Immune Divergence Between Vaccine-Associated and Conventional Myocarditis

Prof. Lee explores myocarditis, focusing on both conventional and mRNA vaccine-associated cases. Using tissue-confirmed patients and advanced single-cell and spatial omics techniques, the study identifies a unique population of CCL2-positive monocytes linked to inflammation and emergent myelopoiesis. The research highlights differences between infection- and vaccine-associated myocarditis, including distinct interferon and TNF/NFκB signatures, and suggests potential mechanisms involving prolonged spike protein exposure. Findings may inform strategies for vaccination intervals and immunosuppressive treatments in severe myocarditis cases.