ProT2® MHC Class II Tetramers

Dr. ShuTing Han (National Cancer Centre Singapore, Singapore)
“My experience working with ProImmune has been exceptionally positive. What truly differentiates them is their expert guidance in designing peptides for custom Class II tetramer synthesis – a level of scientific partnership I haven’t found with other vendors, including core facilities like those at NIH. While other providers simply fulfil requests with numerous caveats and long wait times, ProImmune’s team actively collaborates with researchers throughout the entire process. Their ability to deliver custom Class II tetramers in a timely manner, combined with their hands-on scientific support.”

Dr. Mitchell Zheng (University of Melbourne, Australia)
“At the forefront of vaccine development, our research focuses on decoding the mechanisms of murine and human CD4+ T follicular helper (Tfh) cells. These investigations demand the highest quality reagents – a need consistently met by ProImmune. For many years, we’ve relied on ProImmune’s comprehensive MHC class II catalog and custom monomers, including pre-conjugated variants, with our lab ordering a diverse range of specialized reagents. This sustained partnership, expertly facilitated by ProImmune Asia-Pacific representative, stands as clear evidence of our trust in ProImmune’s reliability and technical excellence.

A recent challenge in mapping novel CD4+ T cell epitopes required custom tetramers capable of tracking antigen-specific cells in their native state. While other vendors fell short, ProImmune delivered where others couldn’t. Their successful development of this critical reagent has opened new avenues in our research program. Working with the ProImmune Asia-Pacific representative has been exceptional. Their specialist combines deep immunological expertise with remarkable responsiveness, enabling rapid procurement of precisely tailored reagents. What truly distinguishes ProImmune is their scientific partnership approach. When theoretical models suggested a particular monomer synthesis would fail, they carefully evaluated our empirical staining data and proceeded with production. This data-driven, collaborative mindset has repeatedly accelerated our discoveries, making ProImmune not just a supplier, but a true research enabler.“