T cell responses in obese & non-obese dengue patients with varying disease severity

Prof. Malavige explores the link between obesity, metabolic diseases, and severe dengue infection. Highlighting data from Sri Lanka and global studies, they show that obese and diabetic patients are at higher risk of hospitalization, severe disease, and complications like plasma leakage. The presentation also delves into T cell responses, immune dysfunction, and the role of adipokines in disease severity, emphasizing how obesity impacts immune regulation. Finally, key findings on T cell activation, tissue homing, and memory responses shed light on the immunological mechanisms behind severe dengue in adults.