Immunity Research citing the use of ProImmune Pentamers

Have you published a paper citing the use of ProImmune’s products or services? If so, please send us a reprint as a PDF by e-mail to enquiries@www.proimmune.com. We will send you a bottle of Champagne to celebrate with! (Limited to 1 bottle per publication).

 

Allergy	Autoimmunity
Minor Histocompatibility Antigen (miHAg)	Other

Model Antigen

 

Allergy

Woodfolk J.A.  (2007) T-cell responses to allergens. Journal of Allergy and Clinical Immunology 119:280[PubMedID:17291848]

 

Autoimmunity

Ankathatti Munegowda et al  (2011) A Distinct Role of CD4(+) Th17- and Th17-Stimulated CD8(+) CTL in the Pathogenesis of Type 1 Diabetes and Experimental Autoimmune Encephalomyelitis. J Clin Immunol.[PubMedID: 21674137]

Arce F. et al  (2011) Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis. Arthritis Rheum. 63(1):84-95 [PubMedID:20967853]

Crampton et al (2012) Ifih1 Gene Dose Effect Reveals MDA5-Mediated Chronic Type I IFN Gene Signature, Viral Resistance, and Accelerated Autoimmunity.  Journal of Immunology 188:1451 [PubMedID:22205024]

Engkilde, K. et al (2011) Prevention of type 1 diabetes by inducing subclinical dermatitis on a small area Diabetes and Metabolism Research and Reviews. 27: 954

Fierabracci, A. (2011) The potential of multimer technologies in type 1 diabetes prediction strategies. Diabetes and Metabolism Research and Reviews. 27: 216-229 [PubMedID: 21309048]

Freed et al (2011) Association of the HLA–DRB1 epitope LA67, 74 with rheumatoid arthritis and citrullinated vimentin binding. Arthritis and Rheumatism 63:3733 [PubMedID:22094856]

Giuliani et al (2009) Detection of GAD65 Autoreactive T-Cells by HLA Class I Tetramers in Type 1 Diabetic Patients. Journal of Biomedicine and Biotechnology 2009:576219 [PubMedID:20029631]

Ha et al (2010) Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity. Journal of Clinical Investigation 120:4273 [PubMedID:21084750]

Ohnmacht, C. et al. (2009). Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J. Exp. Med. 206: 549-559 [PubMedID: 19237601]

H-2Kb/SIINFEKL (Ovalbumin)

Mallone, R. et al (2011) Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report—HLA Class I Tetramer Validation Initiative Diabetes and Metabolism Research and Reviews. 27: 720 [PubMedID:22069251]

Matthis et al (2012) T Cell Autoreactivity in the Transplant Milieu. American J. Transplant. 12:1674[PubMedID:22642536]

Monti, P. et al. (2008) Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J. Clin. Invest. 118: 1806-1814 [PubMedID: 18431516]

A*02:01/VMNILLQYV (GAD 65)
A*02:01/GILGFVFTL (Flu-A MP)
A*02:01/SLYNTVATL (HIV gag p17)

Monti, P. et al. (2007). Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J. Immunol. 179: 5785-92. [PubMedID: 17947651].

A*02:01/VMNILLQYV (GAD 65)
A*02:01/GILGFVFTL (Flu-A MP)
A*02:01/SLYNTVATL (HIV gag p17)

Munoz-Suano et al (2011) Regulatory T cells protect from autoimmune arthritis during pregnancy. Journal of Autoimmunity 38:J103 [PubMedID:22004905]

Van Belle et al. (2011). Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model. J. Immunol. 187: 2915 [PubMedID:21832162].

Van Belle et al (2012) Interleukin-21 Receptor-Mediated Signals Control Autoreactive T Cell Infiltration in Pancreatic Islets Immunity 36:1060 [PubMedID:22579473]

Van Belle et al (2012) NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes. Journal of Autoimmunity [PubMedID:22944096]

Weyd, H. et al (2013) Annexin A1 on the surface of early apoptotic cells suppresses CD8+ T cell immunity. PLoS One 8(4):e62449 [PubMedID:23638088]

H-2Kb/SIINFEKL (Ovalbumin 257-264)

Zierden et al (2010) Effects and Regulation of Autoreactive CD8+ T Cells in a Transgenic Mouse Model of Autoimmune Hepatitis Gastroenterology 139:975 [PubMedID:20639127]

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Minor Histocompatibility Antigen (MiHAg)

Baldwin, T. et al. (2005). The timing of TCRa expression critically influences T cell development and selection. J Exp Med. 202: 111-121. [PubMedID: 15998791

H-2Db/KCSRNRQYL (miHAg smcy)

D’Asaro, M. et al. (2006). Increase of CCR7(-) CD45RA(+) CD8 T cells (T(EMRA)) in chronic graft-versus-host disease. Leukemia 20: 545-547. [PubMedID:16408100]

A*02:01/FIDSYICQV (miHAg SMCY)

Fan, Y. et al. (2009). Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J. 28: 2812-2824. [PubMedID: 19680229]

H-2Db/WMHHNMDLI (miHAg UTY)

Flutter, B. et al. (2010). Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.Journal of Clinical Investigation[PubMedID: 20978352]

H-2Kb/LTFNYRNL(miHAg)

Eiz-Vesper, B. et al. (2006). Tetanus toxoid provides efficient T-cell help for the induction of HA-1(H) cytotoxic T cells. Transfusion 46: 1210-1220. [PubMedID:16836569]

Hu, Q. et al. (2009). Bim-mediated Apoptosis in not necessary for thymic negative selection to ubiquitous self-antigens. J. Immunol. 183: 7761-7767. [PubMedID: 19933852]

H-2Db/KCSRNRQYL (miAg SMCY)

Kwun et al (2011) Primary Vascularization of the Graft Determines the Immunodominance of Murine Minor H Antigens during Organ Transplantation. Journal of Immunology epub [PubMedID: 21900176]

Kwun, J. et al. (2007) Altered distribution of H60 minor H Antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- Mouse Recipients. J Immunol. 179: 8016-8025. [PubMedID: 18056341]

H-2Kb/SGIVYIHL (H4b)
H-2Kb/KAPDNRDTL (H7b)
H-2Kb/SSVIGVWYL (H13b)
H-2Kb/ILENFPRL (H28)

Michelini, R. et al. (2010) Concomitant Tumor and Minor Histocompatibility Antigen-Specific Immunity Initiate Rejection and Maintain Remission from Established Spontaneous Solid Tumours. Cancer Research. 70(9): 3505-14. [PubMedID: 20388780]

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Other

Allen S., et al (2011) The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus type 1.  Journal of Virology. 85: 4814 [PubMedID: 21307196]

H-2Kb/SSIEFARL (HSV-1 gp B)

Argani et al (2011) Characterization of herpes simplex virus 1 strains as platforms for the development of oncolytic viruses against liver cancer. Liver International 31: 1542 [PubMedID: 22093330] 

Attig et al (2011) A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols. Journal of Translational Medicine 9:108 [PubMedID:21745365]

Baschuk, N. et al. (2007). Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice. Cancer Immunol. Immunother. 56: 1625-36. [PubMedID: 17431618]

H-2Kb/VVYDFLKL (SV40 tag)

Bernardo et al (2011) Phenotypic and functional evaluation of CD3+CD4-CD8- T cells in human CD8 immunodeficiency. Haematologica 96:1195 [PubMedID:21546492]

Cantisan et al (2010) CD45RA expression on HCMV-specific effector memory CD8+ T cells is associated with the duration and intensity of HCMV replication after transplantation. Clinical Immunology 137:81[PubMedID:20674505]

Carr, D.J.J. et al. (2006). The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection. Immunology 118: 520-526. [PubMedID:16895559]

H-2Kb/SSIEFARL (HSV-1 gp B)

Castella et al. (2011). Immune Modulation by Zoledronic Acid in Human Myeloma: An Advantageous Cross Talk between Vg9Vδ2 T Cells, αβ CD8+ T Cells, Regulatory T Cells, and Dendritic Cells. Journal of Immunology epub. [PubMedID:21753152]

Cento et al (2011) Intratype Variation of HPV 31 and 58 in Italian women with abnormal cervical cytology. J Med Virol. 83:1752 [PubMedID:21837791]

Chang (2011) Lentiviral Vector Transduction of Dendritic Cells for Novel Vaccine Strategies. Methods in Molecular Biology 614:161 [PubMedID:20225043]

Chappert et al (2010) Antigen-specific Treg impair CD8+ T-cell priming by blocking early T-cell expansion. European Journal of Immunology 40:339 [PubMedID:19877007]

Chatterjee et al (2012) Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells  Blood [PubMedID:22791285]

Cheent et al (2013) Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. PNAS. 110:42 [PubMedID: 24082146]

E*01:01 / VMAPRTLIL (HLA-E)

Circosta et al (2009) T Cell Receptor (TCR) Gene Transfer with Lentiviral Vectors Allows Efficient Redirection of Tumor Specificity in Naive and Memory T Cells Without Prior Stimulation of Endogenous TC. Human Gene Therapy 20:1576 [PubMedID:19678763]

Claassen, EA. et al. (2007). Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity. Virology. 368: 17-25. [PubMedID: 17632195]

H-2Kd/CYLTDRARI (PVM G)

Claassen, E.A. (2005). Activation and inactivation of antiviral CD8 T cell responses during murine pneumovirus infection. J. Immunol. 175: 6597-6604. [PubMedID:16272314]

H-2Kd/CYLTDRARI (PVM G)

Davis et al (2011) Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis. Nature Reviews Immunology 11:551.  [PubMedID:21760610]

Degauque et al. (2011)  The Blood of Healthy Individuals Exhibits CD8 T Cells with a Highly Altered TCR Vb Repertoire but with an Unmodified Phenotype. PLoS One 6: e21240 [PubMedID: 21738624]

Dervovic et al. (2012) Comparative and Functional Evaluation of In Vitro Generated to Ex Vivo CD8 T Cells. J. Immunol. 189:3411 [PubMedID: 22925927]

Duewell et al. (2011) ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells. Journal of Immunology 187:55 [PubMedID: 21613613]

Dudek et al. (2011) Evidence for differences in immunologic and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa. Journal of Infectious Diseases 203:1434  [PubMedID: 21498376]

Dudek, T. et al. (2008) Disruption of the U_L41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes. Virology. 372: 165-175[PubMedID: 18006033]

H-2Kb/SSIEFARL (HSV gpB)

Duplan, V. et al. (2007). Tracking antigen-specific CD8⁺ T cells in the rat using MHC class I multimers. J. Immunol. Methods 320: 30-39. [PubMedID:17223126]

First custom Pentamer synthesized for rat MHC

Edelson et al (2010) Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. Journal of Experimental Medicine 207:823 [PubMedID:20351058]

Fallarino, F. et al. (2006). The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor z chain and induce a regulatory phenotype in naive T cells. J. Immunol. 176: 6752-6761. [PubMedID:16709834]

Flies et al. (2011) Immunoglobulin light chain, Blimp-1 and cytochrome P4501B1 peptides as potential vaccines for AL amyloidosis.  Immunology and Cell Biology epub [PubMedID:21894172]

Fleissner et al (2010) Local Induction of Immunosuppressive CD8+ T Cells in the Gut-Associated Lymphoid Tissues . PLoS One 5:e15373 [PubMedID:20975955]

Franck et al (2012) Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactive CD8+T cells. PloS One 7:5 [PubMedID: 22570714]

Kb/RGYVYQGL (VSV)

Fuertes, M. et al (2011) Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells. Journal of Experimental Medicine. 208:2005  [PubMedID:21930765]

Ghio et al (2012) OxLDL- and HSP-60 antigen-specific CD8(+) T lymphocytes are detectable in the peripheral blood of patients suffering from coronary artery disease. Clinical and Experimental Medicine [PubMedID:22886609]

Guo et al (2009) Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigenB-cell-based cellular vaccine Gene Therapy 16:1300 [PubMedID:19641529]

Guo et al (2012) Deletion of FoxN1 in the Thymic Medullary Epithelium Reduces Peripheral T Cell Responses to Infection and Mimics Changes of Aging PLoS One 7:e34681 [PubMedID:22514652]

Han et al (2010) Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells from hematopoietic stem cells. Journal of Immune Based Therapies and Vaccines 8:8 [PubMedID:21106069]

Han et al (2009) Immunity of Lentiviral Vector-Modified Dendritic Cells. Methods in Molecular Biology 542:245 [PubMedID:19565906]

Hervouet, C. et al. (2010). Langerhans Cells Prime IL-17-Producing T cells and Dampten Genital Cytotoxic Responses following Mucosal Immunization. Journal of Immunology. 184: 4842-4851. [PubMedID:20351191]

Himoudi et al (2012) Human gamma delta T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells Journal of Immunology 188:1708 [PubMedID:22250090]

Hoppstädter et al (2012) Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation. European Journal of Immunology 42:1282[PubMedID:22539300]

Huang et al (2011) Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule. Nature Immunology 12:1086 [PubMedID:21964609]

Isa, A. et al. (2005). Prolonged activation of virus-specific CD8⁺ T cells after acute B19 infection. PLoS Med. 2: e343. (Epub) [PubMedID: 16253012]

Jakel, S. et al. (2009). Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis. Am. J. Pathol. 175: 510-518. [PubMedID:19590042]

H-2Db/FRHNNVTLM (VP2)
H-2Kb/TLPAFSTL (P3D)

Jelinek I., et al (2011) TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection.  Journal of Immunology 186(4):2422-9.[PubMedID:21242525]

H-2Kb/SIINFEKL (Ovalbumin)

Jeras et al (2010) Induction/engineering, detection, selection, and expansion of clinical-grade human antigen-specific CD8 cytotoxic T cell clones for adoptive immunotherapy. Journal of Biomedicine and Biotechnology 2010:705215 [PubMed:20224660]

Joeckel et al (2011) Mouse granzyme K has pro-inflammatory potential. Cell Death Differentiation 18:1112[PubMedID:21311565]

Jones et al (2009) Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. European Journal of Immunology 39:3195 [PubMedID:19658091]

Kandasamy et al (2011) Lactobacillus rhamnosus GG secreting an antigen and Interleukin-2 translocates across the gastrointestinal tract and induces an antigen specific immune response. Microbiology and Immunology 55:704 [PubMedID:21806675]

Kokolus et al (2013) Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature. PNAS [PubMedID:24248371]

H-2Ld/SPSYVYHQF

Kvistborg et al (2009) Fast generation of dendritic cells. Cellular Immunology 260:56 [PubMedID:19818956]

Lambeck et al (2010) Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens. Vaccine 28:4275 [PubMedID:20434555]

Lepone, L. et al. (2010). Monofunctional and Polyfunctional CD8⁺ T Cell Responses to Human Herpesvirus 8 Lytic and Latency Proteins. Clinical and Vaccine Immunolog 17 1507-1516. [PubMedID:20719985]

A*02:01/QMARLAWEA
A*02:01/LLNGWRWRL
A*02:01/LMWYELSKI
A*02:01/LVLILYLLCV
A*02:01/WATESPIYV

Lopes et al. (2011). A lentiviral vector pseudotype suitable for vaccine development. Journal of Gene Medicine. 13:181.[PubMedID: 21394858]

Luckashenak, N. et al. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells control CD8⁺T cell tolerance in vivo. Immunity. 28: 521-532.[PubMedID: 18387832]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SSIEFARL (HSV-gpB)
H-2Kb/TSYKFESV (vaccinia virus B8R)

Martinuzzi et al. (2011) Accelerated co-cultured dendritic cells (acDCs) enhance human antigen-specific T-cell responses. Blood 118:2128 [PubMedID: 21715316]

Matrai et al. (2011). Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. Hepatology. 53:1696  [PubMedID: 21520180]

Matter, M. et al. (2006). Elimination of chronic viral infection by blocking CD27 signaling. J. Exp. Med. 203: 2145-2155. [PubMedID: 16923852]

Mazzarella, G. et al (2008). Gliadin activates HLA class-1-restricted CD8⁺ T cells in celiac disease intestinal mucosa and induces enterocyte apoptosis. Gastroenterology. 134: 1017-1027. [PubMedID: 18395083]

A*02:01/QLIPCMDVVL (Gliadin pA2)
A*02:01/SLYNTVATL (HIV-1 gag17)

Mbitikon-Kobo et al (2009) Characterization of a CD44/CD122int memory CD8 T cell subset generated under sterile inflammatory conditions. Journal of Immunology 182:3846 [PubMedID:19265164]

Möller et al (2008) Dendritic Cell Maturation With Poly(I:C)-based Versus PGE2-based Cytokine Combinations Results in Differential Functional Characteristics Relevant to Clinical Application. Journal of Immunotherapy 31:506 [PubMedID:18463533]

Negri et al (2010) Transduction of Human Antigen-Presenting Cells with Integrase-Defective Lentiviral Vector Enables Functional Expansion of Primed Antigen-Specific CD8+ T Cells. Human Gene Therapy 21:1029[PubMedID:20210625]

Nishimoto et al (2011) Modification of human embryonic stem cell-derived dendritic cells with mRNA for efficient antigen presentation and enhanced potency. Regenerative Medicine 6:303 [PubMedID:21548736]

Omoto et al. (2010). Granzyme B is a novel interleukin-18 converting enzyme. Journal of Dermatological Science 59:129  [PubMedID:20621450]

H-2Kd/GYKDGNEYI (Listeriolysin O)
H-2Kd/RRLGRTLLL (Polyoma virus middle T protein)

Opitz et al (2011) Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis. PloS Pathogens 7:e1002233 [PubMedID:21909276]

Ortner et al (2011) The Adaptor Protein Bam32 in Human Dendritic Cells Participates in the Regulation of MHC Class I-Induced CD8+ T Cell Activation Journal of Immunology 187:3972 [PubMedID:21930970]

Pagni, PP (2014) Combination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model. Diabetes. 63(6). pp2015-25. [PubMedID: 24520125]

Panoskaltsis-Mortari, A. et al. (2008). In situ identification of allospecific B cells using pentamers. Blood 111: 3904-5. [PubMedID:18362221]

Perona-Wright et al. (2012). Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. PNAS epub. [PubMedID:23091017]

Sacquin et al (2012) Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected mice. Brain, Behavior, and Immunity[PubMedID:22522067]

Shimizu et al. (2010). HLA-B62 as a possible ligand for the human homologue of mouse macrophage MHC receptor 2 (MMR2) on monocytes. Gene 454:31. [PubMedID:20123006]

Smith et al (2012) Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells. Blood [PubMedID:22942184]

Soderquest et al. (2011). Cutting Edge: CD8+ T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses.  Journal of Immunology 186:3304  [PubMedID:21307295]

Sofra et al (2009) Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection. European Journal of Immunology 39:85 [PubMedID:19089809]

Stone et al (2011). Interaction of Streptavidin-Based Peptide–MHC Oligomers (Tetramers) with Cell-Surface TCRs Journal of Immunology epub [PubMedID:22102724]

Suchard (2012). Missing: A diagnostic technique to enumerate antigen-specific T cells. Crit. Rev. Oncol./Hematol. 83:276. [PubMedID:22137827]

Svensson, A. et al. (2005). Neurokinin 1 receptor signaling affects the local innate immune defense against genital Herpes virus infection. J. Immunol. 175: 6802-6811. [PubMedID:16272337]

H-2Kb/SSIEFARL (HSV-1 gp B)

Svensson, A. et al. (2005). Protective immunity to genital herpes simplex virus type 2 infection is mediated by T-bet. J. Immunol. 174: 6266-6273. [PubMedID:15879125]

H-2Kb/SSIEFARL (HSV-1 gp B)

Tellam et al. (2012). Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1. PLoS Path. 8:e1003112.[PubMedID:PMC3531512]

Rigato, P. et al. (2011). Heterologous plasmid DNA prime-recombinant human adenovirus 5 boost vaccination generates a stable pool of protective long-lived CD8+ T effector memory cells specific for a human parasie, Trypanosoma Cruzi.  Infection and Immunity. in press. [PubMedID:21357719]

Takamura, S. et al. (2010) Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+ T Cells by Rapid Induction of Multiple Inhibitory Receptors.  Journal of Immunology 184: 4696-4707[PubMedID:20351188]

H-2Db/CCLCLTVFL (F-MuLV gag 75-83)

Tan et al. (2011). Retinoic Acid as a Vaccine Adjuvant Enhances CD8+ T Cell Response and Mucosal Protection from Viral Challenge. Journal of Virology. 85:8316. [PubMedID:21653670]

Tamminen et al (2012) A comparison of immunogenicity of norovirus GII-4 virus-like particles and P-particles. Immunology 135:89 [PubMedID:22044070]

Tashiro-Yamaji et al. (2012) Specific binding of HLA-B44 to human macrophage MHC receptor 1 on monocytes Gene [PubMedID:22525042]

Tashiro-Yamaji et al. (2006). Macrophage MHC receptor 2: A novel receptor on allograft (H-2DdKd)-induced macrophage (H-2DbKb) recognizing an MHC class I molecule, H-2Kd, in mice. Gene. 384:1[PubMedID:17010536]

Tosello et al (2009) Differential expression of constitutive and inducible proteasome subunits in human monocyte-derived DC differentiated in the presence of IFN-α or IL-4.  European Journal of Immunology 39:56[PubMedID:19065646]

Tosiek et al. (2011). CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation. Journal of Immunology 186:6106  [PubMedID:21518973]

Tseng et al (2009) Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells. Regenerative Medicine 4:513 [PubMedID:19580370]

Uto et al. (2011). Comparative activity of biodegradable nanoparticles with aluminum adjuvants: Antigen uptake by dendritic cells and induction of immune response in mice. Immunology Letters 140:36[PubMedID:21693134]

Ventre et al (2012) Negative Regulation of NKG2D Expression by IL-4 in Memory CD8 T Cells. Journal of Immunology [PubMedID:22942430]

Verschelde, C. et al. (2006). Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection. Cell Death Differ. 13: 1213-1221. [PubMedID:16294210]

Vollers et al (2008) Class II major histocompatibility complex tetramer staining: progress, problems, and prospects. Immunology 123:305 [PubMedID:18251991]

Wickham, S. et al. (2005). Chemokine receptor deficiency is associated with increased chemokine expression in the peripheral and central nervous systems and increased resistance to herpetic encephalitis. J. NeuroImmunol. 162: 51-59. [PubMedID:15833359]

H-2Kb/SSIEFARL (HSV-1 gp B)

Yang, W. et al. (2007). Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML). Int. Immunol. 19: 1083-1093 [PubMedID:17660502]

Zelenay et al (2012) The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice Journal of Clinical Investigation [PubMedID:22505458]

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Model Antigen

Abdel-Motel, UM. et al. (2009). Mechanism for increased immunogenicity of vaccines that form in vivo immune complexes with the natural anti-Gal antibody. Vaccine. 27: 3072-3082. [PubMedID: 19428921]

H-2Kb/SIINFEKL (Ovalbumin)

Adriouch et al (2011) Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer. Frontiers In Microbiology 2:199 [PubMedID:22046170]

Amidi et al (2012) Induction of humoral and cellular immune responses by antigen-expressing immunostimulatory liposomes. Journal of Controlled Release [PubMedID:22940204]

Annoni, A. et al. (2009). In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance. Blood. 114: 5152-5161. [PubMedID: 19794140]

H-2Kd/HYLSTQSAL (eGFP)

Arnaboldi, PM. et al. (2009). Suppression of Th1 and Th17, but not Th2, responses in a CD8⁺ T cell-mediated model of oral tolerance. Mucosal Immunology. 2: 427-438. [PubMedID: 19571798]

H-2Kb/SIINFEKL (Ovalbumin)

Bahjat, K.S. et al. (2006). Cytosolic Entry Controls CD8 + T cell Potency During Bacterial Infection. Infect. Immun. 74: 6387-6397. [PubMedID: 16954391]

H-2Kb/SIINFEKL (Ovalbumin)

Bahjat, K. et al. (2009). Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria. PLos Pathogens. 5: e1000568 [PubMedID:19730694]

H-2Kb/SIINFEKL (Ovalbumin)

Binder, R.et al. (2005). Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8⁺ T cells. Nature Immunol. 6: 593-599. [PubMedID: 15864309]

H-2Kb/SIINFEKL (Ovalbumin)

Black et al (2012) Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo. Advanced Materials 24:3845 [PubMedID:22550019]

Bouma, G. et al. (2007). Impaired T cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood. 110: 4278-84 [PubMedID:17673604]

H-2Kb/SIINFEKL (Ovalbumin)

Bourquin, C. et al. (2007). Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T cell and IgG2a response. Blood 109: 2953-2960. [PubMedID:17132722]

H-2Kb/SIINFEKL (Ovalbumin)

Brinkman et al (2004) Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity. Letters in Drug Design and Discovery 1:137

Chapman et al (2012) Platelets Present Antigen in the Context of MHC Class I. Journal of Immunology 189:916[PubMedID:22706078]

Connolly, MK. et al. (2009). In liver fibrosis, dendritc cells govern hepatic inflammation in mice via TNF-a. J. Clin. Invest. 119: 3213-3225 [PubMedID:19855130]

H-2Kb/SIINFEKL (Ovalbumin)

Cuburu et al (2007) Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine 51:8598 [PubMedID:17996991]

Daniel, B. et al. (2010). A simple method to detect Toxoplasma Gondii-specific cytotoxic T cells in vivo. J. Imm. Methods, 355: 86-90 [PubMedID:20149795]

H-2Kb/SIINFEKL (Ovalbumin)

Diebold, SS. et al. (2008). Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines. Gene Therapy. 16: 359-366 [PubMedID: 19052633]

H-2Kb/SIINFEKL (Ovalbumin)

D’Orsogna et al (2012) Detection of allo-HLA cross-reactivity by virus-specific memory T-cell clones using single HLA-transfected K562 cells. Methods in Molecular Biology 882:339 [PubMedID:22665243]

Derbyshire et al (2011) Molecular mechanisms of induction of antigen-specific allograft tolerance by intranasal peptide administration. J. Immunol. 186:5719. [PubMedID:21490154]

Eby et al (2012) Polymer micelles with pyridyl disulfide-coupled antigen traffic through lymphatics and show enhanced cellular responses following immunization. Acta Biomaterialia [PubMedID:22698945]

Franck et al (2012) Immunological Tolerance to Muscle Autoantigens Involves Peripheral Deletion of Autoreactive CD8+ T Cells. PLoS One 7: e36444 [PubMedID:22570714]

Furmanski et al (2010) Peptide-Specific, TCR-α–Driven, Coreceptor-Independent Negative Selection in TCR α-Chain Transgenic Mice. J. Immunol. 184:650. [PubMedID:19995903]

Ga, M. et al. (2007). Single CX3CL1-Ig DNA administration enhances T cell priming in vivo. Vaccine 25: 4554-63. [PubMedID:[17493713]

H-2Kb/SIINFEKL (Ovalbumin)

Gerbitz et al (2012) Stromal Interferon-γ Signaling and Cross-Presentation Are Required to Eliminate Antigen-Loss Variants of B Cell Lymphomas in Mice.PLoS One 7:e34552 [PubMedID:22479645]

Goold, H. et al. (2011). Conventional Dendritic Cells Are Required for the Activation of Helper-Dependent CD8 T Cell Responses to a Model Antigen After Cutaneous Vaccination with Lentiviral Vectors. Journal of Immunology 186: 4565-72 [PubMedID: 21389256]

H-2Kb/SIINFEKL (Ovalbumin)

Gottrand et al (2012) Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice. Journal of Gene medicine [PubMedID:22228582]

Govers et al (2012) Magnetic-Activated Cell Sorting of TCR-engineered T cells using tCD34 as a gene marker, but not pMHC multimers, results in significant numbers of functional CD4 and CD8 T cells. Human Gene Therapy Methods [PubMedID:22746173]

Gutermuth, J. et al. (2009). Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V{alpha}2 down-regulation. J. Immunol. 183: 3130-3138.[PubMedID: 19675167]

H-2Kb/SIINFEKL (Ovalbumin)

Harms, JS. et al. (2009) Evaluation of recombinant invasive, non-pathogenic Eschericia coli as a vaccine vector against the intracellular pathogen, Brucella. Journal of Immune Based Therapies and Vaccines. 7: 1[PubMedID: 19126207]

H-2Kd/HYLSTQSAL (eGFP)

Hamasaki, T. et al. (2010).  Modulation of Gene Expression Related to Toll-Like Receptor Signaling in Dendritic Cells by Poly(g-Glutamic Acid) Nanoparticles.  Clinical and Vaccine Immunology 17: 748-276 [PubMedID: 20219877]

H-2Kb/SIINFEKL (Ovalbumin)

Heffernan et al (2011) In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines. Biomaterials 32:926 [PubMedID:20965561]

Hegazy et al (2012) Evaluation of Salmonella enterica Type III Secretion System Effector Proteins as Carriers for Heterologous Vaccine Antigens Infection and Immunity 80:1193 [PubMedID:22252866]

Hinterleitner et al (2012) Adoptive Transfer of siRNA Cblb-Silenced CD8+ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model. PLoS One 7:e44295 [PubMedID:22962608]

Howland et al (2008) Inducing Efficient Cross-priming Using Antigen-coated Yeast Particles. Journal of Immunotherapy 31:607 [PubMedID:18600183]

Hubert, S. et al. (2010).  Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.  Journal of Experimental Medicine [PubMedID: 20975043]

H-2Kb/SIINFEKL (Ovalbumin)

Johansson et al (2012) Intradermal Electroporation of Naked Replicon RNA Elicits Strong Immune Responses. PLoS One 7:e29732 [PubMedID:22238645]

Joshi et al (2012) Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation Journal of Leukocyte Biology epub [PubMedID:22331103]

H-2Kb/SIINFEKL (Ovalbumin)

Khan et al (2011) Regulation of T Cell Priming by Lymphoid Stroma. PLoS One 6: e26138[PubMedID:22110583]

Kuipers, H. et al. (2010) Dicer-Dependent MicroRNAs Control Maturation, Function, and Maintenance of Langerhans Cells In Vivo. J. Immunology. 185:400-409 . [PubMedID:20530258]

H-2Kb/SSIEFARL

Leggat, JA. et al. (2008). Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization. J. Allergy Clin. Immunol. 122: 1014-1021. [PubMedID:18804851]

H-2Kb/SIINFEKL (Ovalbumin)

Li et al. (2012). Dendritic cells sequester antigenic epitopes for prolonged periods in the absence of antigen-encoding genetic information. PNAS 109:17543. [PubMedID:23045695]

H-2Kb/SIINFEKL (Ovalbumin)

Luci, C. et al. (2006). Dendritic cell-mediated induction of mucosal cytotoxic responses following intravaginal immunization with the non-toxic B subunit of Cholera toxin. J. Immunol. 176: 2749-2757. [PubMedID:16493030]

H-2Kb/SIINFEKL (Ovalbumin)

Luckashenak, N. et al. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells control CD8⁺T cell tolerance in vivo. Immunity. 28: 521-532. [PubMedID:18387832]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SSIEFARL (HSV-gpB)
H-2Kb/TSYKFESV (vaccinia virus B8R)

Lund et al (2012) VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics Cell Reports epub

Martin-Orozco, et al. (2006). Programmed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens. J. Immunol. 177: 8291-8295. [PubMedID:17142723]

H-2Kb/SIINFEKL (Ovalbumin)

Mascolo, D. et al. (2007). Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response. FEMS Immunol. Med. Microbiol. 50: 59-66. [PubMedID: 17391361]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SSYSYSSL

McBurney, WT. et al. (2008). In vivo activity of cationic immune stimulating complexes (PLUSCOMs). Vaccine. 26: 4549-4556 [PubMedID: 18585421]

H-2Kb/SIINFEKL (Ovalbumin)

McIlroy, D. et al. (2009). DNA/Amphiphilic block copolymer nanospheres promote low-dose DNA vaccination. Mol. Ther. 17: 1473-1481 [PubMedID: 19417740]

H-2Kb/SIINFEKL (Ovalbumin)

Moreau et al (2012) Absence of Galectin-1 accelerates CD8+ T cell-mediated graft rejection. European Journal of Immunology [PubMedID:22865279]

Mouries, J. et al. (2008). Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation. Blood. 112: 3713-3722 [PubMedID: 18698004]

H-2Kb/SIINFEKL (Ovalbumin)

Myschik et al (2008) Immunostimulatory biodegradable implants containing the adjuvant Quil-A—Part II: In vivo evaluation Journal of Drug Targeting 16:224 [PubMedID:18365884]

Myschik et al (2008) Immunogenicity of lipid sustained release implants containing imiquimod, α-galactosylceramide, or Quil-A . Die Pharmazie 63:686 [PubMedID:18819523]

Negri et al (2012) Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines. Retrovirology 9:69 [PubMedID:22913641]

Noble, A. et al. (2006). Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage. Blood 107: 4475-4483. [PubMedID:16467201]

H-2Kb/SIINFEKL (Ovalbumin)

Nordly et al (2011) Immunity by formulation design: Induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method. Journal of Controlled Release 150:307[PubMedID:21111765]

Nordly, P. et al. (2010). Incorporation of the TLR4 Agonist Monophosphoryl Lipid A Into the Bilayer of DDA/TDB Liposomes: Physico-Chemical Characterization and Induction of CD8(+) T-Cell Responses In Vivo. Pharmaceutical Research [PubMedID:21042837]

H-2Kb/SIINFEKL (Ovalbumin)

Nouri-Shirazi et al (2012) Exposure to Nicotine Adversely Affects the Dendritic Cell System and Compromises Host Response to Vaccination Journal of Immunology 188:2359 [PubMedID:22279108]

Papatriantafyllou et al (2012) Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance. PNAS 109: 1631 [PubMedID:22307622]

Pascual, DW. et al. (2008). The absence of lymphoid CD8⁺ dendritic cell maturation in L-selectin^-/- respiratory compartment attenuates antiviral immunity J Immunol. 181: 1345-1356 [PubMedID: 18606689]

H-2Kb/SIINFEKL (Ovalbumin)

Puaux, A-L et al. (2006) A very rapid and simple assay based on trogocytosis to detect and measure specific T and B cell reactivity by flow cytometry. Eur. J. Immunol. 36: 779-788. [PubMedID:16482513]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Db/KAVYNFATC (LCMV GP1)

Ren, Y. et al. (2006). OVA-specific CD8+ T cells do not express granzyme B during anterior chamber associated immune deviation. Graefes Arch. Clin. Exp. Ophthalmol. 244: 1315-1321. [PubMedID:16538449]

H-2Kb/SIINFEKL (Ovalbumin)

Reuter et al (2012) Foxp3 regulatory T cells control persistence of viral CNS infection.PLoS One 7:e33989[PubMedID:22448284]

Rolf et al. (2012). AMPKα1: A glucose sensor that controls CD8 T-cell memory. Eur. J. Immunol. Epub.[PubMedID:23310952]

H-2Kb/SIINFEKL (Ovalbumin)

Rowe, HM. et al. (2009). Expression of vFLIP in a lentiviral vaccine vector activates NF-kB matures dendritic cells and increases CD8⁺ T-cell responses. J. Virol. 83: 1555-1562 [PubMedID: 19036811]

H-2Kb/SIINFEKL (Ovalbumin)

Sakamoto, N et al. (2011). Apolipoprotein B Binding Domatins: Evidence That They Are Cell-Penetrating Peptides That Efficiently Deliver Antigenic Peptide for Cross-Presentation of Cytotoxic T Cells. Journal of Immunology 186: 5004-5011. [PubMedID:21402897]

H-2Kb/SIINFEKL (Ovalbumin)

Saveanu, L. et al. (2009). IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science. 325: 213-217. [PubMedID:19498108]

H-2Kb/SIINFEKL (Ovalbumin)

Schwandt et al (2011) Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis EMBO Journal  [PubMedID:22036947]

Stano et al (2011) PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration. Vaccine 29:804 [PubMedID:21094269]

Terabe, M. et al. (2008). IL-15 expands unconventional CD8aa NK1.1⁺T cells but not Va14Ja18⁺ NKT cells. J Immunol. 180: 7276-7286. [PubMedID:18490727]

H-2Kb/SIINFEKL (Ovalbumin)

Thangavelu et al (2011) The role of co-inhibitory signals in spontaneous tolerance of weakly mismatched transplants Immunobiology 216:918 [PubMedID:21281982]

Thomas et al (2012) Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage. Journal of Immunology 189:2181 [PubMedID:22844119]

Thompson, JM. et al. (2008). Alphavirus replicon particlaes acting as adjuvants promote CD8⁺ T cell responses to co-delivered antigen. Vaccine. 26: 4267-4275 [PubMedID:18585421]

H-2Kb/SIINFEKL (Ovalbumin)

Tomihara et al (2011) Aging-associated B7-DC(+) B cells enhance anti-tumor immunity via Th1 and Th17 induction. Aging Cell 11:128[PubMedID:22044484]

Tripp et al (2010) Conditioning of the Injection Site With CpG Enhances the Migration of Adoptively Transferred Dendritic Cells and Endogenous CD8+ T-cell Responses. Journal of Immunotherapy 33:115[PubMedID:20145551]

Tripp, CH. et al. (2009). Glycolipids injected into the skin are presented to NKT cells in the draining lymph node independently of migratory skin dendritic cells. J. Immunol. 182: 7644-7654. [PubMedID:19494288]

H-2Kb/SIINFEKL (Ovalbumin)

Uto, T. et al. (2009). Improvement of adaptive immunity by antigen-carrying biodegradable nanoparticles. Biochem. Biophys. Res. Comm. 379:600-604 [PubMedID:19121627]

H-2Kb/SIINFEKL (Ovalbumin)

Warncke et al (2011). Control of the specificity of T cell-mediated anti-idiotype immunity by natural regulatory T cells. Cancer Immunol. Immunothera. 60:49. [PubMedID:20848095]

Wells, JW. et al (2008). Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J Immunol. 181: 3422-3431 [PubMedID:18714014]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SVYDFFVWL (TRP-2)

Wells, JW. et al. (2009). Suppression of allergic airway inflammation and IgE responses by a class I restricted allergen peptide vaccine. Mucosal Immunology 2: 54-62 [PubMedID:19079334]

H-2Kb/SIINFEKL (Ovalbumin)

Yamasaki et al. (2012). Intravenous genetic mesothelin vaccine based on human adenovirus 40 inhibits growth and metastasis of pancreatic cancer. Int. J. Cancer epub. [PubMedID:23233329]

H-2Kb/SIINFEKL (Ovalbumin)

Zheng et al. (2012). Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo. JEM 209:2157-2163. [PubMedID:23129747]

H-2Kb/SIYRYYGL (Synthetic variant of VSV Nucleoprotein 498–505)

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Immunity Research citing the use of ProImmune Pentamers

Have you published a paper citing the use of ProImmune’s products or services? If so, please send us a reprint as a PDF by e-mail to enquiries@www.proimmune.com. We will send you a bottle of Champagne to celebrate with! (Limited to 1 bottle per publication).

 

Allergy	Autoimmunity
Minor Histocompatibility Antigen (miHAg)	Other

Model Antigen

 

Allergy

Woodfolk J.A.  (2007) T-cell responses to allergens. Journal of Allergy and Clinical Immunology 119:280[PubMedID:17291848]

 

Autoimmunity

Ankathatti Munegowda et al  (2011) A Distinct Role of CD4(+) Th17- and Th17-Stimulated CD8(+) CTL in the Pathogenesis of Type 1 Diabetes and Experimental Autoimmune Encephalomyelitis. J Clin Immunol.[PubMedID: 21674137]

Arce F. et al  (2011) Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis. Arthritis Rheum. 63(1):84-95 [PubMedID:20967853]

Crampton et al (2012) Ifih1 Gene Dose Effect Reveals MDA5-Mediated Chronic Type I IFN Gene Signature, Viral Resistance, and Accelerated Autoimmunity.  Journal of Immunology 188:1451 [PubMedID:22205024]

Engkilde, K. et al (2011) Prevention of type 1 diabetes by inducing subclinical dermatitis on a small area Diabetes and Metabolism Research and Reviews. 27: 954

Fierabracci, A. (2011) The potential of multimer technologies in type 1 diabetes prediction strategies. Diabetes and Metabolism Research and Reviews. 27: 216-229 [PubMedID: 21309048]

Freed et al (2011) Association of the HLA–DRB1 epitope LA67, 74 with rheumatoid arthritis and citrullinated vimentin binding. Arthritis and Rheumatism 63:3733 [PubMedID:22094856]

Giuliani et al (2009) Detection of GAD65 Autoreactive T-Cells by HLA Class I Tetramers in Type 1 Diabetic Patients. Journal of Biomedicine and Biotechnology 2009:576219 [PubMedID:20029631]

Ha et al (2010) Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity. Journal of Clinical Investigation 120:4273 [PubMedID:21084750]

Ohnmacht, C. et al. (2009). Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J. Exp. Med. 206: 549-559 [PubMedID: 19237601]

H-2Kb/SIINFEKL (Ovalbumin)

Mallone, R. et al (2011) Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report—HLA Class I Tetramer Validation Initiative Diabetes and Metabolism Research and Reviews. 27: 720 [PubMedID:22069251]

Matthis et al (2012) T Cell Autoreactivity in the Transplant Milieu. American J. Transplant. 12:1674[PubMedID:22642536]

Monti, P. et al. (2008) Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J. Clin. Invest. 118: 1806-1814 [PubMedID: 18431516]

A*02:01/VMNILLQYV (GAD 65)
A*02:01/GILGFVFTL (Flu-A MP)
A*02:01/SLYNTVATL (HIV gag p17)

Monti, P. et al. (2007). Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J. Immunol. 179: 5785-92. [PubMedID: 17947651].

A*02:01/VMNILLQYV (GAD 65)
A*02:01/GILGFVFTL (Flu-A MP)
A*02:01/SLYNTVATL (HIV gag p17)

Munoz-Suano et al (2011) Regulatory T cells protect from autoimmune arthritis during pregnancy. Journal of Autoimmunity 38:J103 [PubMedID:22004905]

Van Belle et al. (2011). Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model. J. Immunol. 187: 2915 [PubMedID:21832162].

Van Belle et al (2012) Interleukin-21 Receptor-Mediated Signals Control Autoreactive T Cell Infiltration in Pancreatic Islets Immunity 36:1060 [PubMedID:22579473]

Van Belle et al (2012) NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes. Journal of Autoimmunity [PubMedID:22944096]

Weyd, H. et al (2013) Annexin A1 on the surface of early apoptotic cells suppresses CD8+ T cell immunity. PLoS One 8(4):e62449 [PubMedID:23638088]

H-2Kb/SIINFEKL (Ovalbumin 257-264)

Zierden et al (2010) Effects and Regulation of Autoreactive CD8+ T Cells in a Transgenic Mouse Model of Autoimmune Hepatitis Gastroenterology 139:975 [PubMedID:20639127]

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Minor Histocompatibility Antigen (MiHAg)

Baldwin, T. et al. (2005). The timing of TCRa expression critically influences T cell development and selection. J Exp Med. 202: 111-121. [PubMedID: 15998791

H-2Db/KCSRNRQYL (miHAg smcy)

D’Asaro, M. et al. (2006). Increase of CCR7(-) CD45RA(+) CD8 T cells (T(EMRA)) in chronic graft-versus-host disease. Leukemia 20: 545-547. [PubMedID:16408100]

A*02:01/FIDSYICQV (miHAg SMCY)

Fan, Y. et al. (2009). Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J. 28: 2812-2824. [PubMedID: 19680229]

H-2Db/WMHHNMDLI (miHAg UTY)

Flutter, B. et al. (2010). Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.Journal of Clinical Investigation[PubMedID: 20978352]

H-2Kb/LTFNYRNL(miHAg)

Eiz-Vesper, B. et al. (2006). Tetanus toxoid provides efficient T-cell help for the induction of HA-1(H) cytotoxic T cells. Transfusion 46: 1210-1220. [PubMedID:16836569]

Hu, Q. et al. (2009). Bim-mediated Apoptosis in not necessary for thymic negative selection to ubiquitous self-antigens. J. Immunol. 183: 7761-7767. [PubMedID: 19933852]

H-2Db/KCSRNRQYL (miAg SMCY)

Kwun et al (2011) Primary Vascularization of the Graft Determines the Immunodominance of Murine Minor H Antigens during Organ Transplantation. Journal of Immunology epub [PubMedID: 21900176]

Kwun, J. et al. (2007) Altered distribution of H60 minor H Antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- Mouse Recipients. J Immunol. 179: 8016-8025. [PubMedID: 18056341]

H-2Kb/SGIVYIHL (H4b)
H-2Kb/KAPDNRDTL (H7b)
H-2Kb/SSVIGVWYL (H13b)
H-2Kb/ILENFPRL (H28)

Michelini, R. et al. (2010) Concomitant Tumor and Minor Histocompatibility Antigen-Specific Immunity Initiate Rejection and Maintain Remission from Established Spontaneous Solid Tumours. Cancer Research. 70(9): 3505-14. [PubMedID: 20388780]

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Other

Allen S., et al (2011) The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus type 1.  Journal of Virology. 85: 4814 [PubMedID: 21307196]

H-2Kb/SSIEFARL (HSV-1 gp B)

Argani et al (2011) Characterization of herpes simplex virus 1 strains as platforms for the development of oncolytic viruses against liver cancer. Liver International 31: 1542 [PubMedID: 22093330] 

Attig et al (2011) A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols. Journal of Translational Medicine 9:108 [PubMedID:21745365]

Baschuk, N. et al. (2007). Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice. Cancer Immunol. Immunother. 56: 1625-36. [PubMedID: 17431618]

H-2Kb/VVYDFLKL (SV40 tag)

Bernardo et al (2011) Phenotypic and functional evaluation of CD3+CD4-CD8- T cells in human CD8 immunodeficiency. Haematologica 96:1195 [PubMedID:21546492]

Cantisan et al (2010) CD45RA expression on HCMV-specific effector memory CD8+ T cells is associated with the duration and intensity of HCMV replication after transplantation. Clinical Immunology 137:81[PubMedID:20674505]

Carr, D.J.J. et al. (2006). The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection. Immunology 118: 520-526. [PubMedID:16895559]

H-2Kb/SSIEFARL (HSV-1 gp B)

Castella et al. (2011). Immune Modulation by Zoledronic Acid in Human Myeloma: An Advantageous Cross Talk between Vg9Vδ2 T Cells, αβ CD8+ T Cells, Regulatory T Cells, and Dendritic Cells. Journal of Immunology epub. [PubMedID:21753152]

Cento et al (2011) Intratype Variation of HPV 31 and 58 in Italian women with abnormal cervical cytology. J Med Virol. 83:1752 [PubMedID:21837791]

Chang (2011) Lentiviral Vector Transduction of Dendritic Cells for Novel Vaccine Strategies. Methods in Molecular Biology 614:161 [PubMedID:20225043]

Chappert et al (2010) Antigen-specific Treg impair CD8+ T-cell priming by blocking early T-cell expansion. European Journal of Immunology 40:339 [PubMedID:19877007]

Chatterjee et al (2012) Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells  Blood [PubMedID:22791285]

Cheent et al (2013) Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. PNAS. 110:42 [PubMedID: 24082146]

E*01:01 / VMAPRTLIL (HLA-E)

Circosta et al (2009) T Cell Receptor (TCR) Gene Transfer with Lentiviral Vectors Allows Efficient Redirection of Tumor Specificity in Naive and Memory T Cells Without Prior Stimulation of Endogenous TC. Human Gene Therapy 20:1576 [PubMedID:19678763]

Claassen, EA. et al. (2007). Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity. Virology. 368: 17-25. [PubMedID: 17632195]

H-2Kd/CYLTDRARI (PVM G)

Claassen, E.A. (2005). Activation and inactivation of antiviral CD8 T cell responses during murine pneumovirus infection. J. Immunol. 175: 6597-6604. [PubMedID:16272314]

H-2Kd/CYLTDRARI (PVM G)

Davis et al (2011) Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis. Nature Reviews Immunology 11:551.  [PubMedID:21760610]

Degauque et al. (2011)  The Blood of Healthy Individuals Exhibits CD8 T Cells with a Highly Altered TCR Vb Repertoire but with an Unmodified Phenotype. PLoS One 6: e21240 [PubMedID: 21738624]

Dervovic et al. (2012) Comparative and Functional Evaluation of In Vitro Generated to Ex Vivo CD8 T Cells. J. Immunol. 189:3411 [PubMedID: 22925927]

Duewell et al. (2011) ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells. Journal of Immunology 187:55 [PubMedID: 21613613]

Dudek et al. (2011) Evidence for differences in immunologic and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa. Journal of Infectious Diseases 203:1434  [PubMedID: 21498376]

Dudek, T. et al. (2008) Disruption of the U_L41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes. Virology. 372: 165-175[PubMedID: 18006033]

H-2Kb/SSIEFARL (HSV gpB)

Duplan, V. et al. (2007). Tracking antigen-specific CD8⁺ T cells in the rat using MHC class I multimers. J. Immunol. Methods 320: 30-39. [PubMedID:17223126]

First custom Pentamer synthesized for rat MHC

Edelson et al (2010) Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. Journal of Experimental Medicine 207:823 [PubMedID:20351058]

Fallarino, F. et al. (2006). The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor z chain and induce a regulatory phenotype in naive T cells. J. Immunol. 176: 6752-6761. [PubMedID:16709834]

Flies et al. (2011) Immunoglobulin light chain, Blimp-1 and cytochrome P4501B1 peptides as potential vaccines for AL amyloidosis.  Immunology and Cell Biology epub [PubMedID:21894172]

Fleissner et al (2010) Local Induction of Immunosuppressive CD8+ T Cells in the Gut-Associated Lymphoid Tissues . PLoS One 5:e15373 [PubMedID:20975955]

Franck et al (2012) Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactive CD8+T cells. PloS One 7:5 [PubMedID: 22570714]

Kb/RGYVYQGL (VSV)

Fuertes, M. et al (2011) Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells. Journal of Experimental Medicine. 208:2005  [PubMedID:21930765]

Ghio et al (2012) OxLDL- and HSP-60 antigen-specific CD8(+) T lymphocytes are detectable in the peripheral blood of patients suffering from coronary artery disease. Clinical and Experimental Medicine [PubMedID:22886609]

Guo et al (2009) Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigenB-cell-based cellular vaccine Gene Therapy 16:1300 [PubMedID:19641529]

Guo et al (2012) Deletion of FoxN1 in the Thymic Medullary Epithelium Reduces Peripheral T Cell Responses to Infection and Mimics Changes of Aging PLoS One 7:e34681 [PubMedID:22514652]

Han et al (2010) Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells from hematopoietic stem cells. Journal of Immune Based Therapies and Vaccines 8:8 [PubMedID:21106069]

Han et al (2009) Immunity of Lentiviral Vector-Modified Dendritic Cells. Methods in Molecular Biology 542:245 [PubMedID:19565906]

Hervouet, C. et al. (2010). Langerhans Cells Prime IL-17-Producing T cells and Dampten Genital Cytotoxic Responses following Mucosal Immunization. Journal of Immunology. 184: 4842-4851. [PubMedID:20351191]

Himoudi et al (2012) Human gamma delta T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells Journal of Immunology 188:1708 [PubMedID:22250090]

Hoppstädter et al (2012) Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation. European Journal of Immunology 42:1282[PubMedID:22539300]

Huang et al (2011) Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule. Nature Immunology 12:1086 [PubMedID:21964609]

Isa, A. et al. (2005). Prolonged activation of virus-specific CD8⁺ T cells after acute B19 infection. PLoS Med. 2: e343. (Epub) [PubMedID: 16253012]

Jakel, S. et al. (2009). Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis. Am. J. Pathol. 175: 510-518. [PubMedID:19590042]

H-2Db/FRHNNVTLM (VP2)
H-2Kb/TLPAFSTL (P3D)

Jelinek I., et al (2011) TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection.  Journal of Immunology 186(4):2422-9.[PubMedID:21242525]

H-2Kb/SIINFEKL (Ovalbumin)

Jeras et al (2010) Induction/engineering, detection, selection, and expansion of clinical-grade human antigen-specific CD8 cytotoxic T cell clones for adoptive immunotherapy. Journal of Biomedicine and Biotechnology 2010:705215 [PubMed:20224660]

Joeckel et al (2011) Mouse granzyme K has pro-inflammatory potential. Cell Death Differentiation 18:1112[PubMedID:21311565]

Jones et al (2009) Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. European Journal of Immunology 39:3195 [PubMedID:19658091]

Kandasamy et al (2011) Lactobacillus rhamnosus GG secreting an antigen and Interleukin-2 translocates across the gastrointestinal tract and induces an antigen specific immune response. Microbiology and Immunology 55:704 [PubMedID:21806675]

Kokolus et al (2013) Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature. PNAS [PubMedID:24248371]

H-2Ld/SPSYVYHQF

Kvistborg et al (2009) Fast generation of dendritic cells. Cellular Immunology 260:56 [PubMedID:19818956]

Lambeck et al (2010) Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens. Vaccine 28:4275 [PubMedID:20434555]

Lepone, L. et al. (2010). Monofunctional and Polyfunctional CD8⁺ T Cell Responses to Human Herpesvirus 8 Lytic and Latency Proteins. Clinical and Vaccine Immunolog 17 1507-1516. [PubMedID:20719985]

A*02:01/QMARLAWEA
A*02:01/LLNGWRWRL
A*02:01/LMWYELSKI
A*02:01/LVLILYLLCV
A*02:01/WATESPIYV

Lopes et al. (2011). A lentiviral vector pseudotype suitable for vaccine development. Journal of Gene Medicine. 13:181.[PubMedID: 21394858]

Luckashenak, N. et al. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells control CD8⁺T cell tolerance in vivo. Immunity. 28: 521-532.[PubMedID: 18387832]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SSIEFARL (HSV-gpB)
H-2Kb/TSYKFESV (vaccinia virus B8R)

Martinuzzi et al. (2011) Accelerated co-cultured dendritic cells (acDCs) enhance human antigen-specific T-cell responses. Blood 118:2128 [PubMedID: 21715316]

Matrai et al. (2011). Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. Hepatology. 53:1696  [PubMedID: 21520180]

Matter, M. et al. (2006). Elimination of chronic viral infection by blocking CD27 signaling. J. Exp. Med. 203: 2145-2155. [PubMedID: 16923852]

Mazzarella, G. et al (2008). Gliadin activates HLA class-1-restricted CD8⁺ T cells in celiac disease intestinal mucosa and induces enterocyte apoptosis. Gastroenterology. 134: 1017-1027. [PubMedID: 18395083]

A*02:01/QLIPCMDVVL (Gliadin pA2)
A*02:01/SLYNTVATL (HIV-1 gag17)

Mbitikon-Kobo et al (2009) Characterization of a CD44/CD122int memory CD8 T cell subset generated under sterile inflammatory conditions. Journal of Immunology 182:3846 [PubMedID:19265164]

Möller et al (2008) Dendritic Cell Maturation With Poly(I:C)-based Versus PGE2-based Cytokine Combinations Results in Differential Functional Characteristics Relevant to Clinical Application. Journal of Immunotherapy 31:506 [PubMedID:18463533]

Negri et al (2010) Transduction of Human Antigen-Presenting Cells with Integrase-Defective Lentiviral Vector Enables Functional Expansion of Primed Antigen-Specific CD8+ T Cells. Human Gene Therapy 21:1029[PubMedID:20210625]

Nishimoto et al (2011) Modification of human embryonic stem cell-derived dendritic cells with mRNA for efficient antigen presentation and enhanced potency. Regenerative Medicine 6:303 [PubMedID:21548736]

Omoto et al. (2010). Granzyme B is a novel interleukin-18 converting enzyme. Journal of Dermatological Science 59:129  [PubMedID:20621450]

H-2Kd/GYKDGNEYI (Listeriolysin O)
H-2Kd/RRLGRTLLL (Polyoma virus middle T protein)

Opitz et al (2011) Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis. PloS Pathogens 7:e1002233 [PubMedID:21909276]

Ortner et al (2011) The Adaptor Protein Bam32 in Human Dendritic Cells Participates in the Regulation of MHC Class I-Induced CD8+ T Cell Activation Journal of Immunology 187:3972 [PubMedID:21930970]

Pagni, PP (2014) Combination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model. Diabetes. 63(6). pp2015-25. [PubMedID: 24520125]

Panoskaltsis-Mortari, A. et al. (2008). In situ identification of allospecific B cells using pentamers. Blood 111: 3904-5. [PubMedID:18362221]

Perona-Wright et al. (2012). Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. PNAS epub. [PubMedID:23091017]

Sacquin et al (2012) Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected mice. Brain, Behavior, and Immunity[PubMedID:22522067]

Shimizu et al. (2010). HLA-B62 as a possible ligand for the human homologue of mouse macrophage MHC receptor 2 (MMR2) on monocytes. Gene 454:31. [PubMedID:20123006]

Smith et al (2012) Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells. Blood [PubMedID:22942184]

Soderquest et al. (2011). Cutting Edge: CD8+ T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses.  Journal of Immunology 186:3304  [PubMedID:21307295]

Sofra et al (2009) Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection. European Journal of Immunology 39:85 [PubMedID:19089809]

Stone et al (2011). Interaction of Streptavidin-Based Peptide–MHC Oligomers (Tetramers) with Cell-Surface TCRs Journal of Immunology epub [PubMedID:22102724]

Suchard (2012). Missing: A diagnostic technique to enumerate antigen-specific T cells. Crit. Rev. Oncol./Hematol. 83:276. [PubMedID:22137827]

Svensson, A. et al. (2005). Neurokinin 1 receptor signaling affects the local innate immune defense against genital Herpes virus infection. J. Immunol. 175: 6802-6811. [PubMedID:16272337]

H-2Kb/SSIEFARL (HSV-1 gp B)

Svensson, A. et al. (2005). Protective immunity to genital herpes simplex virus type 2 infection is mediated by T-bet. J. Immunol. 174: 6266-6273. [PubMedID:15879125]

H-2Kb/SSIEFARL (HSV-1 gp B)

Tellam et al. (2012). Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1. PLoS Path. 8:e1003112.[PubMedID:PMC3531512]

Rigato, P. et al. (2011). Heterologous plasmid DNA prime-recombinant human adenovirus 5 boost vaccination generates a stable pool of protective long-lived CD8+ T effector memory cells specific for a human parasie, Trypanosoma Cruzi.  Infection and Immunity. in press. [PubMedID:21357719]

Takamura, S. et al. (2010) Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+ T Cells by Rapid Induction of Multiple Inhibitory Receptors.  Journal of Immunology 184: 4696-4707[PubMedID:20351188]

H-2Db/CCLCLTVFL (F-MuLV gag 75-83)

Tan et al. (2011). Retinoic Acid as a Vaccine Adjuvant Enhances CD8+ T Cell Response and Mucosal Protection from Viral Challenge. Journal of Virology. 85:8316. [PubMedID:21653670]

Tamminen et al (2012) A comparison of immunogenicity of norovirus GII-4 virus-like particles and P-particles. Immunology 135:89 [PubMedID:22044070]

Tashiro-Yamaji et al. (2012) Specific binding of HLA-B44 to human macrophage MHC receptor 1 on monocytes Gene [PubMedID:22525042]

Tashiro-Yamaji et al. (2006). Macrophage MHC receptor 2: A novel receptor on allograft (H-2DdKd)-induced macrophage (H-2DbKb) recognizing an MHC class I molecule, H-2Kd, in mice. Gene. 384:1[PubMedID:17010536]

Tosello et al (2009) Differential expression of constitutive and inducible proteasome subunits in human monocyte-derived DC differentiated in the presence of IFN-α or IL-4.  European Journal of Immunology 39:56[PubMedID:19065646]

Tosiek et al. (2011). CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation. Journal of Immunology 186:6106  [PubMedID:21518973]

Tseng et al (2009) Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells. Regenerative Medicine 4:513 [PubMedID:19580370]

Uto et al. (2011). Comparative activity of biodegradable nanoparticles with aluminum adjuvants: Antigen uptake by dendritic cells and induction of immune response in mice. Immunology Letters 140:36[PubMedID:21693134]

Ventre et al (2012) Negative Regulation of NKG2D Expression by IL-4 in Memory CD8 T Cells. Journal of Immunology [PubMedID:22942430]

Verschelde, C. et al. (2006). Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection. Cell Death Differ. 13: 1213-1221. [PubMedID:16294210]

Vollers et al (2008) Class II major histocompatibility complex tetramer staining: progress, problems, and prospects. Immunology 123:305 [PubMedID:18251991]

Wickham, S. et al. (2005). Chemokine receptor deficiency is associated with increased chemokine expression in the peripheral and central nervous systems and increased resistance to herpetic encephalitis. J. NeuroImmunol. 162: 51-59. [PubMedID:15833359]

H-2Kb/SSIEFARL (HSV-1 gp B)

Yang, W. et al. (2007). Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML). Int. Immunol. 19: 1083-1093 [PubMedID:17660502]

Zelenay et al (2012) The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice Journal of Clinical Investigation [PubMedID:22505458]

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Model Antigen

Abdel-Motel, UM. et al. (2009). Mechanism for increased immunogenicity of vaccines that form in vivo immune complexes with the natural anti-Gal antibody. Vaccine. 27: 3072-3082. [PubMedID: 19428921]

H-2Kb/SIINFEKL (Ovalbumin)

Adriouch et al (2011) Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer. Frontiers In Microbiology 2:199 [PubMedID:22046170]

Amidi et al (2012) Induction of humoral and cellular immune responses by antigen-expressing immunostimulatory liposomes. Journal of Controlled Release [PubMedID:22940204]

Annoni, A. et al. (2009). In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance. Blood. 114: 5152-5161. [PubMedID: 19794140]

H-2Kd/HYLSTQSAL (eGFP)

Arnaboldi, PM. et al. (2009). Suppression of Th1 and Th17, but not Th2, responses in a CD8⁺ T cell-mediated model of oral tolerance. Mucosal Immunology. 2: 427-438. [PubMedID: 19571798]

H-2Kb/SIINFEKL (Ovalbumin)

Bahjat, K.S. et al. (2006). Cytosolic Entry Controls CD8 + T cell Potency During Bacterial Infection. Infect. Immun. 74: 6387-6397. [PubMedID: 16954391]

H-2Kb/SIINFEKL (Ovalbumin)

Bahjat, K. et al. (2009). Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria. PLos Pathogens. 5: e1000568 [PubMedID:19730694]

H-2Kb/SIINFEKL (Ovalbumin)

Binder, R.et al. (2005). Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8⁺ T cells. Nature Immunol. 6: 593-599. [PubMedID: 15864309]

H-2Kb/SIINFEKL (Ovalbumin)

Black et al (2012) Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo. Advanced Materials 24:3845 [PubMedID:22550019]

Bouma, G. et al. (2007). Impaired T cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood. 110: 4278-84 [PubMedID:17673604]

H-2Kb/SIINFEKL (Ovalbumin)

Bourquin, C. et al. (2007). Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T cell and IgG2a response. Blood 109: 2953-2960. [PubMedID:17132722]

H-2Kb/SIINFEKL (Ovalbumin)

Brinkman et al (2004) Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity. Letters in Drug Design and Discovery 1:137

Chapman et al (2012) Platelets Present Antigen in the Context of MHC Class I. Journal of Immunology 189:916[PubMedID:22706078]

Connolly, MK. et al. (2009). In liver fibrosis, dendritc cells govern hepatic inflammation in mice via TNF-a. J. Clin. Invest. 119: 3213-3225 [PubMedID:19855130]

H-2Kb/SIINFEKL (Ovalbumin)

Cuburu et al (2007) Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine 51:8598 [PubMedID:17996991]

Daniel, B. et al. (2010). A simple method to detect Toxoplasma Gondii-specific cytotoxic T cells in vivo. J. Imm. Methods, 355: 86-90 [PubMedID:20149795]

H-2Kb/SIINFEKL (Ovalbumin)

Diebold, SS. et al. (2008). Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines. Gene Therapy. 16: 359-366 [PubMedID: 19052633]

H-2Kb/SIINFEKL (Ovalbumin)

D’Orsogna et al (2012) Detection of allo-HLA cross-reactivity by virus-specific memory T-cell clones using single HLA-transfected K562 cells. Methods in Molecular Biology 882:339 [PubMedID:22665243]

Derbyshire et al (2011) Molecular mechanisms of induction of antigen-specific allograft tolerance by intranasal peptide administration. J. Immunol. 186:5719. [PubMedID:21490154]

Eby et al (2012) Polymer micelles with pyridyl disulfide-coupled antigen traffic through lymphatics and show enhanced cellular responses following immunization. Acta Biomaterialia [PubMedID:22698945]

Franck et al (2012) Immunological Tolerance to Muscle Autoantigens Involves Peripheral Deletion of Autoreactive CD8+ T Cells. PLoS One 7: e36444 [PubMedID:22570714]

Furmanski et al (2010) Peptide-Specific, TCR-α–Driven, Coreceptor-Independent Negative Selection in TCR α-Chain Transgenic Mice. J. Immunol. 184:650. [PubMedID:19995903]

Ga, M. et al. (2007). Single CX3CL1-Ig DNA administration enhances T cell priming in vivo. Vaccine 25: 4554-63. [PubMedID:[17493713]

H-2Kb/SIINFEKL (Ovalbumin)

Gerbitz et al (2012) Stromal Interferon-γ Signaling and Cross-Presentation Are Required to Eliminate Antigen-Loss Variants of B Cell Lymphomas in Mice.PLoS One 7:e34552 [PubMedID:22479645]

Goold, H. et al. (2011). Conventional Dendritic Cells Are Required for the Activation of Helper-Dependent CD8 T Cell Responses to a Model Antigen After Cutaneous Vaccination with Lentiviral Vectors. Journal of Immunology 186: 4565-72 [PubMedID: 21389256]

H-2Kb/SIINFEKL (Ovalbumin)

Gottrand et al (2012) Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice. Journal of Gene medicine [PubMedID:22228582]

Govers et al (2012) Magnetic-Activated Cell Sorting of TCR-engineered T cells using tCD34 as a gene marker, but not pMHC multimers, results in significant numbers of functional CD4 and CD8 T cells. Human Gene Therapy Methods [PubMedID:22746173]

Gutermuth, J. et al. (2009). Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V{alpha}2 down-regulation. J. Immunol. 183: 3130-3138.[PubMedID: 19675167]

H-2Kb/SIINFEKL (Ovalbumin)

Harms, JS. et al. (2009) Evaluation of recombinant invasive, non-pathogenic Eschericia coli as a vaccine vector against the intracellular pathogen, Brucella. Journal of Immune Based Therapies and Vaccines. 7: 1[PubMedID: 19126207]

H-2Kd/HYLSTQSAL (eGFP)

Hamasaki, T. et al. (2010).  Modulation of Gene Expression Related to Toll-Like Receptor Signaling in Dendritic Cells by Poly(g-Glutamic Acid) Nanoparticles.  Clinical and Vaccine Immunology 17: 748-276 [PubMedID: 20219877]

H-2Kb/SIINFEKL (Ovalbumin)

Heffernan et al (2011) In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines. Biomaterials 32:926 [PubMedID:20965561]

Hegazy et al (2012) Evaluation of Salmonella enterica Type III Secretion System Effector Proteins as Carriers for Heterologous Vaccine Antigens Infection and Immunity 80:1193 [PubMedID:22252866]

Hinterleitner et al (2012) Adoptive Transfer of siRNA Cblb-Silenced CD8+ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model. PLoS One 7:e44295 [PubMedID:22962608]

Howland et al (2008) Inducing Efficient Cross-priming Using Antigen-coated Yeast Particles. Journal of Immunotherapy 31:607 [PubMedID:18600183]

Hubert, S. et al. (2010).  Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.  Journal of Experimental Medicine [PubMedID: 20975043]

H-2Kb/SIINFEKL (Ovalbumin)

Johansson et al (2012) Intradermal Electroporation of Naked Replicon RNA Elicits Strong Immune Responses. PLoS One 7:e29732 [PubMedID:22238645]

Joshi et al (2012) Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation Journal of Leukocyte Biology epub [PubMedID:22331103]

H-2Kb/SIINFEKL (Ovalbumin)

Khan et al (2011) Regulation of T Cell Priming by Lymphoid Stroma. PLoS One 6: e26138[PubMedID:22110583]

Kuipers, H. et al. (2010) Dicer-Dependent MicroRNAs Control Maturation, Function, and Maintenance of Langerhans Cells In Vivo. J. Immunology. 185:400-409 . [PubMedID:20530258]

H-2Kb/SSIEFARL

Leggat, JA. et al. (2008). Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization. J. Allergy Clin. Immunol. 122: 1014-1021. [PubMedID:18804851]

H-2Kb/SIINFEKL (Ovalbumin)

Li et al. (2012). Dendritic cells sequester antigenic epitopes for prolonged periods in the absence of antigen-encoding genetic information. PNAS 109:17543. [PubMedID:23045695]

H-2Kb/SIINFEKL (Ovalbumin)

Luci, C. et al. (2006). Dendritic cell-mediated induction of mucosal cytotoxic responses following intravaginal immunization with the non-toxic B subunit of Cholera toxin. J. Immunol. 176: 2749-2757. [PubMedID:16493030]

H-2Kb/SIINFEKL (Ovalbumin)

Luckashenak, N. et al. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells control CD8⁺T cell tolerance in vivo. Immunity. 28: 521-532. [PubMedID:18387832]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SSIEFARL (HSV-gpB)
H-2Kb/TSYKFESV (vaccinia virus B8R)

Lund et al (2012) VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics Cell Reports epub

Martin-Orozco, et al. (2006). Programmed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens. J. Immunol. 177: 8291-8295. [PubMedID:17142723]

H-2Kb/SIINFEKL (Ovalbumin)

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H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SSYSYSSL

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H-2Kb/SIINFEKL (Ovalbumin)

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H-2Kb/SIINFEKL (Ovalbumin)

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H-2Kb/SIINFEKL (Ovalbumin)

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H-2Kb/SIINFEKL (Ovalbumin)

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H-2Kb/SIINFEKL (Ovalbumin)

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H-2Kb/SIINFEKL (Ovalbumin)
H-2Db/KAVYNFATC (LCMV GP1)

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H-2Kb/SIINFEKL (Ovalbumin)

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H-2Kb/SIINFEKL (Ovalbumin)

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H-2Kb/SIINFEKL (Ovalbumin)

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H-2Kb/SIINFEKL (Ovalbumin)

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The food you eat, the time you spend sleeping, or the exercise you do every day can all influence your immune system. Did you know that losing your sense of humor or feeling stressed out all the time could make you catch a cold a lot faster than other people with healthier lifestyles and better moods? It might sound far-fetched to most of you, but it’s been scientifically proven that the way we spend our days effects our health.  There are many things you can do to improve your immune response, and if you are currently lacking ideas, these next few lines should guide your steps.

Lost Your Sense Of Humor?

• Go to YouTube and search for the world’s best stand-up shows and plan a marathon. Grab your favorite snacks, slip into your most comfortable onesie or sweat suit and even consider having some friends over so you can watch the shows together.

• Don’t feel like watching a one-hour long stand-up performance? No worries, there are hundreds of funny full compilations with pets, babies, or regular people caught on tape doing funny things.

• Keep in mind laughter is one of the best natural medicines you could use for your overall well-being and immune system stimulations in particular, along with natural sunlight and good sleep. While you may not be able to laugh on command, keep in mind laughing is contagious. So if you have a friend who is always giggly and can make everyone laugh, give them a call.

• The Science of Laughter, an article by Robert Provine published in Psychology Today speaks about the 1962 outbreak of contagious giggles that occurred in a boarding school for girls in Tanzania. It all started with three girls who started laughing and could just not stop. The “laughter virus“ quickly contaminated 95 other students, which forced the principal to shut down the school. The girls were sent home, and they apparently spread the laughing epidemic to students in other schools in the country. It took more than two and a half years for those affected to stop giggling, and we are talking about close to one thousand “sufferers”.

Laughing can seriously curb your stress hormone levels and stimulate the grows of a particular type of white blood cells that are known to protect the body against infection.

Decompress With Games And Fun Activities

The good news is even the anticipation of an upcoming funny event can cause similar drops in the stress levels. Just think of this scenario: you join an online casino for real money, click on the first game of slots that crosses your eyes, hit the spin button and win $1,000. Just like that, in the split of a second. Can you feel yourself smiling right now, or at least feeling more relaxed?

While no one can guarantee you will win each and every time you will play the casino or place a sports bet, the anticipation of the potentially positive outcome of the game will definitely help you feel better. It’s nice to daydream about an exotic vacation or a luxury shopping spree, even though you don’t yet have the money for it.

So if you enjoy playing poker or roulette online, or you love fruit or football-themed slots, the internet is your free source of fun. You can literally find thousands of web casinos that offer countless free and real money games to cater to the needs and budgets of all types of players. Feeling a little overwhelmed? No worries, there are specialized platforms that assess all virtual casinos out there and recommend the best ones. GamblersBet.com is such a website where you can find top ratings on the best free games/spins, real money, mobile, or instant play venues that specialize in slots, poker, blackjack, or anything else you are interested in.

When you play a game you enjoy, you usually get lost in the game play, theme, storyline, or the play pretend. You become one with the characters on the screen or you exclusively focus on the outcome you would like to see. For example, a game of poker could keep you on your toes focusing on how to win a jackpot prize for hours on end. No stress, no negative thinking, no worries about your work projects due in a week. Just you, your smartphone or computer monitor, and the deck of cards in front of your eyes.

Fun activities in general and playing games in particular are excellent means of getting rid of some of the stress accumulated at work. Chronic stress is known to expose your body to a steady stream of hormones that will ultimately suppress and weaken your immune system. Dancing, drawing/painting, connecting with your friends and working out regularly are all excellent means of lowering your levels of stress.

 

More often than not, we tend to associate adrenaline with stress. While chronic stress has been proven to have bad effects on our overall health and immune response, it would appear that short adrenaline rushes are able to do the opposite. Want to learn more? Grab some coffee and keep reading.

What Is “Good” Stress?

Stress does not always have a detrimental effect on our bodies. And the same goes for a small rush of adrenaline. The adrenal glands release cortisol and adrenaline into the bloodstream and trigger the so-called adrenaline rush. Cortisol and adrenaline are the main stress hormones in our body. This means our minds and bodies become a lot more alert when these hormones reach the bloodstream. If the process is short, it can be a good thing. How exactly? Let’s find out:

• An adrenaline rush can help you be a lot more focused and to deal with cognitive tasks a lot faster. It’s similar to drinking coffee and it can help with your deadlines, so keep this in mind next time you need to finish something on time and you keep procrastinating.

• Plus, adrenaline rushes can help you stay alert and more aware of the things going on around you. When walking in the street, jogging by yourself, or just watching a TV series in the evening while home alone, a small adrenaline rush should help you be a lot more careful about what is going on around you. You should not let any distractions keep you from hearing or noticing when something is off or potentially dangerous. Someone trying to sneak into your home might be easily ignored when your mind is wandering in a hundred different places at once. But having some cortisol and adrenaline in your blood could help you immediately become aware of all the hazards and handle them a lot better.

• Your vision is also likely to improve during an adrenaline spike, especially when reacting to a perceived threat. Your pupils will dilate as a natural response, which will let more light in and make you see better. You should be able to see someone sneaking in your back yard late at night and call the police straight away.

Adrenaline Makes Other Experiences Better

Watching a scary movie or playing and winning the casino will definitely make you feel more vigilant and excited many hours after the movie or gambling sessions is over. The process was even given a scientific name – excitation transfer process. It refers to the intensified state of well-being or fright experienced after the triggering factor was enabled. For example, watching a horror movie where someone breaks into a home and kidnaps the people there will likely make you feel the need to double check your door and window locks, and see if your alarm is working fine.

If you have any surveillance cameras installed in the house and/or the yard/porch, chances are you will feel the need to look at the images and make sure everything is alright. If you do not already have an alarm system installed, or you need to fix or replace your old locks, you should get in touch with a home locksmith. Services like this one https://get-locksmith.com/emergency-locksmith for homes can help you immediately replace your broken or vulnerable locks and choose more reliable solutions. If your windows do not already have locks with sensors or safety bars on them, or your front door does not have a peephole on it, a lock technician can also fix this.

Living in a safer home that is fully protected against potential intruders and threats will make you feel more relaxed and keep your stress levels at bay.

Adrenaline Stimulates The Immune System

Small doses of adrenaline that reach our bodies will give our immune system a boost. This can help us fight off infections a lot easier, even if it is on a temporary basis.

Plus, adrenaline can turn us into genuine Hulks for a few minutes. Just think of the times when a skinny Mom manages to rescue her child from beneath a massive closet that has fallen over them. During an adrenaline rush, you could even pick a rock and break a side window on your car to reach your child or pet that may have remained locked in during an accidental lockout. However, you are recommended to call 911 or an emergency locksmith and avoid any additional problems or injuries, unless you are in a dramatic situation where every second counts.