Customer publications citing the use of Pentamers in immunity research | ProImmune

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Immunity Research citing the use of ProImmune Pentamers

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Allergy

Autoimmunity

Minor Histocompatibility Antigen (miHAg)

Other

Model Antigen

 

 

Allergy

Woodfolk J.A.  (2007) T-cell responses to allergens. Journal of Allergy and Clinical Immunology 119:280 [PubMedID:17291848]

 

Autoimmunity

Ankathatti Munegowda et al  (2011) A Distinct Role of CD4(+) Th17- and Th17-Stimulated CD8(+) CTL in the Pathogenesis of Type 1 Diabetes and Experimental Autoimmune Encephalomyelitis. J Clin Immunol. [PubMedID: 21674137]

Arce F. et al  (2011) Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis. Arthritis Rheum. 63(1):84-95 [PubMedID:20967853]

Crampton et al (2012) Ifih1 Gene Dose Effect Reveals MDA5-Mediated Chronic Type I IFN Gene Signature, Viral Resistance, and Accelerated Autoimmunity.  Journal of Immunology 188:1451 [PubMedID:22205024]

Engkilde, K. et al (2011) Prevention of type 1 diabetes by inducing subclinical dermatitis on a small area Diabetes and Metabolism Research and Reviews. 27: 954

Fierabracci, A. (2011) The potential of multimer technologies in type 1 diabetes prediction strategies. Diabetes and Metabolism Research and Reviews. 27: 216-229 [PubMedID: 21309048]

Freed et al (2011) Association of the HLA–DRB1 epitope LA67, 74 with rheumatoid arthritis and citrullinated vimentin binding. Arthritis and Rheumatism 63:3733 [PubMedID:22094856]

Giuliani et al (2009) Detection of GAD65 Autoreactive T-Cells by HLA Class I Tetramers in Type 1 Diabetic Patients. Journal of Biomedicine and Biotechnology 2009:576219 [PubMedID:20029631]

Ha et al (2010) Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity. Journal of Clinical Investigation 120:4273 [PubMedID:21084750]

Ohnmacht, C. et al. (2009). Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J. Exp. Med. 206: 549-559 [PubMedID: 19237601]

H-2Kb/SIINFEKL (Ovalbumin)

Mallone, R. et al (2011) Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report—HLA Class I Tetramer Validation Initiative Diabetes and Metabolism Research and Reviews. 27: 720 [PubMedID:22069251]

Matthis et al (2012) T Cell Autoreactivity in the Transplant Milieu. American J. Transplant. 12:1674 [PubMedID:22642536]

Monti, P. et al. (2008) Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J. Clin. Invest. 118: 1806-1814 [PubMedID: 18431516]

A*02:01/VMNILLQYV (GAD 65)
A*02:01/GILGFVFTL (Flu-A MP)
A*02:01/SLYNTVATL (HIV gag p17)

Monti, P. et al. (2007). Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J. Immunol. 179: 5785-92. [PubMedID: 17947651].

A*02:01/VMNILLQYV (GAD 65)
A*02:01/GILGFVFTL (Flu-A MP)
A*02:01/SLYNTVATL (HIV gag p17)

Munoz-Suano et al (2011) Regulatory T cells protect from autoimmune arthritis during pregnancy. Journal of Autoimmunity 38:J103 [PubMedID:22004905]

Van Belle et al. (2011). Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model. J. Immunol. 187: 2915 [PubMedID:21832162].

Van Belle et al (2012) Interleukin-21 Receptor-Mediated Signals Control Autoreactive T Cell Infiltration in Pancreatic Islets Immunity 36:1060 [PubMedID:22579473]

Van Belle et al (2012) NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes. Journal of Autoimmunity [PubMedID:22944096]

Weyd, H. et al (2013) Annexin A1 on the surface of early apoptotic cells suppresses CD8+ T cell immunity. PLoS One 8(4):e62449 [PubMedID:23638088]

H-2Kb/SIINFEKL (Ovalbumin 257-264)

Zierden et al (2010) Effects and Regulation of Autoreactive CD8+ T Cells in a Transgenic Mouse Model of Autoimmune Hepatitis Gastroenterology 139:975 [PubMedID:20639127]

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Minor Histocompatibility Antigen (MiHAg)

Baldwin, T. et al. (2005). The timing of TCRa expression critically influences T cell development and selection. J Exp Med. 202: 111-121. [PubMedID: 15998791

H-2Db/KCSRNRQYL (miHAg smcy)

D'Asaro, M. et al. (2006). Increase of CCR7(-) CD45RA(+) CD8 T cells (T(EMRA)) in chronic graft-versus-host disease. Leukemia 20: 545-547. [PubMedID:16408100]

A*02:01/FIDSYICQV (miHAg SMCY)

Fan, Y. et al. (2009). Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J. 28: 2812-2824. [PubMedID: 19680229]

H-2Db/WMHHNMDLI (miHAg UTY)

Flutter, B. et al. (2010). Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.Journal of Clinical Investigation[PubMedID: 20978352]

H-2Kb/LTFNYRNL(miHAg)

Eiz-Vesper, B. et al. (2006). Tetanus toxoid provides efficient T-cell help for the induction of HA-1(H) cytotoxic T cells. Transfusion 46: 1210-1220. [PubMedID:16836569]

Hu, Q. et al. (2009). Bim-mediated Apoptosis in not necessary for thymic negative selection to ubiquitous self-antigens. J. Immunol. 183: 7761-7767. [PubMedID: 19933852]

H-2Db/KCSRNRQYL (miAg SMCY)

Kwun et al (2011) Primary Vascularization of the Graft Determines the Immunodominance of Murine Minor H Antigens during Organ Transplantation. Journal of Immunology epub [PubMedID: 21900176]

Kwun, J. et al. (2007) Altered distribution of H60 minor H Antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- Mouse Recipients. J Immunol. 179: 8016-8025. [PubMedID: 18056341]

H-2Kb/SGIVYIHL (H4b)
H-2Kb/KAPDNRDTL (H7b)
H-2Kb/SSVIGVWYL (H13b)
H-2Kb/ILENFPRL (H28)

Michelini, R. et al. (2010) Concomitant Tumor and Minor Histocompatibility Antigen-Specific Immunity Initiate Rejection and Maintain Remission from Established Spontaneous Solid Tumours. Cancer Research. 70(9): 3505-14. [PubMedID: 20388780]

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Other

Allen S., et al (2011) The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus type 1.  Journal of Virology. 85: 4814 [PubMedID: 21307196]

H-2Kb/SSIEFARL (HSV-1 gp B)

Argani et al (2011) Characterization of herpes simplex virus 1 strains as platforms for the development of oncolytic viruses against liver cancer. Liver International 31: 1542 [PubMedID: 22093330] 

Attig et al (2011) A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols. Journal of Translational Medicine 9:108 [PubMedID:21745365]

Baschuk, N. et al. (2007). Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice. Cancer Immunol. Immunother. 56: 1625-36. [PubMedID: 17431618]

H-2Kb/VVYDFLKL (SV40 tag)

Bernardo et al (2011) Phenotypic and functional evaluation of CD3+CD4-CD8- T cells in human CD8 immunodeficiency. Haematologica 96:1195 [PubMedID:21546492]

Cantisan et al (2010) CD45RA expression on HCMV-specific effector memory CD8+ T cells is associated with the duration and intensity of HCMV replication after transplantation. Clinical Immunology 137:81 [PubMedID:20674505]

Carr, D.J.J. et al. (2006). The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection. Immunology 118: 520-526. [PubMedID:16895559]

H-2Kb/SSIEFARL (HSV-1 gp B)

Castella et al. (2011). Immune Modulation by Zoledronic Acid in Human Myeloma: An Advantageous Cross Talk between Vg9Vδ2 T Cells, αβ CD8+ T Cells, Regulatory T Cells, and Dendritic Cells. Journal of Immunology epub. [PubMedID:21753152]

Cento et al (2011) Intratype Variation of HPV 31 and 58 in Italian women with abnormal cervical cytology. J Med Virol. 83:1752 [PubMedID:21837791]

Chang (2011) Lentiviral Vector Transduction of Dendritic Cells for Novel Vaccine Strategies. Methods in Molecular Biology 614:161 [PubMedID:20225043]

Chappert et al (2010) Antigen-specific Treg impair CD8+ T-cell priming by blocking early T-cell expansion. European Journal of Immunology 40:339 [PubMedID:19877007]

Chatterjee et al (2012) Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells  Blood [PubMedID:22791285]

Cheent et al (2013) Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. PNAS. 110:42 [PubMedID: 24082146]

E*01:01 / VMAPRTLIL (HLA-E)

Circosta et al (2009) T Cell Receptor (TCR) Gene Transfer with Lentiviral Vectors Allows Efficient Redirection of Tumor Specificity in Naive and Memory T Cells Without Prior Stimulation of Endogenous TC. Human Gene Therapy 20:1576 [PubMedID:19678763]

Claassen, EA. et al. (2007). Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity. Virology. 368: 17-25. [PubMedID: 17632195]

H-2Kd/CYLTDRARI (PVM G)

Claassen, E.A. (2005). Activation and inactivation of antiviral CD8 T cell responses during murine pneumovirus infection. J. Immunol. 175: 6597-6604. [PubMedID:16272314]

H-2Kd/CYLTDRARI (PVM G)

Davis et al (2011) Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis. Nature Reviews Immunology 11:551.  [PubMedID:21760610]

Degauque et al. (2011)  The Blood of Healthy Individuals Exhibits CD8 T Cells with a Highly Altered TCR Vb Repertoire but with an Unmodified Phenotype. PLoS One 6: e21240 [PubMedID: 21738624]

Dervovic et al. (2012) Comparative and Functional Evaluation of In Vitro Generated to Ex Vivo CD8 T Cells. J. Immunol. 189:3411 [PubMedID: 22925927]

Duewell et al. (2011) ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells. Journal of Immunology 187:55 [PubMedID: 21613613]

Dudek et al. (2011) Evidence for differences in immunologic and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa. Journal of Infectious Diseases 203:1434  [PubMedID: 21498376]

Dudek, T. et al. (2008) Disruption of the UL41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes. Virology. 372: 165-175 [PubMedID: 18006033]

H-2Kb/SSIEFARL (HSV gpB)

Duplan, V. et al. (2007). Tracking antigen-specific CD8+ T cells in the rat using MHC class I multimers. J. Immunol. Methods 320: 30-39. [PubMedID:17223126]

First custom Pentamer synthesized for rat MHC

Edelson et al (2010) Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. Journal of Experimental Medicine 207:823 [PubMedID:20351058]

Fallarino, F. et al. (2006). The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor z chain and induce a regulatory phenotype in naive T cells. J. Immunol. 176: 6752-6761. [PubMedID:16709834]

Flies et al. (2011) Immunoglobulin light chain, Blimp-1 and cytochrome P4501B1 peptides as potential vaccines for AL amyloidosis.  Immunology and Cell Biology epub [PubMedID:21894172]

Fleissner et al (2010) Local Induction of Immunosuppressive CD8+ T Cells in the Gut-Associated Lymphoid Tissues . PLoS One 5:e15373 [PubMedID:20975955]

Franck et al (2012) Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactive CD8+T cells. PloS One 7:5 [PubMedID: 22570714]

Kb/RGYVYQGL (VSV)

Fuertes, M. et al (2011) Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells. Journal of Experimental Medicine. 208:2005  [PubMedID:21930765]

Ghio et al (2012) OxLDL- and HSP-60 antigen-specific CD8(+) T lymphocytes are detectable in the peripheral blood of patients suffering from coronary artery disease. Clinical and Experimental Medicine  [PubMedID:22886609]

Guo et al (2009) Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigenB-cell-based cellular vaccine Gene Therapy 16:1300 [PubMedID:19641529]

Guo et al (2012) Deletion of FoxN1 in the Thymic Medullary Epithelium Reduces Peripheral T Cell Responses to Infection and Mimics Changes of Aging PLoS One 7:e34681 [PubMedID:22514652]

Han et al (2010) Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells from hematopoietic stem cells. Journal of Immune Based Therapies and Vaccines 8:8 [PubMedID:21106069]

Han et al (2009) Immunity of Lentiviral Vector-Modified Dendritic Cells. Methods in Molecular Biology 542:245 [PubMedID:19565906]

Hervouet, C. et al. (2010). Langerhans Cells Prime IL-17-Producing T cells and Dampten Genital Cytotoxic Responses following Mucosal Immunization. Journal of Immunology. 184: 4842-4851. [PubMedID:20351191]

Himoudi et al (2012) Human gamma delta T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells Journal of Immunology 188:1708 [PubMedID:22250090]

Hoppstädter et al (2012) Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation. European Journal of Immunology 42:1282 [PubMedID:22539300]

Huang et al (2011) Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule. Nature Immunology 12:1086 [PubMedID:21964609]

Isa, A. et al. (2005). Prolonged activation of virus-specific CD8+ T cells after acute B19 infection. PLoS Med. 2: e343. (Epub) [PubMedID: 16253012]

Jakel, S. et al. (2009). Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis. Am. J. Pathol. 175: 510-518. [PubMedID:19590042]

H-2Db/FRHNNVTLM (VP2)
H-2Kb/TLPAFSTL (P3D)

Jelinek I., et al (2011) TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection.  Journal of Immunology 186(4):2422-9. [PubMedID:21242525]

H-2Kb/SIINFEKL (Ovalbumin)

Jeras et al (2010) Induction/engineering, detection, selection, and expansion of clinical-grade human antigen-specific CD8 cytotoxic T cell clones for adoptive immunotherapy. Journal of Biomedicine and Biotechnology 2010:705215 [PubMed:20224660]

Joeckel et al (2011) Mouse granzyme K has pro-inflammatory potential. Cell Death Differentiation 18:1112 [PubMedID:21311565]

Jones et al (2009) Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. European Journal of Immunology 39:3195 [PubMedID:19658091]

Kandasamy et al (2011) Lactobacillus rhamnosus GG secreting an antigen and Interleukin-2 translocates across the gastrointestinal tract and induces an antigen specific immune response. Microbiology and Immunology 55:704 [PubMedID:21806675]

Kokolus et al (2013) Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature. PNAS [PubMedID:24248371]

H-2Ld/SPSYVYHQF

Kvistborg et al (2009) Fast generation of dendritic cells. Cellular Immunology 260:56 [PubMedID:19818956]

Lambeck et al (2010) Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens. Vaccine 28:4275 [PubMedID:20434555]

Lepone, L. et al. (2010). Monofunctional and Polyfunctional CD8+ T Cell Responses to Human Herpesvirus 8 Lytic and Latency Proteins. Clinical and Vaccine Immunolog 17 1507-1516. [PubMedID:20719985]

A*02:01/QMARLAWEA
A*02:01/LLNGWRWRL
A*02:01/LMWYELSKI
A*02:01/LVLILYLLCV
A*02:01/WATESPIYV

Lopes et al. (2011). A lentiviral vector pseudotype suitable for vaccine development. Journal of Gene Medicine. 13:181.[PubMedID: 21394858]

Luckashenak, N. et al. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells control CD8+ T cell tolerance in vivo. Immunity. 28: 521-532.[PubMedID: 18387832]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SSIEFARL (HSV-gpB)
H-2Kb/TSYKFESV (vaccinia virus B8R)

Martinuzzi et al. (2011) Accelerated co-cultured dendritic cells (acDCs) enhance human antigen-specific T-cell responses. Blood 118:2128 [PubMedID: 21715316]

Matrai et al. (2011). Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. Hepatology. 53:1696  [PubMedID: 21520180]

Matter, M. et al. (2006). Elimination of chronic viral infection by blocking CD27 signaling. J. Exp. Med. 203: 2145-2155. [PubMedID: 16923852]

Mazzarella, G. et al (2008). Gliadin activates HLA class-1-restricted CD8+ T cells in celiac disease intestinal mucosa and induces enterocyte apoptosis. Gastroenterology. 134: 1017-1027. [PubMedID: 18395083]

A*02:01/QLIPCMDVVL (Gliadin pA2)
A*02:01/SLYNTVATL (HIV-1 gag17)

Mbitikon-Kobo et al (2009) Characterization of a CD44/CD122int memory CD8 T cell subset generated under sterile inflammatory conditions. Journal of Immunology 182:3846 [PubMedID:19265164]

Möller et al (2008) Dendritic Cell Maturation With Poly(I:C)-based Versus PGE2-based Cytokine Combinations Results in Differential Functional Characteristics Relevant to Clinical Application. Journal of Immunotherapy 31:506 [PubMedID:18463533]

Negri et al (2010) Transduction of Human Antigen-Presenting Cells with Integrase-Defective Lentiviral Vector Enables Functional Expansion of Primed Antigen-Specific CD8+ T Cells. Human Gene Therapy 21:1029 [PubMedID:20210625]

Nishimoto et al (2011) Modification of human embryonic stem cell-derived dendritic cells with mRNA for efficient antigen presentation and enhanced potency. Regenerative Medicine 6:303 [PubMedID:21548736]

Omoto et al. (2010). Granzyme B is a novel interleukin-18 converting enzyme. Journal of Dermatological Science 59:129  [PubMedID:20621450]

H-2Kd/GYKDGNEYI (Listeriolysin O)
H-2Kd/RRLGRTLLL (Polyoma virus middle T protein)

Opitz et al (2011) Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis. PloS Pathogens 7:e1002233 [PubMedID:21909276]

Ortner et al (2011) The Adaptor Protein Bam32 in Human Dendritic Cells Participates in the Regulation of MHC Class I-Induced CD8+ T Cell Activation Journal of Immunology 187:3972 [PubMedID:21930970]

Pagni, PP (2014) Combination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model. Diabetes. 63(6). pp2015-25. [PubMedID: 24520125]

Panoskaltsis-Mortari, A. et al. (2008). In situ identification of allospecific B cells using pentamers. Blood 111: 3904-5. [PubMedID:18362221]

Perona-Wright et al. (2012). Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. PNAS epub. [PubMedID:23091017]

Sacquin et al (2012) Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected mice. Brain, Behavior, and Immunity [PubMedID:22522067]

Shimizu et al. (2010). HLA-B62 as a possible ligand for the human homologue of mouse macrophage MHC receptor 2 (MMR2) on monocytes. Gene 454:31. [PubMedID:20123006]

Smith et al (2012) Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells. Blood [PubMedID:22942184]

Soderquest et al. (2011). Cutting Edge: CD8+ T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses.  Journal of Immunology 186:3304  [PubMedID:21307295]

Sofra et al (2009) Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection. European Journal of Immunology 39:85 [PubMedID:19089809]

Stone et al (2011). Interaction of Streptavidin-Based Peptide–MHC Oligomers (Tetramers) with Cell-Surface TCRs Journal of Immunology epub [PubMedID:22102724]

Suchard (2012). Missing: A diagnostic technique to enumerate antigen-specific T cells. Crit. Rev. Oncol./Hematol. 83:276. [PubMedID:22137827]

Svensson, A. et al. (2005). Neurokinin 1 receptor signaling affects the local innate immune defense against genital Herpes virus infection. J. Immunol. 175: 6802-6811. [PubMedID:16272337]

H-2Kb/SSIEFARL (HSV-1 gp B)

Svensson, A. et al. (2005). Protective immunity to genital herpes simplex virus type 2 infection is mediated by T-bet. J. Immunol. 174: 6266-6273. [PubMedID:15879125]

H-2Kb/SSIEFARL (HSV-1 gp B)

Tellam et al. (2012). Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1. PLoS Path. 8:e1003112. [PubMedID:PMC3531512]

Rigato, P. et al. (2011). Heterologous plasmid DNA prime-recombinant human adenovirus 5 boost vaccination generates a stable pool of protective long-lived CD8+ T effector memory cells specific for a human parasie, Trypanosoma Cruzi.  Infection and Immunity. in press. [PubMedID:21357719]

Takamura, S. et al. (2010) Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+ T Cells by Rapid Induction of Multiple Inhibitory Receptors.  Journal of Immunology 184: 4696-4707 [PubMedID:20351188]

H-2Db/CCLCLTVFL (F-MuLV gag 75-83)

Tan et al. (2011). Retinoic Acid as a Vaccine Adjuvant Enhances CD8+ T Cell Response and Mucosal Protection from Viral Challenge. Journal of Virology. 85:8316. [PubMedID:21653670]

Tamminen et al (2012) A comparison of immunogenicity of norovirus GII-4 virus-like particles and P-particles. Immunology 135:89 [PubMedID:22044070]

Tashiro-Yamaji et al. (2012) Specific binding of HLA-B44 to human macrophage MHC receptor 1 on monocytes Gene [PubMedID:22525042]

Tashiro-Yamaji et al. (2006). Macrophage MHC receptor 2: A novel receptor on allograft (H-2DdKd)-induced macrophage (H-2DbKb) recognizing an MHC class I molecule, H-2Kd, in mice. Gene. 384:1 [PubMedID:17010536]

Tosello et al (2009) Differential expression of constitutive and inducible proteasome subunits in human monocyte-derived DC differentiated in the presence of IFN-α or IL-4.  European Journal of Immunology 39:56 [PubMedID:19065646]

Tosiek et al. (2011). CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation. Journal of Immunology 186:6106  [PubMedID:21518973]

Tseng et al (2009) Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells. Regenerative Medicine 4:513 [PubMedID:19580370]

Uto et al. (2011). Comparative activity of biodegradable nanoparticles with aluminum adjuvants: Antigen uptake by dendritic cells and induction of immune response in mice. Immunology Letters 140:36 [PubMedID:21693134]

Ventre et al (2012) Negative Regulation of NKG2D Expression by IL-4 in Memory CD8 T Cells. Journal of Immunology [PubMedID:22942430]

Verschelde, C. et al. (2006). Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection. Cell Death Differ. 13: 1213-1221. [PubMedID:16294210]

Vollers et al (2008) Class II major histocompatibility complex tetramer staining: progress, problems, and prospects. Immunology 123:305 [PubMedID:18251991]

Wickham, S. et al. (2005). Chemokine receptor deficiency is associated with increased chemokine expression in the peripheral and central nervous systems and increased resistance to herpetic encephalitis. J. NeuroImmunol. 162: 51-59. [PubMedID:15833359]

H-2Kb/SSIEFARL (HSV-1 gp B)

Yang, W. et al. (2007). Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML). Int. Immunol. 19: 1083-1093 [PubMedID:17660502]

Zelenay et al (2012) The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice Journal of Clinical Investigation [PubMedID:22505458]

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Model Antigen

Abdel-Motel, UM. et al. (2009). Mechanism for increased immunogenicity of vaccines that form in vivo immune complexes with the natural anti-Gal antibody. Vaccine. 27: 3072-3082. [PubMedID: 19428921]

H-2Kb/SIINFEKL (Ovalbumin)

Adriouch et al (2011) Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer. Frontiers In Microbiology 2:199 [PubMedID:22046170]

Amidi et al (2012) Induction of humoral and cellular immune responses by antigen-expressing immunostimulatory liposomes. Journal of Controlled Release [PubMedID:22940204]

Annoni, A. et al. (2009). In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance. Blood. 114: 5152-5161. [PubMedID: 19794140]

H-2Kd/HYLSTQSAL (eGFP)

Arnaboldi, PM. et al. (2009). Suppression of Th1 and Th17, but not Th2, responses in a CD8+ T cell-mediated model of oral tolerance. Mucosal Immunology. 2: 427-438. [PubMedID: 19571798]

H-2Kb/SIINFEKL (Ovalbumin)

Bahjat, K.S. et al. (2006). Cytosolic Entry Controls CD8 + T cell Potency During Bacterial Infection. Infect. Immun. 74: 6387-6397. [PubMedID: 16954391]

H-2Kb/SIINFEKL (Ovalbumin)

Bahjat, K. et al. (2009). Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria. PLos Pathogens. 5: e1000568 [PubMedID:19730694]

H-2Kb/SIINFEKL (Ovalbumin)

Binder, R.et al. (2005). Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells. Nature Immunol. 6: 593-599. [PubMedID: 15864309]

H-2Kb/SIINFEKL (Ovalbumin)

Black et al (2012) Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo. Advanced Materials 24:3845 [PubMedID:22550019]

Bouma, G. et al. (2007). Impaired T cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood. 110: 4278-84 [PubMedID:17673604]

H-2Kb/SIINFEKL (Ovalbumin)

Bourquin, C. et al. (2007). Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T cell and IgG2a response. Blood 109: 2953-2960. [PubMedID:17132722]

H-2Kb/SIINFEKL (Ovalbumin)

Brinkman et al (2004) Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity. Letters in Drug Design and Discovery 1:137

Chapman et al (2012) Platelets Present Antigen in the Context of MHC Class I. Journal of Immunology 189:916 [PubMedID:22706078]

Connolly, MK. et al. (2009). In liver fibrosis, dendritc cells govern hepatic inflammation in mice via TNF-a. J. Clin. Invest. 119: 3213-3225 [PubMedID:19855130]

H-2Kb/SIINFEKL (Ovalbumin)

Cuburu et al (2007) Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine 51:8598 [PubMedID:17996991]

Daniel, B. et al. (2010). A simple method to detect Toxoplasma Gondii-specific cytotoxic T cells in vivo. J. Imm. Methods, 355: 86-90 [PubMedID:20149795]

H-2Kb/SIINFEKL (Ovalbumin)

Diebold, SS. et al. (2008). Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines. Gene Therapy. 16: 359-366 [PubMedID: 19052633]

H-2Kb/SIINFEKL (Ovalbumin)

D'Orsogna et al (2012) Detection of allo-HLA cross-reactivity by virus-specific memory T-cell clones using single HLA-transfected K562 cells. Methods in Molecular Biology 882:339 [PubMedID:22665243]

Derbyshire et al (2011) Molecular mechanisms of induction of antigen-specific allograft tolerance by intranasal peptide administration. J. Immunol. 186:5719. [PubMedID:21490154]

Eby et al (2012) Polymer micelles with pyridyl disulfide-coupled antigen traffic through lymphatics and show enhanced cellular responses following immunization. Acta Biomaterialia [PubMedID:22698945]

Franck et al (2012) Immunological Tolerance to Muscle Autoantigens Involves Peripheral Deletion of Autoreactive CD8+ T Cells. PLoS One 7: e36444 [PubMedID:22570714]

Furmanski et al (2010) Peptide-Specific, TCR-α–Driven, Coreceptor-Independent Negative Selection in TCR α-Chain Transgenic Mice. J. Immunol. 184:650. [PubMedID:19995903]

Ga, M. et al. (2007). Single CX3CL1-Ig DNA administration enhances T cell priming in vivo. Vaccine 25: 4554-63. [PubMedID:[17493713]

H-2Kb/SIINFEKL (Ovalbumin)

Gerbitz et al (2012) Stromal Interferon-γ Signaling and Cross-Presentation Are Required to Eliminate Antigen-Loss Variants of B Cell Lymphomas in Mice.PLoS One 7:e34552 [PubMedID:22479645]

Goold, H. et al. (2011). Conventional Dendritic Cells Are Required for the Activation of Helper-Dependent CD8 T Cell Responses to a Model Antigen After Cutaneous Vaccination with Lentiviral Vectors. Journal of Immunology 186: 4565-72 [PubMedID: 21389256]

H-2Kb/SIINFEKL (Ovalbumin)

Gottrand et al (2012) Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice. Journal of Gene medicine [PubMedID:22228582]

Govers et al (2012) Magnetic-Activated Cell Sorting of TCR-engineered T cells using tCD34 as a gene marker, but not pMHC multimers, results in significant numbers of functional CD4 and CD8 T cells. Human Gene Therapy Methods [PubMedID:22746173]

Gutermuth, J. et al. (2009). Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V{alpha}2 down-regulation. J. Immunol. 183: 3130-3138. [PubMedID: 19675167]

H-2Kb/SIINFEKL (Ovalbumin)

Harms, JS. et al. (2009) Evaluation of recombinant invasive, non-pathogenic Eschericia coli as a vaccine vector against the intracellular pathogen, Brucella. Journal of Immune Based Therapies and Vaccines. 7: 1 [PubMedID: 19126207]

H-2Kd/HYLSTQSAL (eGFP)

Hamasaki, T. et al. (2010).  Modulation of Gene Expression Related to Toll-Like Receptor Signaling in Dendritic Cells by Poly(g-Glutamic Acid) Nanoparticles.  Clinical and Vaccine Immunology 17: 748-276 [PubMedID: 20219877]

H-2Kb/SIINFEKL (Ovalbumin)

Heffernan et al (2011) In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines. Biomaterials 32:926 [PubMedID:20965561]

Hegazy et al (2012) Evaluation of Salmonella enterica Type III Secretion System Effector Proteins as Carriers for Heterologous Vaccine Antigens Infection and Immunity 80:1193 [PubMedID:22252866]

Hinterleitner et al (2012) Adoptive Transfer of siRNA Cblb-Silenced CD8+ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model. PLoS One 7:e44295 [PubMedID:22962608]

Howland et al (2008) Inducing Efficient Cross-priming Using Antigen-coated Yeast Particles. Journal of Immunotherapy 31:607 [PubMedID:18600183]

Hubert, S. et al. (2010).  Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.  Journal of Experimental Medicine [PubMedID: 20975043]

H-2Kb/SIINFEKL (Ovalbumin)

Johansson et al (2012) Intradermal Electroporation of Naked Replicon RNA Elicits Strong Immune Responses. PLoS One 7:e29732 [PubMedID:22238645]

Joshi et al (2012) Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation Journal of Leukocyte Biology epub [PubMedID:22331103]

H-2Kb/SIINFEKL (Ovalbumin)

Khan et al (2011) Regulation of T Cell Priming by Lymphoid Stroma. PLoS One 6: e26138 [PubMedID:22110583]

Kuipers, H. et al. (2010) Dicer-Dependent MicroRNAs Control Maturation, Function, and Maintenance of Langerhans Cells In Vivo. J. Immunology. 185:400-409 . [PubMedID:20530258]

H-2Kb/SSIEFARL

Leggat, JA. et al. (2008). Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization. J. Allergy Clin. Immunol. 122: 1014-1021. [PubMedID:18804851]

H-2Kb/SIINFEKL (Ovalbumin)

Li et al. (2012). Dendritic cells sequester antigenic epitopes for prolonged periods in the absence of antigen-encoding genetic information. PNAS 109:17543. [PubMedID:23045695]

H-2Kb/SIINFEKL (Ovalbumin)

Luci, C. et al. (2006). Dendritic cell-mediated induction of mucosal cytotoxic responses following intravaginal immunization with the non-toxic B subunit of Cholera toxin. J. Immunol. 176: 2749-2757. [PubMedID:16493030]

H-2Kb/SIINFEKL (Ovalbumin)

Luckashenak, N. et al. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells control CD8+ T cell tolerance in vivo. Immunity. 28: 521-532. [PubMedID:18387832]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SSIEFARL (HSV-gpB)
H-2Kb/TSYKFESV (vaccinia virus B8R)

Lund et al (2012) VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics Cell Reports epub

Martin-Orozco, et al. (2006). Programmed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens. J. Immunol. 177: 8291-8295. [PubMedID:17142723]

H-2Kb/SIINFEKL (Ovalbumin)

Mascolo, D. et al. (2007). Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response. FEMS Immunol. Med. Microbiol. 50: 59-66. [PubMedID: 17391361]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SSYSYSSL

McBurney, WT. et al. (2008). In vivo activity of cationic immune stimulating complexes (PLUSCOMs). Vaccine. 26: 4549-4556 [PubMedID: 18585421]

H-2Kb/SIINFEKL (Ovalbumin)

McIlroy, D. et al. (2009). DNA/Amphiphilic block copolymer nanospheres promote low-dose DNA vaccination. Mol. Ther. 17: 1473-1481 [PubMedID: 19417740]

H-2Kb/SIINFEKL (Ovalbumin)

Moreau et al (2012) Absence of Galectin-1 accelerates CD8+ T cell-mediated graft rejection. European Journal of Immunology [PubMedID:22865279]

Mouries, J. et al. (2008). Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation. Blood. 112: 3713-3722 [PubMedID: 18698004]

H-2Kb/SIINFEKL (Ovalbumin)

Myschik et al (2008) Immunostimulatory biodegradable implants containing the adjuvant Quil-A—Part II: In vivo evaluation Journal of Drug Targeting 16:224 [PubMedID:18365884]

Myschik et al (2008) Immunogenicity of lipid sustained release implants containing imiquimod, α-galactosylceramide, or Quil-A . Die Pharmazie 63:686 [PubMedID:18819523]

Negri et al (2012) Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines. Retrovirology 9:69 [PubMedID:22913641]

Noble, A. et al. (2006). Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage. Blood 107: 4475-4483. [PubMedID:16467201]

H-2Kb/SIINFEKL (Ovalbumin)

Nordly et al (2011) Immunity by formulation design: Induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method. Journal of Controlled Release 150:307 [PubMedID:21111765]

Nordly, P. et al. (2010). Incorporation of the TLR4 Agonist Monophosphoryl Lipid A Into the Bilayer of DDA/TDB Liposomes: Physico-Chemical Characterization and Induction of CD8(+) T-Cell Responses In Vivo. Pharmaceutical Research [PubMedID:21042837]

H-2Kb/SIINFEKL (Ovalbumin)

Nouri-Shirazi et al (2012) Exposure to Nicotine Adversely Affects the Dendritic Cell System and Compromises Host Response to Vaccination Journal of Immunology 188:2359 [PubMedID:22279108]

Papatriantafyllou et al (2012) Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance. PNAS 109: 1631 [PubMedID:22307622]

Pascual, DW. et al. (2008). The absence of lymphoid CD8+ dendritic cell maturation in L-selectin-/- respiratory compartment attenuates antiviral immunity J Immunol. 181: 1345-1356 [PubMedID: 18606689]

H-2Kb/SIINFEKL (Ovalbumin)

Puaux, A-L et al. (2006) A very rapid and simple assay based on trogocytosis to detect and measure specific T and B cell reactivity by flow cytometry. Eur. J. Immunol. 36: 779-788. [PubMedID:16482513]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Db/KAVYNFATC (LCMV GP1)

Ren, Y. et al. (2006). OVA-specific CD8+ T cells do not express granzyme B during anterior chamber associated immune deviation. Graefes Arch. Clin. Exp. Ophthalmol. 244: 1315-1321. [PubMedID:16538449]

H-2Kb/SIINFEKL (Ovalbumin)

Reuter et al (2012) Foxp3 regulatory T cells control persistence of viral CNS infection.PLoS One 7:e33989 [PubMedID:22448284]

Rolf et al. (2012). AMPKα1: A glucose sensor that controls CD8 T-cell memory. Eur. J. Immunol. Epub. [PubMedID:23310952]

H-2Kb/SIINFEKL (Ovalbumin)

Rowe, HM. et al. (2009). Expression of vFLIP in a lentiviral vaccine vector activates NF-kB matures dendritic cells and increases CD8+ T-cell responses. J. Virol. 83: 1555-1562 [PubMedID: 19036811]

H-2Kb/SIINFEKL (Ovalbumin)

Sakamoto, N et al. (2011). Apolipoprotein B Binding Domatins: Evidence That They Are Cell-Penetrating Peptides That Efficiently Deliver Antigenic Peptide for Cross-Presentation of Cytotoxic T Cells. Journal of Immunology 186: 5004-5011. [PubMedID:21402897]

H-2Kb/SIINFEKL (Ovalbumin)

Saveanu, L. et al. (2009). IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science. 325: 213-217. [PubMedID:19498108]

H-2Kb/SIINFEKL (Ovalbumin)

Schwandt et al (2011) Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis EMBO Journal  [PubMedID:22036947]

Stano et al (2011) PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration. Vaccine 29:804 [PubMedID:21094269]

Terabe, M. et al. (2008). IL-15 expands unconventional CD8aa NK1.1+T cells but not Va14Ja18+ NKT cells. J Immunol. 180: 7276-7286. [PubMedID:18490727]

H-2Kb/SIINFEKL (Ovalbumin)

Thangavelu et al (2011) The role of co-inhibitory signals in spontaneous tolerance of weakly mismatched transplants Immunobiology 216:918 [PubMedID:21281982]

Thomas et al (2012) Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage. Journal of Immunology 189:2181 [PubMedID:22844119]

Thompson, JM. et al. (2008). Alphavirus replicon particlaes acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. Vaccine. 26: 4267-4275 [PubMedID:18585421]

H-2Kb/SIINFEKL (Ovalbumin)

Tomihara et al (2011) Aging-associated B7-DC(+) B cells enhance anti-tumor immunity via Th1 and Th17 induction. Aging Cell 11:128[PubMedID:22044484]

Tripp et al (2010) Conditioning of the Injection Site With CpG Enhances the Migration of Adoptively Transferred Dendritic Cells and Endogenous CD8+ T-cell Responses. Journal of Immunotherapy 33:115 [PubMedID:20145551]

Tripp, CH. et al. (2009). Glycolipids injected into the skin are presented to NKT cells in the draining lymph node independently of migratory skin dendritic cells. J. Immunol. 182: 7644-7654. [PubMedID:19494288]

H-2Kb/SIINFEKL (Ovalbumin)

Uto, T. et al. (2009). Improvement of adaptive immunity by antigen-carrying biodegradable nanoparticles. Biochem. Biophys. Res. Comm. 379:600-604 [PubMedID:19121627]

H-2Kb/SIINFEKL (Ovalbumin)

Warncke et al (2011). Control of the specificity of T cell-mediated anti-idiotype immunity by natural regulatory T cells. Cancer Immunol. Immunothera. 60:49. [PubMedID:20848095]

Wells, JW. et al (2008). Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J Immunol. 181: 3422-3431 [PubMedID:18714014]

H-2Kb/SIINFEKL (Ovalbumin)
H-2Kb/SVYDFFVWL (TRP-2)

Wells, JW. et al. (2009). Suppression of allergic airway inflammation and IgE responses by a class I restricted allergen peptide vaccine. Mucosal Immunology 2: 54-62 [PubMedID:19079334]

H-2Kb/SIINFEKL (Ovalbumin)

Yamasaki et al. (2012). Intravenous genetic mesothelin vaccine based on human adenovirus 40 inhibits growth and metastasis of pancreatic cancer. Int. J. Cancer epub. [PubMedID:23233329]

H-2Kb/SIINFEKL (Ovalbumin)

Zheng et al. (2012). Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo. JEM 209:2157-2163. [PubMedID:23129747]

H-2Kb/SIYRYYGL (Synthetic variant of VSV Nucleoprotein 498–505)

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