An Integrated Approach to Managing Immunogenicity Risk and Optimum Protein Design

Immunogenicity is one of the most complex issues to address in drug design and development. I will provide an overview of the best tools for immunogenicity risk mitigation, including Mass Spectrometry antigen presentation assays, Dendritic cell-T cell assays to measure responses to fully formulated biologics, HLA-peptide Binding Assays, and naïve T cell Proliferation Assays to characterize individual epitopes. I will also discuss how the potential risk of first infusion reactions can be mitigated using whole-blood cytokine release assays.
Jeremy Fry gained his DPhil. from the University of Oxford working with Prof. Kathryn Wood and Prof. Peter Morris developing gene therapy strategies to induce immunological tolerance in transplant recipients. Jeremy joined ProImmune in the R&D team to generate a new class of MHC multimer staining reagents. Since 2002, as ProImmune’s Director of Sales, he has led the sales team in a growing business, focusing on technologies that radically improve our understanding of immune responses.