Antibody repertoire monitoring: application to anti-drug antibodies

Although most Anti-Drug Antibodies (ADA’s) are innocuous, some low abundance or low frequency ADA’s may pose a significant clinical risk which is difficult to evaluate at the serum level. Trellis’ established technology platform for efficient cloning of rare B-cells enables deconvolution of serum into its component monoclonal ADA’s. Our computational B cell epitope prediction technology accelerates cloning ADA’s against all epitopes on the protein when a high quality structure is available. The combined computational and empirical technology provides a rational route to immunological silencing of potentially problematic epitopes.