]

H-2Kd/TYQRTRALV (Influenza NP)

H-2Kd/SYIGSINNI (RSV M2)

Fiore, F. et al. (2007). Enhanced ability of dendritic cells to stimulate innate and adaptive immunity upon short-term incubation with zoledronic acid. Blood 110: 921-7. [PubMedID: 17403919]

A*02:01/GILGFVFTL (Influenza A MP)

Hoelscher, M.A. et al. (2007). New pre-pandemic influenza vaccines: an egg- and adjuvant-independent human adenoviral vector strategy induces long-lasting protective immune responses in mice. Clin. Pharmacol. Ther. 82: 665-71. [PubMedID: 17957181]

H-2Kd/IYSTVASSL (Influenza A HA)

H-2Kd/TYQRTRALV (Influenza A (PR8) NP)

Hoelscher, M.A. et al. (2006). Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice. The Lancet 367: 475-481. [PubMedID: 16473124]

H-2Kd/IYSTVASSL (Influenza A HA)

Liu, Y. et al. (2006). Regulated Expression of Fc{gamma}R in Human Dendritic Cells Controls Cross-Presentation of Antigen-Antibody Complexes. J. Immunol. 177: 8440-8447. [PubMedID:17142741]

A*02:01/GILGFVFTL (Influenza A MP

Ljungman, P. et al. (2008). Influenza vaccination in hematopoietic SCT recipients. Bone Marrow Transplantation. 42: 637-641. [PubMedID: 18724396]

Mostböck, S. et al. (2007). Enhanced levels of costimulation lead to reduced effector/memory CD8+ T cell functionality. J. Immunol. 179: 3524-34. [PubMedID: 17785786]

H-2Db/ASNENMDAM (Flu NP68)

Mostböck, S. et al. (2008). IL-2/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8+ T cell responses and increases the ratio of effector/memory CD8+ T cells to regulatory T cells. J. Immunol. 180: 5118-5129. [PubMedID: 18354238]

H-2Db/ASNENMDAM (Flu NP68)

Obermann, S. et al. (2007). Peptide b-microglobulin-major histocompatibility complex expressing cells are potent antigen-presenting cells that can generate specific T cells. Immunology 122: 90-7. [PubMedID: 17472719]

A*02:01/GILGFVFTL (Flu MI)

A*02:01/SLLMWITQV (NY-ESO-1)

Price, GE. et al. (2009). Vaccination focusing immunity of conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses. Vaccine. 27: 6512-6521 [PubMedID: 19729082]

H-2Kd/TYQRTRALV (Influenza A NP)

Ross, TM. et al. A trivalent virus-like particle vaccine elicits protective immune responses against seasonal influenza strains in mice and ferrets. PLos One. 4: e6032. [PubMedID: 19554101]

H-2Kd/IYSTVASSL (Influenza NP)

H-2Kd/TYQRTRALV (Infleunza NP)

Sawai, T. et al. (2008). Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin. Immunology 124: 155-165. [PubMedID: 18205793]

H-2Db/ASNENMDAM (Flu NP)

Saxena, A. et al. (2008). Cutting Edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. J. Immunol. 181: 1617-1621 [PubMedID: 18641296]

H-2Kd/IYSTVASSL (Influenza A HA)

Singh, N. et al. (2008). Bovine adenoviral vector-based H5N1 influenza vaccine overcomes exceptionally high levels of pre-existing immunity against human adenovirus. Mol. Ther. 16: 965-71. [PubMedID:18301400]

H-2Kd/IYSTVASSL (Influenza HA)

Suneetha, PV. et al. (2009). Effect of peptide pools on effector functions of antigen-specific CD8+ T cells. J Immunol. Methods 342: 33-48. [PubMedID: 19135447]

A*02:01/GILGFVFTL (Influenza MP)

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/CINGVCWTV (HCV NS3)

Takeuchi, A. et al. (2009). CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. J. Immunol. 183: 4220-4228 [PubMedID: 19752223]

H-2Db/ASNENMDAM (Influenza NP)

Vogt, A. et al. (2008). Transcutaneous anti-influenza vaccination promotes both CD4 and CD8 T cell immune responses in humans. J. Immunol. 180: 1482-9. [PubMedID:18209043]

A*02:01/GILGFVFTL (Influenza MP)

Waeckerle-Men, Y. et al. (2005). Dendritic cells generated from patients with androgen independent prostate cancer are not impaired in migration and T cell stimulation. The Prostate 64: 323-331. [PubMedID:15754347

A*02:01/GILGFVFTL (Influenza A MP)

Westendorf, A.M. et al. (2006). Autoimmune-mediated intestinal inflammation-impact and regulation of antigen-specific CD8+ T cells. Gastroenterology 131: 510-524. [PubMedID: 16890605]

H-2Kd/IYSTVASSL (Influenza A HA)

Xie, D. and McElhaney, J. (2007). Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes. Mech Ageing Dev. 128: 392-400. [PubMedID:17570460]

A*02:01/GILGFVFTL (Flu MP)

Zhang, X. et al. (2008). Treatment of pulmonary metastatic tumors in mice using lentiviral vector-engineered stem cells. Cancer Gene Ther. 15: 73-84. [PubMedID: 18084244]

H-2Kd/IYSTVASSL (Flu HA)

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Lymphocytic Choriomeningitis Virus (LCMV)

Fousteri, G. et al. (2009). CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes. J. Autoimmunity. 32: 70-77 [PubMedID: 19162441]

H-2Db/KAVYNFATC (LCMV gp33)

H-2Db/FQPQNGQFI (LCMV NP)

Pardo, J. et al. (2008). Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 15: 567-579. [PubMedID: 18064039]

H-2Db/KAVYNFATC (LMCV gp33)

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Listeria

Bahjat, K. et al. (2009). Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria. PLos Pathogens. 5: e1000568 [PubMedID:19730694]

H-2Kb/SIINFEKL (Ovalbumin)

Gurung, P. et al. (2009). Chronic ethanol induces inhibition of antigen-specific CD8+ but not CD4+ immunodominant T cell responses following Listeria monocytogenes inoculation. J. Leukoc. Biol.85: 34-43 [PubMedID: 18820175]

H-2Kd/GYKDGNEYI (Listeriolysin O)

Husseiny, MI. and Hensel, M. (2009) Evaluation of Salmonella live vaccines with chromosomal expression cassettes for translocated fusion proteins. Vaccine 27: 3780-3787 [PubMedID: 19464562]

H-2Kd/GYKDGNEYI (Listeriolysin O)

Seo, S.K. et al. (2007). Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection. Immunology 123: 90-9. [PubMedID: 17971153]

H-2Kd (Listeriolysin O)

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Malaria

Rodriguez, A. et al. (2008). Impact of recombinant Ad35 priming versus boosting of a Plasmodium falciparum protein: characterization of T- and B-cell responses to the liver stage antigen 1 (LSA-1). Infect Immun. 76: 1709-1718. [PubMedID: 18212075]

H-2Kd/YYIPHQSSL (LSA Plasmodium falciparum)

Tartz, S. et al. (2006). Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria. Infect. Immun. 74: 2277-2285. [PubMedID: 16552058]

H-2Kd/SYIPSAEKI (Plasmodium berghei CSP)

Tartz, S. et al. (2008). Complete protection against P.berghei malaria upon heterologous prime/boost immunization against circumsporozite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid. Vaccine. 26: 5935-5943. [PubMedID: 18804138]

H-2Kd/SYIPSAEKI (CSP)

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Minor Histocompatibility Antigen (MiHAg)

Baldwin, T. et al. (2005). The timing of TCRa expression critically influences T cell development and selection. J Exp Med. 202: 111-121. [PubMedID: 15998791

H-2Db/KCSRNRQYL (miHAg smcy)

D'Asaro, M. et al. (2006). Increase of CCR7(-) CD45RA(+) CD8 T cells (T(EMRA)) in chronic graft-versus-host disease. Leukemia 20: 545-547. [PubMedID:16408100]

A*02:01/FIDSYICQV (miHAg SMCY)

Fan, Y. et al. (2009). Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J. 28: 2812-2824. [PubMedID: 19680229]

H-2Db/WMHHNMDLI (miHAg UTY)

Eiz-Vesper, B. et al. (2006). Tetanus toxoid provides efficient T-cell help for the induction of HA-1(H) cytotoxic T cells. Transfusion 46: 1210-1220. [PubMedID:16836569]

Hu, Q. et al. (2009). Bim-mediated Apoptosis in not necessary for thymic negative selection to ubiquitous self-antigens. J. Immunol. 183: 7761-7767. [PubMedID: 19933852]

H-2Db/KCSRNRQYL (miAg SMCY)

Kwun, J. et al. (2007) Altered distribution of H60 minor H Antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- Mouse Recipients. J Immunol. 179: 8016-8025. [PubMedID: 18056341]

H-2Kb/SGIVYIHL (H4b)

H-2Kb/KAPDNRDTL (H7b)

H-2Kb/SSVIGVWYL (H13b)

H-2Kb/ILENFPRL (H28)

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Mycobacterium Tuberculosis

Begum, D. et al. (2009). Accelerated induction of mycobacterial antigen-specific CD8+ T cells in the Mycobacterium tuberculosis-infected lung by subcutaneous vaccination with Mycobacterium bovis bacille Calmette-Guerin. Immunology. 128: 556-563. [PubMedID: 19930045]

H-2Db/GAPINSATAM (Mycobacterium Tuberculosis 32a)

Billeskov, R. et al. (2007). Induction of CD8 T Cells against a novel epitope in TB10.4: Correlation with mycobacterial virulence and the presence of a functional region of Difference-1. J. Immunol. 179: 3973-3981 [[PubMedID:17785835]

H-2Kb/IMYNYPAM (Mycobacterium tuberculosis M.tb 10.4)

Caccamo, N. et al. (2006). Phenotypical and functional analysis of memory and effector human CD8 T cells specific for mycobacterial antigens. J. Immunol. 177: 1780-1785. [PubMedID: 16849488]

A*02:01/GLPVEYLQV (Mycobacterium bovis antigen 85-A)

Hoang, TTKT. et al. (2009). Distinct differences in the expansion and phenotype of TB10-4 specific CD8 and CD4 T cells after infection with Mycobacterium tuberculosis. PLoS ONE. 4: e5928 [PubMedID: 19529765]

H-2Kb/IMYNYPAM (Mycobacterium tuberculosis M.tb 10.4)

Jaron, B. et al. (2008). Effect of attenuation of Treg during BCG immunization on anti-mycobacterial Th1 responses and protection against Mycobacterium tuberculosis. PLoS ONE 3: e2833 [PubMedID: 18665224]

H-2Kd/VYAGAMSGL (TB10.3/4:208-28)

Radosevic, K. et al. (2007). Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains (H-2d vs. H-2b): CD4 and CD8 T-cell epitope mapping and role of gamma interferon. Infect. Immun. 75: 4105-4115. [[PubMedID:17526747]

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Respiratory Syncytial Virus (RSV)

Beyer, M. et al.(2005). The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo. Respir Res. 6: 70-80. [PubMedID:16011799]

H-2Kd/SYIGSINNI (RSV M2)

Cyr, SL. et al. (2007). Intranasal proteosome-based respiratory syncytial virus (RSV) vaccines protect BALB/c mice against challenge without eosinophilia or enhanced pathology. Vaccine. 25: 5378-5389. [PubMedID: 17561317]

H-2Kd/KYKNAVTEL (RSV A strain F protein)

DiNapoli, JM. et al. (2008). Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection. Virology Journal. 5: 105 [PubMedID: 18816384]

H-2Kd/TYQRTRALV (Influenza NP)

H-2Kd/SYIGSINNI (RSV M2)

Kochenderfer, J.N. et al. (2006). Synergism between CpG-Containing Oligodeoxynucleotides and IL-2 Causes Dramatic Enhancement of Vaccine-Elicited CD8+ T Cell Responses. J. Immunol. 177: 8860-8873. [PubMedID:17142789]

H-2Kd/SYIGSINNI (RSV M2)

Pribul, P. et al. (2008). Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development. J. Virol. 82: 4441-4448. [PubMedID:18287232]

H-2Kd/SYIGSINNI (RSV M2)

Smit, J.J. et al. (2008). The balance between plasmacytoid DC versus conventional DC determines pulmonary immunity to virus infections. PLoS ONE 3(3): e1720. [PubMedID:18320041

H-2Kd/SYIGSINNI (RSV M2)

Trypanosoma Cruzi

de Alencar, BCG. et al. (2009). Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination. Infection & Immunity. 77: 4383-4395. [PubMedID: 1965871]

H-2Kb/VNHRFTLV (Trypanosoma cruzi ASP-2)

Tzelepis, F. et al. (2008) Infection with Trypanosoma cruzi restricts the repertoire of parasite-specific CD8+ T cells leading to immunodominance. J Immunol. 180: 1737-1748. [PubMedID: 18209071]

H-2Kb/VNHRFTLV (Trypanosoma cruzi ASP-2)

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Vaccinia Virus

Freyschmidt, E-J. et al. (2007). Skin inflammation in RelB(-/-) mice leads to defective immunity and impaired clearance of vaccinia virus. J. Allergy Clin. Immunol. 119:671-679. [PubMedID: 17336617]

Laouar, A. et al. (2008) Concurrent generation of effector and central memory CD8 T cells during vaccinia virus infection. PLoS one. 3: e4089 [PubMedID: 19116651]

H-2Kb/TSYKFESV (vaccinia virus B8R)

Luckashenak, N. et al. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells control CD8+ T cell tolerance in vivo. Immunity. 28: 521-532. [PubMedID: 18387832]

H-2Kb/SIINFEKL (Ovalbumin)

H-2Kb/SSIEFARL (HSV-gpB)

H-2Kb/TSYKFESV (vaccinia virus B8R)

Oyoshi, MK. et al. (2009). Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. PNAS 106: 14954-14959. [PubMedID: 19706451]

H-2Kb/TSYKFESV (vaccibia virus B8R)

Rosenthal, R. et al. (2009). Differential responsiveness to IL-2, IL-7 and Il-15 common receptor g chain cytokines by antigen-specific peripheral blood naive or memory cytotoxic CD8+ T cells from healthy donors and melanoma patients. J Immunother. 32: 252-261. [PubMedID: 19242375]

A*02:01/NLVPMVATV (CMV pp65)

A*02:01/GLCTLVAML (EBV BMLF-1)

A*02:01/ELAGIGILTV (MelanA/MART-1)

A*02:01/SLSAYIIRV (Vaccinia Virus H3L)

A*02:01/KVDDTFYYV (Vaccinia Virus C7L)

Samuelsson, C. et al. (2008). Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection. J. Clin. Invest. 118: 1776-1784 [PubMedID: 18398511]

H-2Kb/TSYKFESV (modified vaccinia virus ankara)

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Other

Baschuk, N. et al. (2007). Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice. Cancer Immunol. Immunother. 56: 1625-36. [PubMedID: 17431618]

H-2Kb/VVYDFLKL (SV40 tag)

Carr, D.J.J. et al. (2006). The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection. Immunology 118: 520-526. [PubMedID:16895559]

H-2Kb/SSIEFARL (HSV-1 gp B)

Claassen, EA. et al. (2007). Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity. Virology. 368: 17-25. [PubMedID: 17632195]

H-2Kd/CYLTDRARI (PVM G)

Claassen, E.A. (2005). Activation and inactivation of antiviral CD8 T cell responses during murine pneumovirus infection. J. Immunol. 175: 6597-6604. [PubMedID:16272314]

H-2Kd/CYLTDRARI (PVM G)

de Beukelaar, JW. et al. (2007) No evidence for circulating HuD-specific CD8+ T cells in patients with paraneoplastic neurological syndromes and Hu antibodies. Cancer Immunol Immunother.56: 1501-1506. [PubMedID: 17597332]

A*01:01/ELEQLFSQY (HuD-SCLC)

A*01:01/RLDNLLNMAY (HuD-SCLC)

A*02:01/SLGYGFVNYI (HuD-SCLC)

A*02:01/NLLNMAYGV (HuD-SCLC)

A*02:01/QLFGPFGAV (HuD-SCLC)

A*02:01/RLGDRVLQV (HuD-SCLC)

A*02:01/QYGRIITSRI (HuD-SCLC)

Dudek, T. et al. (2008) Disruption of the UL41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes. Virology. 372: 165-175 [PubMedID: 18006033]

H-2Kb/SSIEFARL (HSV gpB)

Duplan, V. et al. (2007). Tracking antigen-specific CD8+ T cells in the rat using MHC class I multimers. J. Immunol. Methods 320: 30-39. [PubMedID: 17223126]

First custom Pentamer synthesized for rat MHC

Fallarino, F. et al. (2006). The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor z chain and induce a regulatory phenotype in naive T cells. J. Immunol. 176: 6752-6761. [PubMedID:16709834]

Isa, A. et al. (2005). Prolonged activation of virus-specific CD8+ T cells after acute B19 infection. PLoS Med. 2: e343. (Epub) [PubMedID: 16253012]

Jakel, S. et al. (2009). Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis. Am. J. Pathol. 175: 510-518. [PubMedID:19590042]

H-2Db/FRHNNVTLM (VP2)

H-2Kb/TLPAFSTL (P3D)

Liu, K. et al. (2006). CTL adoptive immunotherapy concurrently mediates tumor regression and tumor escape. J. Immunol. 176: 3374-3382. [PubMedID:[16517705]

H-2Ld/SPSYVYHQF (MuLV env gp70)

Luckashenak, N. et al. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells control CD8+ T cell tolerance in vivo. Immunity. 28: 521-532.[PubMedID: 18387832]

H-2Kb/SIINFEKL (Ovalbumin)

H-2Kb/SSIEFARL (HSV-gpB)

H-2Kb/TSYKFESV (vaccinia virus B8R)

Matter, M. et al. (2006). Elimination of chronic viral infection by blocking CD27 signaling. J. Exp. Med. 203: 2145-2155. [PubMedID: 16923852]

Mazzarella, G. et al (2008). Gliadin activates HLA class-1-restricted CD8+ T cells in celiac disease intestinal mucosa and induces enterocyte apoptosis. Gastroenterology. 134: 1017-1027. [PubMedID: 18395083]

A*02:01/QLIPCMDVVL (Gliadin pA2)

A*02:01/SLYNTVATL (HIV-1 gag17)

Panoskaltsis-Mortari, A. et al. (2008). In situ identification of allospecific B cells using pentamers. Blood 111: 3904-5. [PubMedID:18362221

H-2Kd/GYKDGNEYI (Listeriolysin O)

H-2Kd/RRLGRTLLL (Polyoma virus middle T protein)

Svensson, A. et al. (2005). Neurokinin 1 receptor signaling affects the local innate immune defense against genital Herpes virus infection. J. Immunol. 175: 6802-6811. [PubMedID:16272337]

H-2Kb/SSIEFARL (HSV-1 gp B<)

Svensson, A. et al. (2005). Protective immunity to genital herpes simplex virus type 2 infection is mediated by T-bet. J. Immunol. 174: 6266-6273. [PubMedID:15879125]

H-2Kb/SSIEFARL (HSV-1 gp B)

Takamura, S. et al. (2010) Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+ T Cells by Rapid Induction of Multiple Inhibitory Receptors.  Journal of Immunology 184: 4696-4707 [PubMedID:20351188]

H-2Db/CCLCLTVFL (F-MuLV gag 75-83)

Verschelde, C. et al. (2006). Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection. Cell Death Differ. 13: 1213-1221. [PubMedID:16294210]

Wickham, S. et al. (2005). Chemokine receptor deficiency is associated with increased chemokine expression in the peripheral and central nervous systems and increased resistance to herpetic encephalitis. J. NeuroImmunol. 162: 51-59. [PubMedID:15833359]

H-2Kb/SSIEFARL (HSV-1 gp B)

Yang, W. et al. (2007). Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML). Int. Immunol. 19: 1083-1093 [PubMedID:17660502]

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Model Antigen

Abdel-Motel, UM. et al. (2009). Mechanism for increased immunogenicity of vaccines that form in vivo immune complexes with the natural anti-Gal antibody. Vaccine. 27: 3072-3082. [PubMedID: 19428921]

H-2Kb/SIINFEKL (Ovalbumin)

Annoni, A. et al. (2009). In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance. Blood. 114: 5152-5161. [PubMedID: 19794140]

H-2Kd/HYLSTQSAL (eGFP)

Arnaboldi, PM. et al. (2009). Suppression of Th1 and Th17, but not Th2, responses in a CD8+ T cell-mediated model of oral tolerance. Mucosal Immunology. 2: 427-438. [PubMedID: 19571798]

H-2Kb/SIINFEKL (Ovalbumin)

Bahjat, K.S. et al. (2006). Cytosolic Entry Controls CD8 + T cell Potency During Bacterial Infection. Infect. Immun. 74: 6387-6397. [PubMedID: 16954391]

H-2Kb/SIINFEKL (Ovalbumin)

Bahjat, K. et al. (2009). Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria. PLos Pathogens. 5: e1000568 [PubMedID:19730694]

H-2Kb/SIINFEKL (Ovalbumin)

Bellone, M. et al. (2010). iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells. PLoS ONE. 5: e8646. [PubMedID: 20072624]

H-2Kb/SIINFEKL (Ovalbumin)

Binder, R.et al. (2005). Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells. Nature Immunol. 6: 593-599. [PubMedID: 15864309]

H-2Kb/SIINFEKL (Ovalbumin)

Bouma, G. et al. (2007). Impaired T cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood. 110: 4278-84 [PubMedID:17673604]

H-2Kb/SIINFEKL (Ovalbumin)

Bourquin, C. et al. (2008). Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity. J. Immunol. 181: 2990-2998 [PubMedID: 18713969]

H-2Kb/SIINFEKL (Ovalbumin)

Bourquin, C. et al. (2007). Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T cell and IgG2a response. Blood 109: 2953-2960. [PubMedID:17132722]

H-2Kb/SIINFEKL (Ovalbumin<)

Connolly, MK. et al. (2009). In liver fibrosis, dendiritc cells govern hepatic inflammation in mice via TNF-a. J. Clin. Invest. 119: 3213-3225 [PubMedID:19855130]

H-2Kb/SIINFEKL (Ovalbumin)

Degl'Innocenti, E. et al. (2008). Peripheral T-cell tolerance associated with prostate cancer is independent from CD4+/CD25+ regulatory T cells. Cancer Res. 68: 292-300. [PubMedID: 18172322]

H-2Kb/VVYDFLKL (SV40 T antigen)

Diebold, SS. et al. (2008). Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines. Gene Therapy. 16: 359-366 [PubMedID: 19052633]

H-2Kb/SIINFEKL (Ovalbumin)

Ding, C. et al. (2008) Targeting of antigens to B cells augments antigen-specific T cell responses and breaks immune tolerance to tumor-associated MUC1. Blood 112: 2817-2825 [PubMedID: 18669871]

H-2Kb/SIINFEKL (Ovalbumin)

Ga, M. et al. (2007). Single CX3CL1-Ig DNA administration enhances T cell priming in vivo. Vaccine 25: 4554-63. [PubMedID:[17493713]

H-2Kb/SIINFEKL (Ovalbumin)

Ghosh, A. et al. (2008).Cytotoxic T cells reactive to an immunodominant leukemia-associated antigen can be specifically primed and expanded by combining a specific priming step with nonspecific large-scale expansion. J Immunother. 31: 121-131. [PubMedID:18481382]

H-2Kb/SIINFEKL (Ovalbumin)

Grolleau-Julius, A. et al. (2008). Impaired dendritic cell function in aging leads to defective antitumor immunity. Cancer Res 68: 6341-6349 [PubMedID: 18676859]

H-2Kb/SIINFEKL (Ovalbumin)

Gutermuth, J. et al. (2009). Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V{alpha}2 down-regulation. J. Immunol. 183: 3130-3138. [PubMedID: 19675167]

H-2Kb/SIINFEKL (Ovalbumin)

Harms, JS. et al. (2009) Evaluation of recombinant invasive, non-pathogenic Eschericia coli as a vaccine vector against the intracellular pathogen, Brucella. Journal of Immune Based Therapies and Vaccines. 7: 1 [PubMedID: 19126207]

H-2Kd/HYLSTQSAL (eGFP)

Hamasaki, T. et al. (2010).  Modulation of Gene Expression Related to Toll-Like Receptor Signaling in Dendritic Cells by Poly(g-Glutamic Acid) Nanoparticles.  Clinical and Vaccine Immunology 17: 748-276 [PubMedID: 20219877]

H-2Kb/SIINFEKL (Ovalbumin)

Kim, YH. et al. (2008) Combination therapy with cisplatin and anti-4-1BB synergisic anticancer effects and amelioration of cisplatin-induced nephrotoxicity. Cancer Res. 68: 7264-7269 [PubMedID: 18794112]

H-2Kb/SIINFEKL (Ovalbumin)

Kim, YH. et al. (2009) Mechanisms involved in synergisitic anticancer effects of anti-4-1BB and cyclophosphamide therapy. Mol. Cancer Ther. 8: 469-478. [PubMedID:19190115]

H-2Kb/SIINFEKL (ovalbumin)

Leggat, JA. et al. (2008). Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization. J. Allergy Clin. Immunol. 122: 1014-1021. [PubMedID: 18804851]

H-2Kb/SIINFEKL (Ovalbumin)

Luci, C. et al. (2006). Dendritic cell-mediated induction of mucosal cytotoxic responses following intravaginal immunization with the non-toxic B subunit of Cholera toxin. J. Immunol. 176: 2749-2757. [[PubMedID:16493030]

H-2Kb/SIINFEKL (Ovalbumin)

Luckashenak, N. et al. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells control CD8+ T cell tolerance in vivo. Immunity. 28: 521-532. [PubMedID: 18387832]

H-2Kb/SIINFEKL (Ovalbumin)

H-2Kb/SSIEFARL (HSV-gpB)

H-2Kb/TSYKFESV (vaccinia virus B8R)

Martin-Orozco, et al. (2006). Programmed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens. J. Immunol. 177: 8291-8295. [PubMedID:17142723]

H-2Kb/SIINFEKL (Ovalbumin)

Mascolo, D. et al. (2007). Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response. FEMS Immunol. Med. Microbiol. 50: 59-66. [PubMedID: 17391361]

H-2Kb/SIINFEKL (Ovalbumin)

H-2Kb/SSYSYSSL

McBurney, WT. et al. (2008). In vivo activity of cationic immune stimulating complexes (PLUSCOMs). Vaccine. 26: 4549-4556 [PubMedID: 18585421]

H-2Kb/SIINFEKL (Ovalbumin)

McIlroy, D. et al. (2009). DNA/Amphiphilic block copolymer nanospheres promote low-dose DNA vaccination. Mol. Ther. 17: 1473-1481 [PubMedID: 19417740]

H-2Kb/SIINFEKL (Ovalbumin)

Mouries, J. et al. (2008). Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation. Blood. 112: 3713-3722 [PubMedID: 18698004]

H-2Kb/SIINFEKL (Ovalbumin)

Nitcheu-Tefit, J. et al. (2007). Listeriolysin O expressed in a bacterial vaccine suppresses CD4+ CD25high regulatory T cell function in vivo. J. Immunol. 179: 1532-1541. [PubMedID:17641019]

H-2Kb/SIINFEKL (Ovalbumin)

Noble, A. et al. (2006). Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage. Blood 107: 4475-4483. [PubMedID:16467201]

H-2Kb/SIINFEKL (Ovalbumin)

Ohnmacht, C. et al. (2009). Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J. Exp. Med. 206: 549-559 [PubMedID: 19237601]

H-2Kb/SIINFEKL (Ovalbumin)

Pascual, DW. et al. (2008). The absence of lymphoid CD8+ dendritic cell maturation in L-selectin-/- respiratory compartment attenuates antiviral immunity J Immunol. 181: 1345-1356 [PubMedID: 18606689]

H-2Kb/SIINFEKL (Ovalbumin)

Puaux, A-L et al. (2006) A very rapid and simple assay based on trogocytosis to detect and measure specific T and B cell reactivity by flow cytometry. Eur. J. Immunol. 36: 779-788. [PubMedID:16482513]

H-2Kb/SIINFEKL (Ovalbumin)

H-2Db/KAVYNFATC (LCMV GP1)

Ren, Y. et al. (2006). OVA-specific CD8+ T cells do not express granzyme B during anterior chamber associated immune deviation. Graefes Arch. Clin. Exp. Ophthalmol. 244: 1315-1321. [PubMedID:16538449]

H-2Kb/SIINFEKL (Ovalbumin)

Rowe, HM. et al. (2009). Expression of vFLIP in a lentiviral vaccine vector activates NF-kB matures dendritic cells and increases CD8+ T-cell responses. J. Virol. 83: 1555-1562 [PubMedID: 19036811]

H-2Kb/SIINFEKL (Ovalbumin)

Russo, V. et al. (2007). Lymphocytes genetically modified to express tumor antigens target DCs in vivo and induce antitumor immunity. J. Clin. Invest. 117: 3087-96. [PubMedID:17885685]

H-2Kb/SIINFEKL (Ovalbumin)

Sakowicz-Burkiewicz, M. et al. (2008) Protein kinase C-{theta} critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis. J. Immunol. 180: 5601-5612. [PubMedID:18390745]

H-2Kb/SIINFEKL (Ovalbumin)

H-2Db/KAVYNFATC (LMCV gp33)

Saveanu, L. et al. (2009). IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science. 325: 213-217. [PubMedID:19498108]

H-2Kb/SIINFEKL (Ovalbumin)

Steitz, J. et al. (2006). Comparison of recombinant adenovirus and synthetic peptide for DC-based melanoma vaccination. Cancer Gene Ther. 13: 318-325. [PubMedID:16151477]

H-2Kb/SIINFEKL (Ovalbumin)

Stoitzner, P. et al. (2008). Tumor immunotherapy by epicutaneous immunization requires langerhans cells. J. Immunol. 180: 1991-8. [PubMedID:18209098]

H-2Kb/SIINFEKL (ovalbumin)

Terabe, M. et al. (2008). IL-15 expands unconventional CD8aa NK1.1+T cells but not Va14Ja18+ NKT cells. J Immunol. 180: 7276-7286. [PubMedID:18490727

H-2Kb/SIINFEKL (Ovalbumin)

Thompson, JM. et al. (2008). Alphavirus replicon particlaes acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. Vaccine. 26: 4267-4275 [PubMedID: 18585421]

H-2Kb/SIINFEKL (Ovalbumin)

Tomihara, K. et al. (2010).  Antigen-Specific Immunity and Cross-Priming by Epithelial Ovarian Carcinoma-Induced CD11b+Gr-1+ Cells [PubMedID: 20427766]

H-2Kb/SIINFEKL (Ovalbumin)

Tripp, CH. et al. (2009). Glycolipids injected into the skin are presented to NKT cells in the draining lymph node independently of migratory skin dendritic cells. J. Immunol. 182: 7644-7654. [PubMedID:19494288]

H-2Kb/SIINFEKL (Ovalbumin)

Uto, T. et al. (2009). Improvement of adaptive immunity by antigen-carrying biodegradable nanoparticles. Biochem. Biophys. Res. Comm. 379:600-604 [PubMedID: 19121627]

H-2Kb/SIINFEKL (Ovalbumin)

Wells, JW. et al (2008). Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J Immunol. 181: 3422-3431 [PubMedID:18714014]

H-2Kb/SIINFEKL (Ovalbumin)

H-2Kb/SVYDFFVWL (TRP-2)

Wells, JW. et al. (2009). Suppression of allergic airway inflammation and IgE responses by a class I restricted allergen peptide vaccine. Mucosal Immunology 2: 54-62 [PubMedID: 19079334]

H-2Kb/SIINFEKL (Ovalbumin)

Wysocki, PJ. et al. 2006). Captopril, an Angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice. Clin. Cancer Res. 12: 4095-4102. [PubMedID:16818710]

H-2Kd/HYLSTQSAL (eGFP)

Yasuda, T. et al. (2007). Superior anti-tumor protection and therapeutic efficacy of vaccination with allogenic and semiallogenic dendritic cell/tumor cell fusion hybrids for murine colon adenocarcinoma. Cancer Immunol. Immunother. 56: 1025-36. [PubMedID:17131118]

H-2Ld/SPSYVYHQF (muLV envgp70)

H-2Ld/TPHPARIGL (E. Coli b-galactosidase)

Zaini, J. et al. (2007). OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. J. Clin. Invest. 117: 3330-8. PubMedID: 17975668]

H-2Kb/SIINFEKL (Ovalbumin)

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