CD3 downregulation identifies high-avidity human CD8 T cells

Genevieve Clutton is a Research Associate at the University of North Carolina at Chapel Hill. She received her doctorate from the University of Oxford, where she studied the role of T cell-derived IL-10 in HIV-1 pathogenesis. In 2014, she moved to Chapel Hill, initially joining the University’s HIV cure program and elucidating the effects of putative HIV latency-reversing agents on HIV-specific T cells. Subsequently, she broadened her focus to study T cell function and metabolism across a range of human diseases. Her research focuses on cell-intrinsic factors that contribute to T cell dysfunction in chronic viral infection and cancer.