ProImmune Pentamer Citations | Infectious Disease

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Infectious Disease Publications citing the use of ProImmune Pentamers

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Chlamydia

Influenza

Listeria

Malaria

Mycobacterium Tuberculosis

Trypanosoma Cruzi

 

Chlamydia

Holland et al (2006) The Frequency of Chlamydia trachomatis Major Outer Membrane Protein-Specific CD8+ T Lymphocytes in Active Trachoma Is Associated with Current Ocular Infection. Infection and Immunity 74:1565 [PubMedID:16495527]

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Influenza

Afonso, G., et al. (2010) Critical parameters in blood processing for T-cell assays: Validation on ELISpot and tetramer platforms.  Journal of Immunological Methods 359: 28-36 [PubMedID: 20641145]

A*02:01/GILGFVFTL (Influenza A MP)

Avetisyan, G. et al. (2008). Evaluation of immune responses to seasonal influenza vaccination in healthy volunteers and in patients after stem cell transplantation. Transplantation. 86: 257-263 [PubMedID: 18645488]

A*01:01/ILRGSVAHK (Influenza NP)
A*02:01/GILGFVFTL (Influenza MP)
A*03:01/CTELKLSDY (Inlfuenza NP)

Bannard, O. et al. (2009) Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science. 323: 505-509. [PubMedID: 19164749]

H-2Db/ASNENMETM (Influenza NP PR8)

Bengsch, B. et al. (2007). Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J. Virology. 81: 945-953. [PubMedID: [17079288]

A*02:01/GILGFVFTL (Influenza A MP)

Betts et al (2012)Influenza A virus infection results in a robust, antigen-responsive, and widely disseminated Foxp3+ regulatory T cell response.  Journal of Virology 86:2817 [PubMedID:22205730]

Bohana-Kashtan, O. et al (2009). Selective reduction of graft-versus-host disease-mediating human T cells by ex vivo treatment with soluble Fas ligand. J. Immunol. 183: 696-705 [PubMedID: 19535642]

A*02:01/GILGFVFTL (Influenza MP)
B*07:02/RPPIFIRRL (EBV EBNA-3)

Bohnenkamp et al (2007) Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type I responses. Cellular Immunology 247:72 [PubMedID:17927969]

Currie, AJ. et al. (2009) Dual Control of Antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: Regulation and counterregulation. J. Immunol. 183: 7898-7908. [PubMedID: 20007574]

H-2Kd/IYSTVASSL (Influenza HA)

DiNapoli, JM. et al. (2008). Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection. Virology Journal. 5: 105 [PubMedID: 18816384]

H-2Kd/TYQRTRALV (Influenza NP)
H-2Kd/SYIGSINNI (RSV M2)

Fiore, F. et al. (2007). Enhanced ability of dendritic cells to stimulate innate and adaptive immunity upon short-term incubation with zoledronic acid. Blood 110: 921-7. [PubMedID: 17403919]

Duvvuri, V. R. et al (2013) T cell memory to evolutionarily conserved and shared hemagglutinin epitopes of H1N1 viruses: a pilot scale study. BMC Infectious Diseases 13: 204-216 [PubMedID: 23641949]

Ge et al (2012) NK Cells Regulate CD8+ T Cell Priming and Dendritic Cell Migration during Influenza A Infection by IFN-γ and Perforin-Dependent Mechanisms. Journal of Immunology 189:2099 [PubMedID:22869906]

Hatta et al (2010) Viral replication rate regulates clinical outcome and CD8 T cell responses during highly pathogenic H5N1 influenza virus infection in mice. PLoS Pathogens 6: e1001139 [PubMedID:20949022]

Harris et al (2011) Intramuscular immunization of mice with live influenza virus is more immunogenic and offers greater protection than immunization with inactivated virus.  Virology Journal. 8:251.  [PubMedID: 21600020]

Hoelscher, M.A. et al. (2007). New pre-pandemic influenza vaccines: an egg- and adjuvant-independent human adenoviral vector strategy induces long-lasting protective immune responses in mice. Clin. Pharmacol. Ther. 82: 665-71. [PubMedID: 17957181]

H-2Kd/IYSTVASSL (Influenza A HA)
H-2Kd/TYQRTRALV (Influenza A (PR8) NP)

Hoelscher, M.A. et al. (2006). Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice. The Lancet 367: 475-481. [PubMedID: 16473124]

H2Db/SSLENFRAYV (Influenza A (PR8) Polymerase acidic protein 224-233)

Ivanov S. et al (2013) Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection. J. Virology epub [PubMedID:23596287]

Kohlmeier, J. et al. (2010). Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways during Respiratory Virus Challenge. Immunity 33:96-105. [PubMedID:20637658]

A*02:01/GILGFVFTL (Influenza A MP)

Knuschke, T. et al (2013) Immunization with biodegradable nanoparticles efficiently induces cellular immunity and protects against influenza virus infection. J. Immunol. Epub ahead of print [PubMedID:23667109]

H-2Kd/IYSTVASSL (Influenza A HA 533-541)

Liu et al (2012) Impaired production of TNF-α by dendritic cells of older adults leads to a lower CD8+ T cell response against influenza. Vaccine. [PubMedID:22230585]

Liu, Y. et al. (2006). Regulated Expression of Fc{gamma}R in Human Dendritic Cells Controls Cross-Presentation of Antigen-Antibody Complexes. J. Immunol. 177: 8440-8447. [PubMedID:17142741]

A*02:01/GILGFVFTL (Influenza A MP)

Ljungman, P. et al. (2008). Influenza vaccination in hematopoietic SCT recipients. Bone Marrow Transplantation. 42: 637-641. [PubMedID: 18724396]

Magini, D. et al. (2016). Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge. PLoS One. 11(8). [PubMedID: 27525409]

Mostböck, S. et al. (2007). Enhanced levels of costimulation lead to reduced effector/memory CD8+ T cell functionality. J. Immunol. 179: 3524-34. [PubMedID: 17785786]

H-2Db/ASNENMDAM (Flu NP68)

Mostböck, S. et al. (2008). IL-2/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8+ T cell responses and increases the ratio of effector/memory CD8+ T cells to regulatory T cells. J. Immunol. 180: 5118-5129. [PubMedID: 18354238]

H-2Db/ASNENMDAM (Flu NP68)

Mount et al (2010) Mouse Models of Viral Infection: Influenza Infection in the Lung. Methods in Molecular Biology 595:299 [PubMedID:19941121]

Muñoz-Fontela et al (2011) p53 Serves as a Host Antiviral Factor That Enhances Innate and Adaptive Immune Responses to Influenza A Virus. Journal of Immunology 187:6428 [PubMedID:22105999]

Nembrini et al (2011) Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination. PNAS 108:E989 [PubMedID: 21969597]

Obermann, S. et al. (2007). Peptide b-microglobulin-major histocompatibility complex expressing cells are potent antigen-presenting cells that can generate specific T cells. Immunology 122: 90-7. [PubMedID: 17472719]

A*02:01/GILGFVFTL (Flu MI)
A*02:01/SLLMWITQV (NY-ESO-1)

Paget et al. (2011). Potential role of invariant NKT cells in the control of pulmonary inflammation and CD8+ T cell response during acute influenza A virus H3N2 pneumonia. Journal of Immunology 186:5590 [PubMedID: 21490153]

Pandey et al (2012) Impact of Preexisting Adenovirus Vector Immunity on Immunogenicity and Protection Conferred with an Adenovirus-Based H5N1 Influenza Vaccine. PLoS One 7:e33428 [PubMedID:22432020]

Price, GE. et al. (2009). Vaccination focusing immunity of conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses. Vaccine. 27: 6512-6521 [PubMedID: 19729082]

H-2Kd/TYQRTRALV (Influenza A NP)

Richards, K. et al. (2011). The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity. Immunology. 27: 6512-6521 [PubMedID: 20889549]

Ross, TM. et al. A trivalent virus-like particle vaccine elicits protective immune responses against seasonal influenza strains in mice and ferrets. PLos One. 4: e6032. [PubMedID: 19554101]

H-2Kd/IYSTVASSL (Influenza NP)
H-2Kd/TYQRTRALV (Infleunza NP)

Sawai, T. et al. (2008). Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin. Immunology 124: 155-165. [PubMedID: 18205793]

H-2Db/ASNENMDAM (Flu NP)

Saxena, A. et al. (2008). Cutting Edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. J. Immunol. 181: 1617-1621 [PubMedID: 18641296]

H-2Kd/IYSTVASSL (Influenza A HA)

Siegel et al (2012) Factors That Determine the Antiviral Efficacy of HCV-Specific CD8+ T Cells Ex Vivo. Gastroenterology. epub [PubMedID:23142136]

A*02:01/GILGFVFTL (Influenza A MP 58-66)

Singh, N. et al. (2008). Bovine adenoviral vector-based H5N1 influenza vaccine overcomes exceptionally high levels of pre-existing immunity against human adenovirus. Mol. Ther. 16: 965-71. [PubMedID:18301400]

H-2Kd/IYSTVASSL (Influenza HA)

Shinya et al (2011) The TLR4-TRIF Pathway Protects against H5N1 Influenza Virus Infection. Journal of Virology 86:19 [PubMedID:22031950]

Skevaki, C. et al (2017) Influenza-derived peptides cross-react with allergens and provide asthma protection. Journal of Allergy and Clinical Immunology. [Epub ahead of print] [PubMedID:29132960]

H-2Kd/IYSTVASSL (Influenza HA)

Smed-Sörensen et al (2012) Influenza A Virus Infection of Human Primary Dendritic Cells Impairs Their Ability to Cross-Present Antigen to CD8 T Cells PloS Pathogens 8:e1002572 [PubMedID:22412374]

Suneetha, PV. et al. (2009). Effect of peptide pools on effector functions of antigen-specific CD8+ T cells. J Immunol. Methods 342: 33-48. [PubMedID:19135447]

A*02:01/GILGFVFTL (Influenza MP)
A*02:01/NLVPMVATV (CMV pp65)
A*02:01/GLCTLVAML (EBV BMLF-1)
A*02:01/CINGVCWTV (HCV NS3)

Takeuchi, A. et al. (2009). CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. J. Immunol. 183: 4220-4228 [PubMedID:19752223]

H-2Db/ASNENMDAM (Influenza NP)

Tang et al (2010) Hemagglutinin Displayed Baculovirus Protects Against Highly Pathogenic Influenza. Vaccine 28:6821 [PubMedID:20727393]

Taylor et al (2013) Protein Energy Malnutrition Decreases Immunity and Increases Susceptibility to Influenza Infection In Mice. J. Infectious Disease. 186 [PubMedID:22949306]

H2Db/ASNENMETM (Influenza A (PR8) NP 366-374)

Toapanta et al (2009) Impaired immune responses in the lungs of aged mice following influenza infection. Respiratory Research 10:112 [PubMedID:19922665]

Vemula, S. V. et al (2013) Broadly protective adenovirus-based multivalent vaccines against highly pathogenic avian influenza viruses for pandemic preparedness. PLoS One 8(4):e62496 [PubMedID: TBC]

H-2Kd/IYSTVASSL (Influenza A HA 533-541)
H-2Kd/TYQRTRALV (Influenza A (PR8) NP 147-155)

Vogt, A. et al. (2008). Transcutaneous anti-influenza vaccination promotes both CD4 and CD8 T cell immune responses in humans. J. Immunol. 180: 1482-9. [PubMedID:18209043]

A*02:01/GILGFVFTL (Influenza MP)

Waeckerle-Men, Y. et al. (2005). Dendritic cells generated from patients with androgen independent prostate cancer are not impaired in migration and T cell stimulation. The Prostate 64: 323-331. [PubMedID:15754347

A*02:01/GILGFVFTL (Influenza A MP)

Westendorf, A.M. et al. (2006). Autoimmune-mediated intestinal inflammation-impact and regulation of antigen-specific CD8+ T cells. Gastroenterology 131: 510-524. [PubMedID:16890605]

H-2Kd/IYSTVASSL (Influenza A HA)

Xie, D. and McElhaney, J. (2007). Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes. Mech Ageing Dev. 128: 392-400. [PubMedID:17570460]

A*02:01/GILGFVFTL (Flu MP)

Zaharoff et al (2007) Chitosan solution enhances the immunoadjuvant properties of GM-CSF. Vaccine 25:8673 [PubMedID:18037196]

Zhang, X. et al. (2008). Treatment of pulmonary metastatic tumors in mice using lentiviral vector-engineered stem cells. Cancer Gene Ther. 15: 73-84. [PubMedID:18084244]

H-2Kd/IYSTVASSL (Flu HA)

Zhou et al. (2012). The functional CD8 T cell memory recall repertoire responding to the influenza A M158–66 epitope is polyclonal and shows a complex clonotype distribution. Human Immunol. epub [PubMedID: TBC]

A*02:01/GILGFVFTL (Influenza A MP 58-66)

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Listeria

Bahjat, K. et al. (2009). Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria. PLos Pathogens. 5: e1000568 [PubMedID:19730694]

H-2Kb/SIINFEKL (Ovalbumin)

Edelson et al. (2011). CD8α+ Dendritic Cells Are an Obligate Cellular Entry Point for Productive Infection by Listeria monocytogenes.  Immunity 35:236  [PubMedID:21867927]

Gurung, P. et al. (2009). Chronic ethanol induces inhibition of antigen-specific CD8+ but not CD4+ immunodominant T cell responses following Listeria monocytogenes inoculation. J. Leukoc. Biol.85: 34-43 [PubMedID: 18820175]

H-2Kd/GYKDGNEYI (Listeriolysin O)

Husseiny, MI. and Hensel, M. (2009) Evaluation of Salmonella live vaccines with chromosomal expression cassettes for translocated fusion proteins. Vaccine 27: 3780-3787 [PubMedID: 19464562]

H-2Kd/GYKDGNEYI (Listeriolysin O)

Lee et al (2009) Expression and Function of TLR2 on CD4 Versus CD8 T Cells. Immune Network 9:127 [PubMedID:20157599]

Nitcheu-Tefit, J. et al. (2007). Listeriolysin O expressed in a bacterial vaccine suppresses CD4+ CD25high regulatory T cell function in vivo. J. Immunol. 179: 1532-1541. [PubMedID:17641019]

H-2Kb/SIINFEKL (Ovalbumin)

Sakowicz-Burkiewicz, M. et al. (2008) Protein kinase C-{theta} critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis. J. Immunol. 180: 5601-5612. [PubMedID:18390745]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Db/KAVYNFATC (LMCV gp33)

Seo, S.K. et al. (2007). Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection. Immunology 123: 90-9. [PubMedID: 17971153]

H-2Kd/GYKDGNEYI (Listeriolysin O)

Tam et al (2009) MyD88 and interferon-α/β are differentially required for dendritic cell maturation but dispensable for development of protective memory against Listeria. Immunology 128:429 [PubMedID:20067542]

Xu, X. et al (2010) Efficacy of Intracellular Activated Promoters for Generation  of Salmonella-Based Vaccines.  Infection and Immunity Nov 2010: 4828-4838 [PubMedID: 20732994]

H-2Kd/GYKDGNEYI (Listeriolysin O)

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Malaria

Bisseye et al (2011) An engineered Plasmodium falciparum C-terminal 19-kilodalton merozoite surface protein 1 vaccine candidate induces high levels of interferon-gamma production associated with cellular immune responses to specific peptide sequences in Gambian adults naturally exposed to malaria. Clinical & Experimental Immunology 166:366 [PubMedID: 22059995]

Espinoza Mora, MdR et al (2014) Depletion of Regulatory T Cells Augments a Vaccine-Induced T Effector Cell Response against the Liver-Stage of Malaria but Fails to Increase Memory. PLoS ONE. 9(8): e104627. [PubMedID: 25115805]

Ferriera et al. (2011). Sickle hemoglobin confers tolerance to Plasmodium infection. Cell 145:398 [PubMedID: 21529713]

Kolbaum et al (2012) Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration. European Journal of Immunology 42:890 [PubMedID:22161305]

Rodriguez, A. et al. (2008). Impact of recombinant Ad35 priming versus boosting of a Plasmodium falciparum protein: characterization of T- and B-cell responses to the liver stage antigen 1 (LSA-1). Infect Immun. 76: 1709-1718. [PubMedID: 18212075]

H-2Kd/YYIPHQSSL (LSA Plasmodium falciparum)

Swanson, P. et al. (2016) CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature. PLoS Pathog. 12(12). [PubMedID:27907215]

Tartz et al. (2013). Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8+ memory T cells. Eur. J. Immunol. epub [PubMedID: 23229763]

H-2Kd/SYIPSAEKI (Plasmodium berghei CSP 252-260)

Tartz, S. et al. (2006). Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria. Infect. Immun. 74: 2277-2285. [PubMedID: 16552058]

H-2Kd/SYIPSAEKI (Plasmodium berghei CSP)

Tartz, S. et al. (2008). Complete protection against P.berghei malaria upon heterologous prime/boost immunization against circumsporozite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid. Vaccine. 26: 5935-5943. [PubMedID: 18804138]

H-2Kd/SYIPSAEKI (CSP)

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Mycobacterium Tuberculosis

Begum, D. et al. (2009). Accelerated induction of mycobacterial antigen-specific CD8+ T cells in the Mycobacterium tuberculosis-infected lung by subcutaneous vaccination with Mycobacterium bovis bacille Calmette-Guerin. Immunology. 128: 556-563. [PubMedID: 19930045]

H-2Db/GAPINSATAM (Mycobacterium Tuberculosis 32a)

Billeskov, R. et al. (2007). Induction of CD8 T Cells against a novel epitope in TB10.4: Correlation with mycobacterial virulence and the presence of a functional region of Difference-1. J. Immunol. 179: 3973-3981 [PubMedID:17785835]

H-2Kb/IMYNYPAM (Mycobacterium tuberculosis M.tb 10.4)

Caccamo, N. et al. (2006). Phenotypical and functional analysis of memory and effector human CD8 T cells specific for mycobacterial antigens. J. Immunol. 177: 1780-1785. [PubMedID: 16849488]

A*02:01/GLPVEYLQV (Mycobacterium bovis antigen 85-A)

Divangahi et al (2010) Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nature Immunology 751:758 [PubMedID:20622882]

H-2Db/ASNENMETM Influenza A (PR8) NP 366-374

Dong et al Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells. Mucosal Immunol. 6(3): 522-534. [PubMedID:23032790]

Hoang, TTKT. et al. (2009). Distinct differences in the expansion and phenotype of TB10-4 specific CD8 and CD4 T cells after infection with Mycobacterium tuberculosis. PLoS ONE. 4: e5928 [PubMedID: 19529765]

H-2Kb/IMYNYPAM (Mycobacterium tuberculosis M.tb 10.4)

Jaron, B. et al. (2008). Effect of attenuation of Treg during BCG immunization on anti-mycobacterial Th1 responses and protection against Mycobacterium tuberculosis. PLoS ONE 3: e2833 [PubMedID: 18665224]

H-2Kd/VYAGAMSGL (TB10.3/4:208-28)

Radosevic, K. et al. (2007). Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains (H-2d vs. H-2b): CD4 and CD8 T-cell epitope mapping and role of gamma interferon. Infect. Immun. 75: 4105-4115. [PubMedID:17526747]

Spencer et al (2012) Fusion of the Mycobacterium tuberculosis Antigen 85A to an Oligomerization Domain Enhances Its Immunogenicity in Both Mice and Non-Human Primates. PLoS One 7:e33555 [PubMedID:22470455]

Wang et al. (2011). Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis. Journal of Infection. 62:292. [PubMedID:21382414]

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Trypanosoma Cruzi

de Alencar, BCG. et al. (2009). Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination. Infection & Immunity. 77: 4383-4395. [PubMedID: 1965871]

H-2Kb/VNHRFTLV (Trypanosoma cruzi ASP-2)

Ono et al (2012) Actively induced antigen-specific CD8+ T cells by epitope-bearing parasite pre-infection but not prime/boost virus vector vaccination could ameliorate the course of Plasmodium yoelii blood-stage infection. Vaccine 30:6270 [PubMedID:22902783]

Silverio et al (2012) CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy. PLoS Path. 8:e1002645. [PubMedID:22532799]

H2Kb/VNHRFTLV (Trypanosoma cruzi ASP-2 553-560)

Takayama, E. et al. (2010) Quantitative and qualitative features of heterologous virus-vector-induced antigen-specific CD8+ T cells against  Trypanosoma cruzi infection. International Journal for Parasitology. 40:1549. [PubMedID: 20620143]

H-2Kb/VNHRFTLV (Trypanosoma cruzi ASP-2)

Tzelepis, F. et al. (2008) Infection with Trypanosoma cruzi restricts the repertoire of parasite-specific CD8+ T cells leading to immunodominance. J Immunol. 180: 1737-1748. [PubMedID: 18209071]

H-2Kb/VNHRFTLV (Trypanosoma cruzi ASP-2)

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