Customer Case Studies

Our case studies communicate customers' successes with ProImmune's products applied to areas such as epitope discovery, vaccine research, co-staining of Pentamers and intracellular cytokines and antigen-specific cell separation with magnetic beads.

T Cell epitope discovery and immune monitoring

Epitope discovery in prostate cancer: the use of a custom Pentamer in the characterization of an immunodominant CTL epitope of PSA in mice; read case study.

REVEAL & ProVE® rapid epitope discovery system used to identify novel T cell epitopes in HIV-1; read case study.

Class II REVEAL binding assay helps characterize peptides in Grave's disease; read case study.

Identification of new epitopes in type 1 diabetes; read case study.

Novel epitope detection in phase II trial for colorectal cancer; read case study.

Pentamers identify allo-restricted T cells in study to advance research into cancer immunotherapy; read case study.

REVEAL and ProVE® used to identify first HTLV-2 MHC class I epitope; read case study.

Discovery of first VZV HLA-A2 epitope, using REVEAL & ProVE® technology; read case study.

REVEAL™ Rate assays and Pro5® Pentamers central to study investigating oxidative stress; read case study.

B Cell epitope discovery

Correlation between ProImmune’s B cell epitope prediction service and published epitopes for Human Papillomavirus (HPV) type 16 major late capsid protein L1; read case study.

ELISPOT Assay Cellular Analysis Service

First ever tumor-specific response observed for human patients in oncolytic adenovirus cancer gene therapy study; read case study.

Co-staining of Pentamers with intracellular cytokines

Pro5® MHC Class I Pentamer combined with intracellular cytokine staining shows how protein translation affects the molecular dynamics of antigen presentation; read case study.

Study using HIV-specific Pro5® MHC Class I Pentamers combined with intracellular cytokine staining provides useful data for the development of T cell vaccines; read case study.

Enrichment of antigen-specific T cells using Pentamers and magnetic beads

Pro5® MHC Class I Pentamers used to separate HBV-specific T cells for subsequent phenotypic analysis; read case study.

Pro5® Pentamers central in life-saving procedure for PTLD treatment; read case study.

Tissue Staining with Pro5^® MHC Class I Pentamers

In Situ Identification of Allospecific B Cells using Pentamers; read case study.

Pentamers used in vaccine development

CDC study on H5N1 vaccine uses Pro5® Pentamer to correlate immune response with protection; read case study.

Pro5® MHC Class I Pentamers used to evaluate vaccine safety; read case study.

New adjuvant drives unprecedented cytotoxic T cell response providing a potent vaccine development platform; read case study.

Pro5® Pentamers integral in successful research into novel immunization strategy; read case study.

Pro5® Pentamer central to Hepatitis B vaccine research; read case study.

NKT cell detection with CD1d tetramer

Insight gained into the significance of isoglobotrihexosylceramide (iGb3) ligand in mice using CD1d tetramer; read case study.

Use of CD1d tetramer contributes to evidence that NKT cells are important in the acquired immune response during helminthiasis; read case study.

CD1d Tetramer helps understand differentiation pathways of iNKT cells; read case study.

ProImmune’s Human CD1d tetramer detects NKT cells from non-human primates; read case study.

Research using PEPscreen^®: Custom Peptide Libraries

University of Manitoba researchers use PEPscreen® library for epitope mapping; read case study

Research into Type I Diabetes therapy makes use of PEPscreen® technology; read case study

HIV vaccine study in pigs uses PEPscreen® peptides in ELISPOT assays; read case study

PEPscreen® used in vaccine development for Mycobacterium tuberculosis; read case study