Protein deimmunization by T cell epitope deletion

Professor Yoonjoo Choi is based at Chonnam National University Medical School in Korea. His work focuses on the development and application of computational methods for biological and immunological problems, in the context of protein sequence/structure/function studies. His primary focus has been structure-based computational modeling and computationally-driven engineering of the immune response to foreign proteins, in the contexts of both desired responses in infection/vaccination and undesired responses to therapeutics. Of particular relevance to what he’ll be describing today, he used to work in close collaboration with former Professors Karl Griswold and Chris Bailey-Kellogg at Dartmouth to reengineer therapeutic proteins. Today he will be describing their protein deimmunization strategy by T-cell epitope deletion.